Five new secondary metabolites from an endophytic fungus Phomopsis sp. SZSJ-7B
Two previously undescribed lactones, phomolides A and B (1 and 2), and three new sesquiterpenoids, phomenes A–C (3–5), together with one known compound, colletotricholide A (6), were isolated from the endophytic fungus Phomopsis sp. SZSJ-7B. Their chemical structures, including the absolute configur...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Plant Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpls.2022.1049015/full |
| _version_ | 1797988643992764416 |
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| author | Yan Chen Yan Chen Yan Chen Huan Wang Xin Ke Xin Ke Xin Ke Zihuan Sang Zihuan Sang Zihuan Sang Min Kuang Min Kuang Weiwei Peng Weiwei Peng Weiwei Peng Jianbing Tan Jianbing Tan Yuting Zheng Yuting Zheng Zhenxing Zou Zhenxing Zou Haibo Tan Haibo Tan Haibo Tan |
| author_facet | Yan Chen Yan Chen Yan Chen Huan Wang Xin Ke Xin Ke Xin Ke Zihuan Sang Zihuan Sang Zihuan Sang Min Kuang Min Kuang Weiwei Peng Weiwei Peng Weiwei Peng Jianbing Tan Jianbing Tan Yuting Zheng Yuting Zheng Zhenxing Zou Zhenxing Zou Haibo Tan Haibo Tan Haibo Tan |
| author_sort | Yan Chen |
| collection | DOAJ |
| description | Two previously undescribed lactones, phomolides A and B (1 and 2), and three new sesquiterpenoids, phomenes A–C (3–5), together with one known compound, colletotricholide A (6), were isolated from the endophytic fungus Phomopsis sp. SZSJ-7B. Their chemical structures, including the absolute configurations, were comprehensively established by extensive analyses of NMR, high-resolution electrospray ionization mass spectrometry, electronic circular dichroism powered by theoretical calculations, and X-ray diffractions. Moreover, the cytotoxic and antibacterial activities of compounds 1–6 were also evaluated, and the results demonstrated that compound 2 showed significant antibacterial effects towards methicillin-resistant Staphylococcus aureus and S. aureus strains with minimum inhibitory concentration as low as 6.25 μg/ml, which was comparable to that of the clinical drug vancomycin. Moreover, all compounds showed no cytotoxic activity. |
| first_indexed | 2024-04-11T08:07:29Z |
| format | Article |
| id | doaj.art-da3d196769eb478cbc08f240bcbbca9c |
| institution | Directory Open Access Journal |
| issn | 1664-462X |
| language | English |
| last_indexed | 2024-04-11T08:07:29Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Plant Science |
| spelling | doaj.art-da3d196769eb478cbc08f240bcbbca9c2022-12-22T04:35:30ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2022-11-011310.3389/fpls.2022.10490151049015Five new secondary metabolites from an endophytic fungus Phomopsis sp. SZSJ-7BYan Chen0Yan Chen1Yan Chen2Huan Wang3Xin Ke4Xin Ke5Xin Ke6Zihuan Sang7Zihuan Sang8Zihuan Sang9Min Kuang10Min Kuang11Weiwei Peng12Weiwei Peng13Weiwei Peng14Jianbing Tan15Jianbing Tan16Yuting Zheng17Yuting Zheng18Zhenxing Zou19Zhenxing Zou20Haibo Tan21Haibo Tan22Haibo Tan23Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, ChinaHunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, ChinaKey Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, ChinaKey Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, ChinaXiangya School of Pharmaceutical Sciences, Central South University, Changsha, ChinaHunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, ChinaKey Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, ChinaXiangya School of Pharmaceutical Sciences, Central South University, Changsha, ChinaHunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, ChinaKey Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, ChinaXiangya School of Pharmaceutical Sciences, Central South University, Changsha, ChinaHunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, ChinaXiangya School of Pharmaceutical Sciences, Central South University, Changsha, ChinaHunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, ChinaKey Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, ChinaXiangya School of Pharmaceutical Sciences, Central South University, Changsha, ChinaHunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, ChinaXiangya School of Pharmaceutical Sciences, Central South University, Changsha, ChinaHunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, ChinaXiangya School of Pharmaceutical Sciences, Central South University, Changsha, ChinaHunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, ChinaXiangya School of Pharmaceutical Sciences, Central South University, Changsha, ChinaHunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, ChinaKey Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, ChinaTwo previously undescribed lactones, phomolides A and B (1 and 2), and three new sesquiterpenoids, phomenes A–C (3–5), together with one known compound, colletotricholide A (6), were isolated from the endophytic fungus Phomopsis sp. SZSJ-7B. Their chemical structures, including the absolute configurations, were comprehensively established by extensive analyses of NMR, high-resolution electrospray ionization mass spectrometry, electronic circular dichroism powered by theoretical calculations, and X-ray diffractions. Moreover, the cytotoxic and antibacterial activities of compounds 1–6 were also evaluated, and the results demonstrated that compound 2 showed significant antibacterial effects towards methicillin-resistant Staphylococcus aureus and S. aureus strains with minimum inhibitory concentration as low as 6.25 μg/ml, which was comparable to that of the clinical drug vancomycin. Moreover, all compounds showed no cytotoxic activity.https://www.frontiersin.org/articles/10.3389/fpls.2022.1049015/fullendophytic fungusPhomopsissecondary metabolitesantibacterial activitycytotoxic activity |
| spellingShingle | Yan Chen Yan Chen Yan Chen Huan Wang Xin Ke Xin Ke Xin Ke Zihuan Sang Zihuan Sang Zihuan Sang Min Kuang Min Kuang Weiwei Peng Weiwei Peng Weiwei Peng Jianbing Tan Jianbing Tan Yuting Zheng Yuting Zheng Zhenxing Zou Zhenxing Zou Haibo Tan Haibo Tan Haibo Tan Five new secondary metabolites from an endophytic fungus Phomopsis sp. SZSJ-7B Frontiers in Plant Science endophytic fungus Phomopsis secondary metabolites antibacterial activity cytotoxic activity |
| title | Five new secondary metabolites from an endophytic fungus Phomopsis sp. SZSJ-7B |
| title_full | Five new secondary metabolites from an endophytic fungus Phomopsis sp. SZSJ-7B |
| title_fullStr | Five new secondary metabolites from an endophytic fungus Phomopsis sp. SZSJ-7B |
| title_full_unstemmed | Five new secondary metabolites from an endophytic fungus Phomopsis sp. SZSJ-7B |
| title_short | Five new secondary metabolites from an endophytic fungus Phomopsis sp. SZSJ-7B |
| title_sort | five new secondary metabolites from an endophytic fungus phomopsis sp szsj 7b |
| topic | endophytic fungus Phomopsis secondary metabolites antibacterial activity cytotoxic activity |
| url | https://www.frontiersin.org/articles/10.3389/fpls.2022.1049015/full |
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