Fibromyalgia and mortality: a systematic review and meta-analysis
Objective To conduct a systematic review of the literature on the association between fibromyalgia and mortality and to pool the results in a meta-analysis.Methods The authors searched the PubMed, Scopus, and Web of Science databases using the key words ‘fibromyalgia’ and ‘mortality’ to identify stu...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2023-07-01
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| Series: | RMD Open |
| Online Access: | https://rmdopen.bmj.com/content/9/3/e003005.full |
| _version_ | 1797640094115430400 |
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| author | Roni Peleg Yulia Treister-Goltzman |
| author_facet | Roni Peleg Yulia Treister-Goltzman |
| author_sort | Roni Peleg |
| collection | DOAJ |
| description | Objective To conduct a systematic review of the literature on the association between fibromyalgia and mortality and to pool the results in a meta-analysis.Methods The authors searched the PubMed, Scopus, and Web of Science databases using the key words ‘fibromyalgia’ and ‘mortality’ to identify studies that addressed an association between fibromyalgia and mortality. Original papers that assessed associations between fibromyalgia and mortality (all or specific causes) and provided an effect measure (hazard ratio (HR), standardised mortality ratio (SMR), odds ratio (OR)) quantifying the relationship between fibromyalgia and mortality were included in the systematic review. Of 557 papers that were initially identified using the search words, 8 papers were considered eligible for the systematic review and meta-analysis. We used a Newcastle-Ottawa scale to assess the risk of bias in the studies.Results The total fibromyalgia group included 188 751 patients. An increased HR was found for all-cause mortality (HR 1.27, 95% CI 1.04 to 1.51), but not for the subgroup diagnosed by the 1990 criteria. There was a borderline increased SMR for accidents (SMR 1.95, 95% CI 0.97 to 3.92), an increased risk for mortality from infections (SMR 1.66, 95% CI 1.15 to 2.38), and suicide (SMR 3.37, 95% CI 1.52 to 7.50), and a decreased mortality rate for cancer (SMR 0.82, 95% CI 0.69 to 0.97). The studies showed significant heterogeneity.Conclusions These potential associations indicate that fibromyalgia should be taken seriously, with a special focus on screening for suicidal ideation, accident prevention, and the prevention and treatment of infections. |
| first_indexed | 2024-03-11T13:26:53Z |
| format | Article |
| id | doaj.art-da3daca700574788888be62e89d2d92b |
| institution | Directory Open Access Journal |
| issn | 2056-5933 |
| language | English |
| last_indexed | 2024-03-11T13:26:53Z |
| publishDate | 2023-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | RMD Open |
| spelling | doaj.art-da3daca700574788888be62e89d2d92b2023-11-03T06:25:07ZengBMJ Publishing GroupRMD Open2056-59332023-07-019310.1136/rmdopen-2023-003005Fibromyalgia and mortality: a systematic review and meta-analysisRoni Peleg0Yulia Treister-Goltzman11 Department of Family Medicine and Siaal Research Center for Family Practice and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel1 Department of Family Medicine and Siaal Research Center for Family Practice and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, IsraelObjective To conduct a systematic review of the literature on the association between fibromyalgia and mortality and to pool the results in a meta-analysis.Methods The authors searched the PubMed, Scopus, and Web of Science databases using the key words ‘fibromyalgia’ and ‘mortality’ to identify studies that addressed an association between fibromyalgia and mortality. Original papers that assessed associations between fibromyalgia and mortality (all or specific causes) and provided an effect measure (hazard ratio (HR), standardised mortality ratio (SMR), odds ratio (OR)) quantifying the relationship between fibromyalgia and mortality were included in the systematic review. Of 557 papers that were initially identified using the search words, 8 papers were considered eligible for the systematic review and meta-analysis. We used a Newcastle-Ottawa scale to assess the risk of bias in the studies.Results The total fibromyalgia group included 188 751 patients. An increased HR was found for all-cause mortality (HR 1.27, 95% CI 1.04 to 1.51), but not for the subgroup diagnosed by the 1990 criteria. There was a borderline increased SMR for accidents (SMR 1.95, 95% CI 0.97 to 3.92), an increased risk for mortality from infections (SMR 1.66, 95% CI 1.15 to 2.38), and suicide (SMR 3.37, 95% CI 1.52 to 7.50), and a decreased mortality rate for cancer (SMR 0.82, 95% CI 0.69 to 0.97). The studies showed significant heterogeneity.Conclusions These potential associations indicate that fibromyalgia should be taken seriously, with a special focus on screening for suicidal ideation, accident prevention, and the prevention and treatment of infections.https://rmdopen.bmj.com/content/9/3/e003005.full |
| spellingShingle | Roni Peleg Yulia Treister-Goltzman Fibromyalgia and mortality: a systematic review and meta-analysis RMD Open |
| title | Fibromyalgia and mortality: a systematic review and meta-analysis |
| title_full | Fibromyalgia and mortality: a systematic review and meta-analysis |
| title_fullStr | Fibromyalgia and mortality: a systematic review and meta-analysis |
| title_full_unstemmed | Fibromyalgia and mortality: a systematic review and meta-analysis |
| title_short | Fibromyalgia and mortality: a systematic review and meta-analysis |
| title_sort | fibromyalgia and mortality a systematic review and meta analysis |
| url | https://rmdopen.bmj.com/content/9/3/e003005.full |
| work_keys_str_mv | AT ronipeleg fibromyalgiaandmortalityasystematicreviewandmetaanalysis AT yuliatreistergoltzman fibromyalgiaandmortalityasystematicreviewandmetaanalysis |