Single alcohol exposure in early life damages hippocampal stem/progenitor cells and reduces adult neurogenesis
Alcohol exposure during pregnancy may cause fetal alcohol syndrome (FAS), characterized by impaired cognitive functions. Neurogenesis occurs in the adult hippocampus and is functionally associated with learning, memory, and mood disorders. However, whether early postnatal exposure to alcohol impairs...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2007-06-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996107000484 |
| _version_ | 1819161139848675328 |
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| author | Alessandro Ieraci Daniel G. Herrera |
| author_facet | Alessandro Ieraci Daniel G. Herrera |
| author_sort | Alessandro Ieraci |
| collection | DOAJ |
| description | Alcohol exposure during pregnancy may cause fetal alcohol syndrome (FAS), characterized by impaired cognitive functions. Neurogenesis occurs in the adult hippocampus and is functionally associated with learning, memory, and mood disorders. However, whether early postnatal exposure to alcohol impairs neurogenesis and through which mechanisms it occurs is poorly understood. Here, we report that a single episode of alcohol exposure in postnatal day 7 (P7) decreases neurogenesis in the adult hippocampus. Furthermore, we demonstrate a co-localization of glial fibrillar acidic protein, nestin, and vimentin with activated caspase-3 12 h after ethanol treatment. Finally, we show that the number of primary neurospheres derived from the hippocampi of alcohol-exposed mice is reduced compared to controls. These findings suggest that alcohol exposure in postnatal mice reduces the pool of neural stem/progenitor cells in the DG, and subsequently results in a decrease of adult neurogenesis. This may explain certain aspects of impaired hippocampal functions in FAS. |
| first_indexed | 2024-12-22T17:07:36Z |
| format | Article |
| id | doaj.art-da3fa8452c714c83ae997f258d5beb13 |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-22T17:07:36Z |
| publishDate | 2007-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-da3fa8452c714c83ae997f258d5beb132022-12-21T18:19:10ZengElsevierNeurobiology of Disease1095-953X2007-06-01263597605Single alcohol exposure in early life damages hippocampal stem/progenitor cells and reduces adult neurogenesisAlessandro Ieraci0Daniel G. Herrera1Department of Psychiatry, Weill Medical College of Cornell University, 1300 York Avenue, Box 244, New York, NY 10021, USACorresponding author. Fax: +1 212 746 8529.; Department of Psychiatry, Weill Medical College of Cornell University, 1300 York Avenue, Box 244, New York, NY 10021, USAAlcohol exposure during pregnancy may cause fetal alcohol syndrome (FAS), characterized by impaired cognitive functions. Neurogenesis occurs in the adult hippocampus and is functionally associated with learning, memory, and mood disorders. However, whether early postnatal exposure to alcohol impairs neurogenesis and through which mechanisms it occurs is poorly understood. Here, we report that a single episode of alcohol exposure in postnatal day 7 (P7) decreases neurogenesis in the adult hippocampus. Furthermore, we demonstrate a co-localization of glial fibrillar acidic protein, nestin, and vimentin with activated caspase-3 12 h after ethanol treatment. Finally, we show that the number of primary neurospheres derived from the hippocampi of alcohol-exposed mice is reduced compared to controls. These findings suggest that alcohol exposure in postnatal mice reduces the pool of neural stem/progenitor cells in the DG, and subsequently results in a decrease of adult neurogenesis. This may explain certain aspects of impaired hippocampal functions in FAS.http://www.sciencedirect.com/science/article/pii/S0969996107000484ApoptosisEthanolDentate gyrusHippocampusNeurogenesisStem/Progenitor cells |
| spellingShingle | Alessandro Ieraci Daniel G. Herrera Single alcohol exposure in early life damages hippocampal stem/progenitor cells and reduces adult neurogenesis Neurobiology of Disease Apoptosis Ethanol Dentate gyrus Hippocampus Neurogenesis Stem/Progenitor cells |
| title | Single alcohol exposure in early life damages hippocampal stem/progenitor cells and reduces adult neurogenesis |
| title_full | Single alcohol exposure in early life damages hippocampal stem/progenitor cells and reduces adult neurogenesis |
| title_fullStr | Single alcohol exposure in early life damages hippocampal stem/progenitor cells and reduces adult neurogenesis |
| title_full_unstemmed | Single alcohol exposure in early life damages hippocampal stem/progenitor cells and reduces adult neurogenesis |
| title_short | Single alcohol exposure in early life damages hippocampal stem/progenitor cells and reduces adult neurogenesis |
| title_sort | single alcohol exposure in early life damages hippocampal stem progenitor cells and reduces adult neurogenesis |
| topic | Apoptosis Ethanol Dentate gyrus Hippocampus Neurogenesis Stem/Progenitor cells |
| url | http://www.sciencedirect.com/science/article/pii/S0969996107000484 |
| work_keys_str_mv | AT alessandroieraci singlealcoholexposureinearlylifedamageshippocampalstemprogenitorcellsandreducesadultneurogenesis AT danielgherrera singlealcoholexposureinearlylifedamageshippocampalstemprogenitorcellsandreducesadultneurogenesis |