Tau in cerebrospinal fluid induces neuronal hyperexcitability and alters hippocampal theta oscillations

Tau in cerebrospinal fluid induces neuronal hyperexcitability and alters hippocampal theta oscillations

Abstract Alzheimer’s disease (AD) and other tauopathies are characterized by the aggregation of tau into soluble and insoluble forms (including tangles and neuropil threads). In humans, a fraction of both phosphorylated and non-phosphorylated N-terminal to mid-domain tau species, are secreted into c...

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Bibliographic Details
Main Authors: Jessica Brown, Elena Camporesi, Juan Lantero-Rodriguez, Maria Olsson, Alice Wang, Blanca Medem, Henrik Zetterberg, Kaj Blennow, Thomas K. Karikari, Mark Wall, Emily Hill
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Acta Neuropathologica Communications
Subjects:
Tau
Electrophysiology
Cerebrospinal fluid
Tauopathy
Theta oscillations
Online Access:https://doi.org/10.1186/s40478-023-01562-5

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