A decreased number of circulating regulatory T cells is associated with adverse pregnancy outcomes in patients with systemic lupus erythematosus
Abstract Objective As an autoimmune disease affecting women of reproductive age, systemic lupus erythematosus (SLE) is linked to adverse fetal and maternal outcomes. However, the status of peripheral lymphocytes in SLE patients with different pregnancy outcomes is unclear. This retrospective cross‐s...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-12-01
|
| Series: | Immunity, Inflammation and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/iid3.731 |
| _version_ | 1797987086814412800 |
|---|---|
| author | He‐Tong Li Sheng‐Xiao Zhang Jia‐Qi Zhang Ting Cheng Yan Liu Hong‐Qi Liu Min Hao Jun‐Wei Chen |
| author_facet | He‐Tong Li Sheng‐Xiao Zhang Jia‐Qi Zhang Ting Cheng Yan Liu Hong‐Qi Liu Min Hao Jun‐Wei Chen |
| author_sort | He‐Tong Li |
| collection | DOAJ |
| description | Abstract Objective As an autoimmune disease affecting women of reproductive age, systemic lupus erythematosus (SLE) is linked to adverse fetal and maternal outcomes. However, the status of peripheral lymphocytes in SLE patients with different pregnancy outcomes is unclear. This retrospective cross‐sectional study explored the relationship between lymphocyte subpopulations and pregnancy outcomes in married SLE female patients. Methods The absolute numbers of peripheral T, helper T (Th)1, Th2, Th17, regulatory T (Treg), B, and natural killer (NK) cell subpopulations from 585 female SLE patients and 91 female healthy controls (HCs) were assessed. We compared the lymphocyte subpopulations in SLE patients with HCs and analyzed the absolute number and ratio of Treg cells according to pregnancy outcome in SLE patients. Results SLE patients had decreased numbers of T, B, NK, Th1, Th2, Th17, and Treg cells and an imbalance in pro‐ and anti‐inflammatory cells (p < .05), as well as adverse pregnancy outcomes. In abortion patients, the number of Treg cells (p = .008) decreased, leading to an imbalance in effector T and Treg cells. The ratio of Treg cells was higher in SLE patients with nulliparity than in those with one or two parities. Conclusions The absolute numbers of lymphocyte subpopulations in SLE patients decreased, which was associated with abortion and parity (p < .05). These results suggest that a loss of immune tolerance mediated by Tregs triggers pregnancy loss. |
| first_indexed | 2024-04-11T07:43:25Z |
| format | Article |
| id | doaj.art-da42a0e0049043c7b07c3e8605aa8592 |
| institution | Directory Open Access Journal |
| issn | 2050-4527 |
| language | English |
| last_indexed | 2024-04-11T07:43:25Z |
| publishDate | 2022-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj.art-da42a0e0049043c7b07c3e8605aa85922022-12-22T04:36:25ZengWileyImmunity, Inflammation and Disease2050-45272022-12-011012n/an/a10.1002/iid3.731A decreased number of circulating regulatory T cells is associated with adverse pregnancy outcomes in patients with systemic lupus erythematosusHe‐Tong Li0Sheng‐Xiao Zhang1Jia‐Qi Zhang2Ting Cheng3Yan Liu4Hong‐Qi Liu5Min Hao6Jun‐Wei Chen7Department of Obstetrics and Gynecology Second Hospital of Shanxi Medical University Taiyuan ChinaKey Laboratory of Cellular Physiology, Ministry of Education Shanxi Medical University Taiyuan ChinaKey Laboratory of Cellular Physiology, Ministry of Education Shanxi Medical University Taiyuan ChinaKey Laboratory of Cellular Physiology, Ministry of Education Shanxi Medical University Taiyuan ChinaDepartment of Information management Second Hospital of Shanxi Medical University Taiyuan ChinaDepartment of Information management Second Hospital of Shanxi Medical University Taiyuan ChinaDepartment of Obstetrics and Gynecology Second Hospital of Shanxi Medical University Taiyuan ChinaKey Laboratory of Cellular Physiology, Ministry of Education Shanxi Medical University Taiyuan ChinaAbstract Objective As an autoimmune disease affecting women of reproductive age, systemic lupus erythematosus (SLE) is linked to adverse fetal and maternal outcomes. However, the status of peripheral lymphocytes in SLE patients with different pregnancy outcomes is unclear. This retrospective cross‐sectional study explored the relationship between lymphocyte subpopulations and pregnancy outcomes in married SLE female patients. Methods The absolute numbers of peripheral T, helper T (Th)1, Th2, Th17, regulatory T (Treg), B, and natural killer (NK) cell subpopulations from 585 female SLE patients and 91 female healthy controls (HCs) were assessed. We compared the lymphocyte subpopulations in SLE patients with HCs and analyzed the absolute number and ratio of Treg cells according to pregnancy outcome in SLE patients. Results SLE patients had decreased numbers of T, B, NK, Th1, Th2, Th17, and Treg cells and an imbalance in pro‐ and anti‐inflammatory cells (p < .05), as well as adverse pregnancy outcomes. In abortion patients, the number of Treg cells (p = .008) decreased, leading to an imbalance in effector T and Treg cells. The ratio of Treg cells was higher in SLE patients with nulliparity than in those with one or two parities. Conclusions The absolute numbers of lymphocyte subpopulations in SLE patients decreased, which was associated with abortion and parity (p < .05). These results suggest that a loss of immune tolerance mediated by Tregs triggers pregnancy loss.https://doi.org/10.1002/iid3.731abortionlupuslymphocyte subpopulationspregnancyTreg cells |
| spellingShingle | He‐Tong Li Sheng‐Xiao Zhang Jia‐Qi Zhang Ting Cheng Yan Liu Hong‐Qi Liu Min Hao Jun‐Wei Chen A decreased number of circulating regulatory T cells is associated with adverse pregnancy outcomes in patients with systemic lupus erythematosus Immunity, Inflammation and Disease abortion lupus lymphocyte subpopulations pregnancy Treg cells |
| title | A decreased number of circulating regulatory T cells is associated with adverse pregnancy outcomes in patients with systemic lupus erythematosus |
| title_full | A decreased number of circulating regulatory T cells is associated with adverse pregnancy outcomes in patients with systemic lupus erythematosus |
| title_fullStr | A decreased number of circulating regulatory T cells is associated with adverse pregnancy outcomes in patients with systemic lupus erythematosus |
| title_full_unstemmed | A decreased number of circulating regulatory T cells is associated with adverse pregnancy outcomes in patients with systemic lupus erythematosus |
| title_short | A decreased number of circulating regulatory T cells is associated with adverse pregnancy outcomes in patients with systemic lupus erythematosus |
| title_sort | decreased number of circulating regulatory t cells is associated with adverse pregnancy outcomes in patients with systemic lupus erythematosus |
| topic | abortion lupus lymphocyte subpopulations pregnancy Treg cells |
| url | https://doi.org/10.1002/iid3.731 |
| work_keys_str_mv | AT hetongli adecreasednumberofcirculatingregulatorytcellsisassociatedwithadversepregnancyoutcomesinpatientswithsystemiclupuserythematosus AT shengxiaozhang adecreasednumberofcirculatingregulatorytcellsisassociatedwithadversepregnancyoutcomesinpatientswithsystemiclupuserythematosus AT jiaqizhang adecreasednumberofcirculatingregulatorytcellsisassociatedwithadversepregnancyoutcomesinpatientswithsystemiclupuserythematosus AT tingcheng adecreasednumberofcirculatingregulatorytcellsisassociatedwithadversepregnancyoutcomesinpatientswithsystemiclupuserythematosus AT yanliu adecreasednumberofcirculatingregulatorytcellsisassociatedwithadversepregnancyoutcomesinpatientswithsystemiclupuserythematosus AT hongqiliu adecreasednumberofcirculatingregulatorytcellsisassociatedwithadversepregnancyoutcomesinpatientswithsystemiclupuserythematosus AT minhao adecreasednumberofcirculatingregulatorytcellsisassociatedwithadversepregnancyoutcomesinpatientswithsystemiclupuserythematosus AT junweichen adecreasednumberofcirculatingregulatorytcellsisassociatedwithadversepregnancyoutcomesinpatientswithsystemiclupuserythematosus AT hetongli decreasednumberofcirculatingregulatorytcellsisassociatedwithadversepregnancyoutcomesinpatientswithsystemiclupuserythematosus AT shengxiaozhang decreasednumberofcirculatingregulatorytcellsisassociatedwithadversepregnancyoutcomesinpatientswithsystemiclupuserythematosus AT jiaqizhang decreasednumberofcirculatingregulatorytcellsisassociatedwithadversepregnancyoutcomesinpatientswithsystemiclupuserythematosus AT tingcheng decreasednumberofcirculatingregulatorytcellsisassociatedwithadversepregnancyoutcomesinpatientswithsystemiclupuserythematosus AT yanliu decreasednumberofcirculatingregulatorytcellsisassociatedwithadversepregnancyoutcomesinpatientswithsystemiclupuserythematosus AT hongqiliu decreasednumberofcirculatingregulatorytcellsisassociatedwithadversepregnancyoutcomesinpatientswithsystemiclupuserythematosus AT minhao decreasednumberofcirculatingregulatorytcellsisassociatedwithadversepregnancyoutcomesinpatientswithsystemiclupuserythematosus AT junweichen decreasednumberofcirculatingregulatorytcellsisassociatedwithadversepregnancyoutcomesinpatientswithsystemiclupuserythematosus |