Surgical Outcomes and Prognostic Factors of Myxoid Liposarcoma in Extremities: A Retrospective Study
Objectives To evaluate treatments and prognostic factors for the myxoid liposarcoma in extremities. Methods We retrospectively reviewed 34 patients histologically diagnosed with myxoid liposarcoma arising in the extremities, treated in our hospital from 2010 to 2017. We recorded tumor locations, max...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-12-01
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| Series: | Orthopaedic Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/os.12566 |
| _version_ | 1818609117256744960 |
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| author | Kai Zheng Xiu‐chun Yu Ming Xu Yang Yang |
| author_facet | Kai Zheng Xiu‐chun Yu Ming Xu Yang Yang |
| author_sort | Kai Zheng |
| collection | DOAJ |
| description | Objectives To evaluate treatments and prognostic factors for the myxoid liposarcoma in extremities. Methods We retrospectively reviewed 34 patients histologically diagnosed with myxoid liposarcoma arising in the extremities, treated in our hospital from 2010 to 2017. We recorded tumor locations, max diameter, operations, complications, radiation, chemotherapy, survival, recrudescence, and metastases. Overall survival, treatments, and prognostic factors were subsequently analyzed. Results The mean age of 34 patients with myxoid liposarcoma in extremities was 49.1 years, and the mean follow‐up period was 65.1 months. The median survival time was 190 months. Five of 14 patients accepted recrudescence resection and two patients of 20 patients who underwent primary tumor resection or unplanned operation died of tumor progression. Although no statistical difference was found (X 2 = 3.331, P = 0.068), the lower mortality was confirmed in the patients who accepted primary tumor resection or unplanned operation. Eleven patients with a tumor diameter of 8.6 ± 4.7 cm accepted wide resection, while 23 patients with 17.2 ± 8.8 cm tumors accepted marginal resection. Statistical difference was found between the size of tumors with relatively wide resection and those with relatively marginal resection (F = 9.130, P = 0.005). No recurrence or metastasis occurred in patients who accepted wide resection, while 14 patients presented with local recurrence and 8 patients developed distant metastases among the 23 patients with marginal resection. Seven patients died of metastases, while one patient lived with metastases. No significant difference in survival was found between different surgical methods (X 2 = 0.9460, P = 0.3307). The average diameter of eight patients with distant metastases was 21.7 cm, which was considerable larger than the 12.1 cm of patients without metastasis. This difference was proven significant upon the statistical analysis (F = 9.412, P = 0.004). Conclusions Wide resection achieved good local control but was not unambiguously superior in long‐term survival. Myxoid liposarcoma tumors with larger diameters were more difficult to be submitted to wide resection and were more likely to present with distant metastasis. |
| first_indexed | 2024-12-16T14:53:26Z |
| format | Article |
| id | doaj.art-da42c514c65f4a74a9d322921eebda40 |
| institution | Directory Open Access Journal |
| issn | 1757-7853 1757-7861 |
| language | English |
| last_indexed | 2024-12-16T14:53:26Z |
| publishDate | 2019-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Orthopaedic Surgery |
| spelling | doaj.art-da42c514c65f4a74a9d322921eebda402022-12-21T22:27:32ZengWileyOrthopaedic Surgery1757-78531757-78612019-12-011161020102810.1111/os.12566Surgical Outcomes and Prognostic Factors of Myxoid Liposarcoma in Extremities: A Retrospective StudyKai Zheng0Xiu‐chun Yu1Ming Xu2Yang Yang3Department of Orthopaedics The 960th Hospital of the PLA Joint Logistice Support Force Jinan ChinaDepartment of Orthopaedics The 960th Hospital of the PLA Joint Logistice Support Force Jinan ChinaDepartment of Orthopaedics The 960th Hospital of the PLA Joint Logistice Support Force Jinan ChinaDepartment of Orthopaedics The 960th Hospital of the PLA Joint Logistice Support Force Jinan ChinaObjectives To evaluate treatments and prognostic factors for the myxoid liposarcoma in extremities. Methods We retrospectively reviewed 34 patients histologically diagnosed with myxoid liposarcoma arising in the extremities, treated in our hospital from 2010 to 2017. We recorded tumor locations, max diameter, operations, complications, radiation, chemotherapy, survival, recrudescence, and metastases. Overall survival, treatments, and prognostic factors were subsequently analyzed. Results The mean age of 34 patients with myxoid liposarcoma in extremities was 49.1 years, and the mean follow‐up period was 65.1 months. The median survival time was 190 months. Five of 14 patients accepted recrudescence resection and two patients of 20 patients who underwent primary tumor resection or unplanned operation died of tumor progression. Although no statistical difference was found (X 2 = 3.331, P = 0.068), the lower mortality was confirmed in the patients who accepted primary tumor resection or unplanned operation. Eleven patients with a tumor diameter of 8.6 ± 4.7 cm accepted wide resection, while 23 patients with 17.2 ± 8.8 cm tumors accepted marginal resection. Statistical difference was found between the size of tumors with relatively wide resection and those with relatively marginal resection (F = 9.130, P = 0.005). No recurrence or metastasis occurred in patients who accepted wide resection, while 14 patients presented with local recurrence and 8 patients developed distant metastases among the 23 patients with marginal resection. Seven patients died of metastases, while one patient lived with metastases. No significant difference in survival was found between different surgical methods (X 2 = 0.9460, P = 0.3307). The average diameter of eight patients with distant metastases was 21.7 cm, which was considerable larger than the 12.1 cm of patients without metastasis. This difference was proven significant upon the statistical analysis (F = 9.412, P = 0.004). Conclusions Wide resection achieved good local control but was not unambiguously superior in long‐term survival. Myxoid liposarcoma tumors with larger diameters were more difficult to be submitted to wide resection and were more likely to present with distant metastasis.https://doi.org/10.1111/os.12566ExtremitiesMyxoid liposarcomaPrognostic factorsSurgical outcome |
| spellingShingle | Kai Zheng Xiu‐chun Yu Ming Xu Yang Yang Surgical Outcomes and Prognostic Factors of Myxoid Liposarcoma in Extremities: A Retrospective Study Orthopaedic Surgery Extremities Myxoid liposarcoma Prognostic factors Surgical outcome |
| title | Surgical Outcomes and Prognostic Factors of Myxoid Liposarcoma in Extremities: A Retrospective Study |
| title_full | Surgical Outcomes and Prognostic Factors of Myxoid Liposarcoma in Extremities: A Retrospective Study |
| title_fullStr | Surgical Outcomes and Prognostic Factors of Myxoid Liposarcoma in Extremities: A Retrospective Study |
| title_full_unstemmed | Surgical Outcomes and Prognostic Factors of Myxoid Liposarcoma in Extremities: A Retrospective Study |
| title_short | Surgical Outcomes and Prognostic Factors of Myxoid Liposarcoma in Extremities: A Retrospective Study |
| title_sort | surgical outcomes and prognostic factors of myxoid liposarcoma in extremities a retrospective study |
| topic | Extremities Myxoid liposarcoma Prognostic factors Surgical outcome |
| url | https://doi.org/10.1111/os.12566 |
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