The anti ulcer effect of omeprazole is modified by Nigella sativa (Black Cumin) in ethanol induced gastric ulceration in rabbits
Background: An interaction has been reported between Nigella Sativa (NS) and ranitidine (RAN) on gastric ulceration induced by ethanol in rabbits; the combination NS and RAN caused disappearance of anti-ulcer effect of NS or RAN. <br /> Objective: to investigate interaction of NS with a proton...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
University of Basrah
2020-12-01
|
| Series: | The Medical Journal of Basrah University |
| Subjects: | |
| Online Access: | https://mjbu.uobasrah.edu.iq/article_167358_a30f9f545b7052a0452c02865d4caf9a.pdf |
| _version_ | 1818787606463250432 |
|---|---|
| author | Jawad Ahmed Ali Al-Rawaq |
| author_facet | Jawad Ahmed Ali Al-Rawaq |
| author_sort | Jawad Ahmed |
| collection | DOAJ |
| description | Background: An interaction has been reported between Nigella Sativa (NS) and ranitidine (RAN) on gastric ulceration induced by ethanol in rabbits; the combination NS and RAN caused disappearance of anti-ulcer effect of NS or RAN. <br /> Objective: to investigate interaction of NS with a proton pump inhibitor omeprazole (OMP) on ethanol induced gastric ulceration in rabbits.<br /> Methods: 24 mature rabbits were divided into 4 groups. The animals were fasted for 48 hours then treated as follow: group 1, 2, 3 and 4 were treated respectively with normal saline (oral), NS oil (10ml/kg) orally, OMP (20mg/kg) IP, and NS+ OMP. One hour later, animals were given absolute ethanol orally; and sacrificed 3 hours later for estimation of Ulcer index (UI), gastric pH, malondialdehyde (MDA), glutathione (GSH), histamine (HIS) levels in serum and gastric tissue.<br /> Results: Ethanol induced gastric ulceration in all animals with an UI of 10 ± 0.11 mm2. This effect was paralleled with reduction in gastric pH, increased MDA and HIS and reduction in GSH. UI was reduced to 5.13 ± 0.68 mm2 in NS group, P value = 0.07 and to around zero in OMP group. NS or OMP treatment resulted in reduction in serum and tissue MDA and HIS levels and increased in GSH and gastric pH levels. In NS + OMP treated group, UI became higher than OMP group with MDA and HIS tended to rise and GSH and gastric pH declined. <br /> Conclusion: NS + OMP diminished the gastro-protective effect of either NS or OMP. |
| first_indexed | 2024-12-18T14:10:27Z |
| format | Article |
| id | doaj.art-da431cd0d6df43738784c7bc816102ee |
| institution | Directory Open Access Journal |
| issn | 0253-0759 2413-4414 |
| language | English |
| last_indexed | 2024-12-18T14:10:27Z |
| publishDate | 2020-12-01 |
| publisher | University of Basrah |
| record_format | Article |
| series | The Medical Journal of Basrah University |
| spelling | doaj.art-da431cd0d6df43738784c7bc816102ee2022-12-21T21:05:08ZengUniversity of BasrahThe Medical Journal of Basrah University0253-07592413-44142020-12-01382859810.33762/mjbu.2020.127147.1018167358The anti ulcer effect of omeprazole is modified by Nigella sativa (Black Cumin) in ethanol induced gastric ulceration in rabbitsJawad Ahmed0Ali Al-Rawaq1Department of Pharmacology, College of Medicine, University of Basrah, IraqDepartment of Pharmacy, College of Pharmacy, University of Basrah, IraqBackground: An interaction has been reported between Nigella Sativa (NS) and ranitidine (RAN) on gastric ulceration induced by ethanol in rabbits; the combination NS and RAN caused disappearance of anti-ulcer effect of NS or RAN. <br /> Objective: to investigate interaction of NS with a proton pump inhibitor omeprazole (OMP) on ethanol induced gastric ulceration in rabbits.<br /> Methods: 24 mature rabbits were divided into 4 groups. The animals were fasted for 48 hours then treated as follow: group 1, 2, 3 and 4 were treated respectively with normal saline (oral), NS oil (10ml/kg) orally, OMP (20mg/kg) IP, and NS+ OMP. One hour later, animals were given absolute ethanol orally; and sacrificed 3 hours later for estimation of Ulcer index (UI), gastric pH, malondialdehyde (MDA), glutathione (GSH), histamine (HIS) levels in serum and gastric tissue.<br /> Results: Ethanol induced gastric ulceration in all animals with an UI of 10 ± 0.11 mm2. This effect was paralleled with reduction in gastric pH, increased MDA and HIS and reduction in GSH. UI was reduced to 5.13 ± 0.68 mm2 in NS group, P value = 0.07 and to around zero in OMP group. NS or OMP treatment resulted in reduction in serum and tissue MDA and HIS levels and increased in GSH and gastric pH levels. In NS + OMP treated group, UI became higher than OMP group with MDA and HIS tended to rise and GSH and gastric pH declined. <br /> Conclusion: NS + OMP diminished the gastro-protective effect of either NS or OMP.https://mjbu.uobasrah.edu.iq/article_167358_a30f9f545b7052a0452c02865d4caf9a.pdfnigella sativaomeprazoleherb-drug interactiongastric ulcerantioxidant |
| spellingShingle | Jawad Ahmed Ali Al-Rawaq The anti ulcer effect of omeprazole is modified by Nigella sativa (Black Cumin) in ethanol induced gastric ulceration in rabbits The Medical Journal of Basrah University nigella sativa omeprazole herb-drug interaction gastric ulcer antioxidant |
| title | The anti ulcer effect of omeprazole is modified by Nigella sativa (Black Cumin) in ethanol induced gastric ulceration in rabbits |
| title_full | The anti ulcer effect of omeprazole is modified by Nigella sativa (Black Cumin) in ethanol induced gastric ulceration in rabbits |
| title_fullStr | The anti ulcer effect of omeprazole is modified by Nigella sativa (Black Cumin) in ethanol induced gastric ulceration in rabbits |
| title_full_unstemmed | The anti ulcer effect of omeprazole is modified by Nigella sativa (Black Cumin) in ethanol induced gastric ulceration in rabbits |
| title_short | The anti ulcer effect of omeprazole is modified by Nigella sativa (Black Cumin) in ethanol induced gastric ulceration in rabbits |
| title_sort | anti ulcer effect of omeprazole is modified by nigella sativa black cumin in ethanol induced gastric ulceration in rabbits |
| topic | nigella sativa omeprazole herb-drug interaction gastric ulcer antioxidant |
| url | https://mjbu.uobasrah.edu.iq/article_167358_a30f9f545b7052a0452c02865d4caf9a.pdf |
| work_keys_str_mv | AT jawadahmed theantiulcereffectofomeprazoleismodifiedbynigellasativablackcumininethanolinducedgastriculcerationinrabbits AT alialrawaq theantiulcereffectofomeprazoleismodifiedbynigellasativablackcumininethanolinducedgastriculcerationinrabbits AT jawadahmed antiulcereffectofomeprazoleismodifiedbynigellasativablackcumininethanolinducedgastriculcerationinrabbits AT alialrawaq antiulcereffectofomeprazoleismodifiedbynigellasativablackcumininethanolinducedgastriculcerationinrabbits |