Impact of antimicrobial stewardship programs on antibiotic consumption and antimicrobial resistance in four Colombian healthcare institutions
Abstract Background Antimicrobial stewardship programs (ASPs) have become a fundamental pillar in optimizing antimicrobial usage, improving patient care, and reducing antimicrobial resistance (AMR). Herein we evaluated the impact of an ASP on antimicrobial consumption and AMR in Colombia. Methods We...
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-022-07410-6 |
| _version_ | 1818251073617395712 |
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| author | Christian Pallares Cristhian Hernández-Gómez Tobías Manuel Appel Kevin Escandón Sergio Reyes Soraya Salcedo Lorena Matta Ernesto Martínez Sara Cobo Laura Mora Adriana Marín Adriana Correa Elsa De La Cadena Jesús Rodríguez-Baño María Virginia Villegas |
| author_facet | Christian Pallares Cristhian Hernández-Gómez Tobías Manuel Appel Kevin Escandón Sergio Reyes Soraya Salcedo Lorena Matta Ernesto Martínez Sara Cobo Laura Mora Adriana Marín Adriana Correa Elsa De La Cadena Jesús Rodríguez-Baño María Virginia Villegas |
| author_sort | Christian Pallares |
| collection | DOAJ |
| description | Abstract Background Antimicrobial stewardship programs (ASPs) have become a fundamental pillar in optimizing antimicrobial usage, improving patient care, and reducing antimicrobial resistance (AMR). Herein we evaluated the impact of an ASP on antimicrobial consumption and AMR in Colombia. Methods We designed a retrospective observational study and measured trends in antibiotic consumption and AMR before and after the implementation of an ASP using interrupted time series analysis over a 4-year period (24 months before and 24 months after ASP implementation). Results ASPs were implemented according to the available resources in each of the institutions. Before ASP implementation, there was a trend toward an increase in the antibiotic consumption of all measured antimicrobials selected. Afterward, an overall decrease in antibiotic consumption was observed. The use of ertapenem and meropenem decreased in hospital wards, while a decrease in the use of ceftriaxone, cefepime, piperacillin/tazobactam, meropenem, and vancomycin was observed in intensive care units. After ASP implementation, the trend toward an increase of oxacillin-resistant Staphylococcus aureus, ceftriaxone-resistant Escherichia coli, and meropenem-resistant Pseudomonas aeruginosa was reversed. Conclusions In our study, we showed that ASPs are a key strategy in tackling the emerging threat of AMR and have a positive impact on antibiotic consumption and resistance. |
| first_indexed | 2024-12-12T16:02:29Z |
| format | Article |
| id | doaj.art-da43c11f6de0408bb667ba0821c905ae |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-12T16:02:29Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-da43c11f6de0408bb667ba0821c905ae2022-12-22T00:19:23ZengBMCBMC Infectious Diseases1471-23342022-05-012211810.1186/s12879-022-07410-6Impact of antimicrobial stewardship programs on antibiotic consumption and antimicrobial resistance in four Colombian healthcare institutionsChristian Pallares0Cristhian Hernández-Gómez1Tobías Manuel Appel2Kevin Escandón3Sergio Reyes4Soraya Salcedo5Lorena Matta6Ernesto Martínez7Sara Cobo8Laura Mora9Adriana Marín10Adriana Correa11Elsa De La Cadena12Jesús Rodríguez-Baño13María Virginia Villegas14Grupo de Investigaciones en Resistencia Antimicrobiana y Epidemiología Hospitalaria (RAEH), Universidad el BosqueGrupo de Investigaciones en Resistencia Antimicrobiana y Epidemiología Hospitalaria (RAEH), Universidad el BosqueGrupo de Investigaciones en Resistencia Antimicrobiana y Epidemiología Hospitalaria (RAEH), Universidad el BosqueCentro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM)Centro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM)Clínica General del NorteCorporación Clínica Universitaria ComfenalcoUniversidad del ValleDIME Clínica NeurocardiovascularClínica General del NorteClínica General del NorteCentro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM)Grupo de Investigaciones en Resistencia Antimicrobiana y Epidemiología Hospitalaria (RAEH), Universidad el BosqueUnidad Clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen MacarenaGrupo de Investigaciones en Resistencia Antimicrobiana y Epidemiología Hospitalaria (RAEH), Universidad el BosqueAbstract Background Antimicrobial stewardship programs (ASPs) have become a fundamental pillar in optimizing antimicrobial usage, improving patient care, and reducing antimicrobial resistance (AMR). Herein we evaluated the impact of an ASP on antimicrobial consumption and AMR in Colombia. Methods We designed a retrospective observational study and measured trends in antibiotic consumption and AMR before and after the implementation of an ASP using interrupted time series analysis over a 4-year period (24 months before and 24 months after ASP implementation). Results ASPs were implemented according to the available resources in each of the institutions. Before ASP implementation, there was a trend toward an increase in the antibiotic consumption of all measured antimicrobials selected. Afterward, an overall decrease in antibiotic consumption was observed. The use of ertapenem and meropenem decreased in hospital wards, while a decrease in the use of ceftriaxone, cefepime, piperacillin/tazobactam, meropenem, and vancomycin was observed in intensive care units. After ASP implementation, the trend toward an increase of oxacillin-resistant Staphylococcus aureus, ceftriaxone-resistant Escherichia coli, and meropenem-resistant Pseudomonas aeruginosa was reversed. Conclusions In our study, we showed that ASPs are a key strategy in tackling the emerging threat of AMR and have a positive impact on antibiotic consumption and resistance.https://doi.org/10.1186/s12879-022-07410-6Antimicrobial stewardshipAntimicrobial stewardship programAntimicrobial resistanceAntibiotic resistanceHospital epidemiologyColombia |
| spellingShingle | Christian Pallares Cristhian Hernández-Gómez Tobías Manuel Appel Kevin Escandón Sergio Reyes Soraya Salcedo Lorena Matta Ernesto Martínez Sara Cobo Laura Mora Adriana Marín Adriana Correa Elsa De La Cadena Jesús Rodríguez-Baño María Virginia Villegas Impact of antimicrobial stewardship programs on antibiotic consumption and antimicrobial resistance in four Colombian healthcare institutions BMC Infectious Diseases Antimicrobial stewardship Antimicrobial stewardship program Antimicrobial resistance Antibiotic resistance Hospital epidemiology Colombia |
| title | Impact of antimicrobial stewardship programs on antibiotic consumption and antimicrobial resistance in four Colombian healthcare institutions |
| title_full | Impact of antimicrobial stewardship programs on antibiotic consumption and antimicrobial resistance in four Colombian healthcare institutions |
| title_fullStr | Impact of antimicrobial stewardship programs on antibiotic consumption and antimicrobial resistance in four Colombian healthcare institutions |
| title_full_unstemmed | Impact of antimicrobial stewardship programs on antibiotic consumption and antimicrobial resistance in four Colombian healthcare institutions |
| title_short | Impact of antimicrobial stewardship programs on antibiotic consumption and antimicrobial resistance in four Colombian healthcare institutions |
| title_sort | impact of antimicrobial stewardship programs on antibiotic consumption and antimicrobial resistance in four colombian healthcare institutions |
| topic | Antimicrobial stewardship Antimicrobial stewardship program Antimicrobial resistance Antibiotic resistance Hospital epidemiology Colombia |
| url | https://doi.org/10.1186/s12879-022-07410-6 |
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