Clinical features of cardiac lesion in patients with generalized sarcoidosis
The article presents a clinical observation of two patients with generalized sarcoidosis. The woman typical granulomatous changes in the lungs and lymph nodes combined with atrial fibrillation, kidney failure and hereditary thrombophilia, men with atherosclerotic coronary arteries, re-myocardial inf...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
"Consilium Medicum" Publishing house
2018-01-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | http://ter-arkhiv.ru/en/archive/2018/vol-90_1_2018/klinicheskie-osobennosti-porazheniya-serdtsa-pri-generalizovannom-sarkoidoze_526/?element |
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| author | E.N. POPOVA L.A. STRIZHAKOV V.I. SHOLOMOVA A.B. PONOMAREV S.V. MOISEEV M.U. BROVKO I.B. BONDARENKO L.A. PONOMAREVA V.V. FOMIN |
| author_facet | E.N. POPOVA L.A. STRIZHAKOV V.I. SHOLOMOVA A.B. PONOMAREV S.V. MOISEEV M.U. BROVKO I.B. BONDARENKO L.A. PONOMAREVA V.V. FOMIN |
| author_sort | E.N. POPOVA |
| collection | DOAJ |
| description | The article presents a clinical observation of two patients with generalized sarcoidosis. The woman typical granulomatous changes in the lungs and lymph nodes combined with atrial fibrillation, kidney failure and hereditary thrombophilia, men with atherosclerotic coronary arteries, re-myocardial infarction, cholestasis, tubulointerstitial nephritis. The accession of systemic manifestations was accompanied by increase of level of angiotensin-converting enzyme in the blood serum, morphological examination of lung tissue in both cases there were high histological activity of vasculitis and granulomatous inflammation. Extrapulmonary symptoms regressed when conducting immunosuppressive therapy. Discusses modern aspects of diagnosis of sarcoidosis in clinical practice. |
| first_indexed | 2024-12-13T17:21:45Z |
| format | Article |
| id | doaj.art-da44676063154f5597aa82bed3b2f8c3 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-13T17:21:45Z |
| publishDate | 2018-01-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-da44676063154f5597aa82bed3b2f8c32022-12-21T23:37:17Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422018-01-01901545910.26442/terarkh201890154-59Clinical features of cardiac lesion in patients with generalized sarcoidosisE.N. POPOVA0L.A. STRIZHAKOV1V.I. SHOLOMOVA2A.B. PONOMAREV3S.V. MOISEEV4M.U. BROVKO5I.B. BONDARENKO6L.A. PONOMAREVA7V.V. FOMIN8I.M. Sechenov First Moscow State Medical University, Faculty of Medicine, Chair of Internal Medicine No.1, Moscow, RussiaI.M. Sechenov First Moscow State Medical University, Faculty of Medicine, Chair of Internal Medicine No.1, Moscow, RussiaI.M. Sechenov First Moscow State Medical University, Faculty of Medicine, Chair of Internal Medicine No.1, Moscow, RussiaI.M. Sechenov First Moscow State Medical University, Faculty of Medicine, Chair of Internal Medicine No.1, Moscow, RussiaI.M. Sechenov First Moscow State Medical University, Faculty of Medicine, Chair of Internal Medicine No.1, Moscow, RussiaI.M. Sechenov First Moscow State Medical University, Faculty of Medicine, Chair of Internal Medicine No.1, Moscow, RussiaI.M. Sechenov First Moscow State Medical University, Faculty of Medicine, Chair of Internal Medicine No.1, Moscow, RussiaI.M. Sechenov First Moscow State Medical University, Faculty of Medicine, Chair of Internal Medicine No.1, Moscow, RussiaI.M. Sechenov First Moscow State Medical University, Faculty of Medicine, Chair of Internal Medicine No.1, Moscow, RussiaThe article presents a clinical observation of two patients with generalized sarcoidosis. The woman typical granulomatous changes in the lungs and lymph nodes combined with atrial fibrillation, kidney failure and hereditary thrombophilia, men with atherosclerotic coronary arteries, re-myocardial infarction, cholestasis, tubulointerstitial nephritis. The accession of systemic manifestations was accompanied by increase of level of angiotensin-converting enzyme in the blood serum, morphological examination of lung tissue in both cases there were high histological activity of vasculitis and granulomatous inflammation. Extrapulmonary symptoms regressed when conducting immunosuppressive therapy. Discusses modern aspects of diagnosis of sarcoidosis in clinical practice.http://ter-arkhiv.ru/en/archive/2018/vol-90_1_2018/klinicheskie-osobennosti-porazheniya-serdtsa-pri-generalizovannom-sarkoidoze_526/?elementsarcoidosisextrapulmonary manifestation of sarcoidosiscardiomyopathycardiac rhythm disorderatherosclerosis |
| spellingShingle | E.N. POPOVA L.A. STRIZHAKOV V.I. SHOLOMOVA A.B. PONOMAREV S.V. MOISEEV M.U. BROVKO I.B. BONDARENKO L.A. PONOMAREVA V.V. FOMIN Clinical features of cardiac lesion in patients with generalized sarcoidosis Терапевтический архив sarcoidosis extrapulmonary manifestation of sarcoidosis cardiomyopathy cardiac rhythm disorder atherosclerosis |
| title | Clinical features of cardiac lesion in patients with generalized sarcoidosis |
| title_full | Clinical features of cardiac lesion in patients with generalized sarcoidosis |
| title_fullStr | Clinical features of cardiac lesion in patients with generalized sarcoidosis |
| title_full_unstemmed | Clinical features of cardiac lesion in patients with generalized sarcoidosis |
| title_short | Clinical features of cardiac lesion in patients with generalized sarcoidosis |
| title_sort | clinical features of cardiac lesion in patients with generalized sarcoidosis |
| topic | sarcoidosis extrapulmonary manifestation of sarcoidosis cardiomyopathy cardiac rhythm disorder atherosclerosis |
| url | http://ter-arkhiv.ru/en/archive/2018/vol-90_1_2018/klinicheskie-osobennosti-porazheniya-serdtsa-pri-generalizovannom-sarkoidoze_526/?element |
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