Obesity is associated with myelin oligodendrocyte glycoprotein antibody-associated disease in acute optic neuritis
Abstract Optic neuritis (ON) is a frequent presentation at onset of multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). The pathophysiology underlying these diseases, especially MOGAD, is still being el...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-21592-8 |
| _version_ | 1797865152632061952 |
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| author | Hadas Stiebel-Kalish Kerstin Rubarth Karny Shouchane-Blum Alon Tiosano Itay Lotan Mark A. Hellmann Adi Wilf-Yarkoni Omer Bialer Eoin P. Flanagan Sean J. Pittock M. Tariq Bhatti Tanja Schmitz-Hübsch Friedemann Paul Susanna Asseyer John J. Chen |
| author_facet | Hadas Stiebel-Kalish Kerstin Rubarth Karny Shouchane-Blum Alon Tiosano Itay Lotan Mark A. Hellmann Adi Wilf-Yarkoni Omer Bialer Eoin P. Flanagan Sean J. Pittock M. Tariq Bhatti Tanja Schmitz-Hübsch Friedemann Paul Susanna Asseyer John J. Chen |
| author_sort | Hadas Stiebel-Kalish |
| collection | DOAJ |
| description | Abstract Optic neuritis (ON) is a frequent presentation at onset of multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). The pathophysiology underlying these diseases, especially MOGAD, is still being elucidated. While obesity has been reported to potentially be a risk factor for MS, this has not been explored in NMOSD or MOGAD. We aimed to investigate a possible association between obesity (body mass index [BMI] > 30 kg/m2) in patients with MOGAD, aquaporin 4-IgG positive NMOSD (AQP4-IgG+ NMOSD) or MS. In this multicenter non-interventional retrospective study, data was collected from patients with a first ever demyelinating attack of ON subsequently diagnosed with MOGAD (n = 44), AQP4-IgG+ NMOSD (n = 49) or MS (n = 90) between 2005 and 2020. The following data was collected: age, sex, ethnicity, BMI (documented before corticosteroid treatment), and the ON etiology after diagnostic work-up. A mixed model analysis was performed to assess the potential of obesity or BMI to predict MOGAD-ON, and to distinguish MOGAD-ON from AQP4-IgG+ NMOSD-ON and MS-ON. Main outcome measures included BMI in patients with acute ON and subsequent diagnosis of MOGAD, AQP4-IgG+ NMOSD or MS. A higher BMI was significantly associated with a diagnosis of MOGAD-ON (p < 0.001); in MOGAD patients the mean BMI was 31.6 kg/m2 (standard deviation (SD) 7.2), while the mean BMI was 24.7 kg/m2 (SD 5.3) in AQP4-IgG+ NMOSD patients, and 26.9 kg/m2 (SD 6.2) in MS patients. Mixed-effects multinomial logistic regression, adjusted for age and sex, with obesity as a binary variable, revealed that obesity was associated with a higher odds ratio (OR) of a subsequent MOGAD diagnosis (OR 5.466, 95% CI [2.039, 14.650], p = 0.001) in contradistinction with AQP4-IgG+ NMOSD. This study suggests an association between obesity and MOGAD. Our findings require further exploration, but could have significant pathophysiologic implications if confirmed in larger prospective studies. |
| first_indexed | 2024-04-09T23:03:20Z |
| format | Article |
| id | doaj.art-da44a71eedc346e4aea29ab72bece8c0 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T23:03:20Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-da44a71eedc346e4aea29ab72bece8c02023-03-22T10:50:48ZengNature PortfolioScientific Reports2045-23222022-12-011211710.1038/s41598-022-21592-8Obesity is associated with myelin oligodendrocyte glycoprotein antibody-associated disease in acute optic neuritisHadas Stiebel-Kalish0Kerstin Rubarth1Karny Shouchane-Blum2Alon Tiosano3Itay Lotan4Mark A. Hellmann5Adi Wilf-Yarkoni6Omer Bialer7Eoin P. Flanagan8Sean J. Pittock9M. Tariq Bhatti10Tanja Schmitz-Hübsch11Friedemann Paul12Susanna Asseyer13John J. Chen14Sackler Faculty of Medicine, Tel Aviv UniversityInstitute of Biometry and Clinical Epidemiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt Universität zu BerlinSackler Faculty of Medicine, Tel Aviv UniversitySackler Faculty of Medicine, Tel Aviv UniversitySackler Faculty of Medicine, Tel Aviv UniversityDepartment of Neurology, Rabin Medical Center, Beilinson HospitalDepartment of Neurology, Rabin Medical Center, Beilinson HospitalSackler Faculty of Medicine, Tel Aviv UniversityDepartments of Ophthalmology and Neurology, Mayo ClinicDepartments of Ophthalmology and Neurology, Mayo ClinicDepartment of Neurology, Laboratory Medicine and Pathology, Center for MS and Autoimmune Neurology, Mayo ClinicExperimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of HealthExperimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of HealthExperimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of HealthDepartments of Ophthalmology and Neurology, Mayo ClinicAbstract Optic neuritis (ON) is a frequent presentation at onset of multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). The pathophysiology underlying these diseases, especially MOGAD, is still being elucidated. While obesity has been reported to potentially be a risk factor for MS, this has not been explored in NMOSD or MOGAD. We aimed to investigate a possible association between obesity (body mass index [BMI] > 30 kg/m2) in patients with MOGAD, aquaporin 4-IgG positive NMOSD (AQP4-IgG+ NMOSD) or MS. In this multicenter non-interventional retrospective study, data was collected from patients with a first ever demyelinating attack of ON subsequently diagnosed with MOGAD (n = 44), AQP4-IgG+ NMOSD (n = 49) or MS (n = 90) between 2005 and 2020. The following data was collected: age, sex, ethnicity, BMI (documented before corticosteroid treatment), and the ON etiology after diagnostic work-up. A mixed model analysis was performed to assess the potential of obesity or BMI to predict MOGAD-ON, and to distinguish MOGAD-ON from AQP4-IgG+ NMOSD-ON and MS-ON. Main outcome measures included BMI in patients with acute ON and subsequent diagnosis of MOGAD, AQP4-IgG+ NMOSD or MS. A higher BMI was significantly associated with a diagnosis of MOGAD-ON (p < 0.001); in MOGAD patients the mean BMI was 31.6 kg/m2 (standard deviation (SD) 7.2), while the mean BMI was 24.7 kg/m2 (SD 5.3) in AQP4-IgG+ NMOSD patients, and 26.9 kg/m2 (SD 6.2) in MS patients. Mixed-effects multinomial logistic regression, adjusted for age and sex, with obesity as a binary variable, revealed that obesity was associated with a higher odds ratio (OR) of a subsequent MOGAD diagnosis (OR 5.466, 95% CI [2.039, 14.650], p = 0.001) in contradistinction with AQP4-IgG+ NMOSD. This study suggests an association between obesity and MOGAD. Our findings require further exploration, but could have significant pathophysiologic implications if confirmed in larger prospective studies.https://doi.org/10.1038/s41598-022-21592-8 |
| spellingShingle | Hadas Stiebel-Kalish Kerstin Rubarth Karny Shouchane-Blum Alon Tiosano Itay Lotan Mark A. Hellmann Adi Wilf-Yarkoni Omer Bialer Eoin P. Flanagan Sean J. Pittock M. Tariq Bhatti Tanja Schmitz-Hübsch Friedemann Paul Susanna Asseyer John J. Chen Obesity is associated with myelin oligodendrocyte glycoprotein antibody-associated disease in acute optic neuritis Scientific Reports |
| title | Obesity is associated with myelin oligodendrocyte glycoprotein antibody-associated disease in acute optic neuritis |
| title_full | Obesity is associated with myelin oligodendrocyte glycoprotein antibody-associated disease in acute optic neuritis |
| title_fullStr | Obesity is associated with myelin oligodendrocyte glycoprotein antibody-associated disease in acute optic neuritis |
| title_full_unstemmed | Obesity is associated with myelin oligodendrocyte glycoprotein antibody-associated disease in acute optic neuritis |
| title_short | Obesity is associated with myelin oligodendrocyte glycoprotein antibody-associated disease in acute optic neuritis |
| title_sort | obesity is associated with myelin oligodendrocyte glycoprotein antibody associated disease in acute optic neuritis |
| url | https://doi.org/10.1038/s41598-022-21592-8 |
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