Antioxidant, Anti-Melanogenic and Anti-Wrinkle Effects of Phellinus vaninii
In this study, the antioxidant, anti-xanthine oxidase, anti-melanogenic and anti-wrinkle effects of methanol (ME) and hot water (HE) extracts from the fruiting bodies of Phellinus vaninii were investigated. The 1,1-diphenyl-2-picryl-hydrazyl free radical scavenging activity of 2.0 mg/mL HE (95.38%)...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-10-01
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| Series: | Mycobiology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/12298093.2019.1673595 |
| _version_ | 1811286084199383040 |
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| author | Kyung Hoan Im Seung A Baek Jaehyuk Choi Tae Soo Lee |
| author_facet | Kyung Hoan Im Seung A Baek Jaehyuk Choi Tae Soo Lee |
| author_sort | Kyung Hoan Im |
| collection | DOAJ |
| description | In this study, the antioxidant, anti-xanthine oxidase, anti-melanogenic and anti-wrinkle effects of methanol (ME) and hot water (HE) extracts from the fruiting bodies of Phellinus vaninii were investigated. The 1,1-diphenyl-2-picryl-hydrazyl free radical scavenging activity of 2.0 mg/mL HE (95.38%) was comparable to that of butylated hydroxytoluene (96.97%), the reference standard. The hydroxyl radical scavenging activities of ME (98.19%) and HE (97.55%) were higher than that of butylated hydroxytoluene (92.66%) at 2.0 mg/mL. Neither ME nor HE was cytotoxic to murine melanoma B16-F10 cells at 25–750 µg/mL. Although the xanthine oxidase (XO) inhibitory effects of ME and HE were significantly lower than that of allopurinol, the values were higher than 84 percent. The in vitro tyrosinase inhibitory activities of ME and HE were comparable to kojic acid at 2.0 mg/mL. The cellular tyrosinase and melanin synthetic activities of ME and HE on B16-F10 melanoma cells at 500 µg/mL were higher than arbutin, indicating that the inhibitory effects of arbutin on the tyrosinase and melanin synthesis were higher than those of ME and HE. The collagenase inhibitory activity of HE was comparable to EGCG at 2.0 mg/mL, however, the elastase inhibitory activity of ME and HE was lower than EGCG at the concentration tested. The study results demonstrated that the fruiting bodies of Ph. vaninii possessed good antioxidant, anti-xanthine oxidase, cell-free anti-tyrosinase, cellular anti-tyrosinase, anti-collagenase, and moderate anti-elastase activities, which might be used for the development of novel anti-gout, skin-whitening, and skin anti-wrinkle agents. |
| first_indexed | 2024-04-13T02:54:36Z |
| format | Article |
| id | doaj.art-da45253fb78d4532ada848e1e7744738 |
| institution | Directory Open Access Journal |
| issn | 1229-8093 2092-9323 |
| language | English |
| last_indexed | 2024-04-13T02:54:36Z |
| publishDate | 2019-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Mycobiology |
| spelling | doaj.art-da45253fb78d4532ada848e1e77447382022-12-22T03:05:43ZengTaylor & Francis GroupMycobiology1229-80932092-93232019-10-0147449450510.1080/12298093.2019.16735951673595Antioxidant, Anti-Melanogenic and Anti-Wrinkle Effects of Phellinus vaniniiKyung Hoan Im0Seung A Baek1Jaehyuk Choi2Tae Soo Lee3Incheon National UniversityIncheon National UniversityIncheon National UniversityIncheon National UniversityIn this study, the antioxidant, anti-xanthine oxidase, anti-melanogenic and anti-wrinkle effects of methanol (ME) and hot water (HE) extracts from the fruiting bodies of Phellinus vaninii were investigated. The 1,1-diphenyl-2-picryl-hydrazyl free radical scavenging activity of 2.0 mg/mL HE (95.38%) was comparable to that of butylated hydroxytoluene (96.97%), the reference standard. The hydroxyl radical scavenging activities of ME (98.19%) and HE (97.55%) were higher than that of butylated hydroxytoluene (92.66%) at 2.0 mg/mL. Neither ME nor HE was cytotoxic to murine melanoma B16-F10 cells at 25–750 µg/mL. Although the xanthine oxidase (XO) inhibitory effects of ME and HE were significantly lower than that of allopurinol, the values were higher than 84 percent. The in vitro tyrosinase inhibitory activities of ME and HE were comparable to kojic acid at 2.0 mg/mL. The cellular tyrosinase and melanin synthetic activities of ME and HE on B16-F10 melanoma cells at 500 µg/mL were higher than arbutin, indicating that the inhibitory effects of arbutin on the tyrosinase and melanin synthesis were higher than those of ME and HE. The collagenase inhibitory activity of HE was comparable to EGCG at 2.0 mg/mL, however, the elastase inhibitory activity of ME and HE was lower than EGCG at the concentration tested. The study results demonstrated that the fruiting bodies of Ph. vaninii possessed good antioxidant, anti-xanthine oxidase, cell-free anti-tyrosinase, cellular anti-tyrosinase, anti-collagenase, and moderate anti-elastase activities, which might be used for the development of novel anti-gout, skin-whitening, and skin anti-wrinkle agents.http://dx.doi.org/10.1080/12298093.2019.1673595anti-melanogenesisantioxidantanti-xanthine oxidaseskin anti-wrinklephellinus vaninii |
| spellingShingle | Kyung Hoan Im Seung A Baek Jaehyuk Choi Tae Soo Lee Antioxidant, Anti-Melanogenic and Anti-Wrinkle Effects of Phellinus vaninii Mycobiology anti-melanogenesis antioxidant anti-xanthine oxidase skin anti-wrinkle phellinus vaninii |
| title | Antioxidant, Anti-Melanogenic and Anti-Wrinkle Effects of Phellinus vaninii |
| title_full | Antioxidant, Anti-Melanogenic and Anti-Wrinkle Effects of Phellinus vaninii |
| title_fullStr | Antioxidant, Anti-Melanogenic and Anti-Wrinkle Effects of Phellinus vaninii |
| title_full_unstemmed | Antioxidant, Anti-Melanogenic and Anti-Wrinkle Effects of Phellinus vaninii |
| title_short | Antioxidant, Anti-Melanogenic and Anti-Wrinkle Effects of Phellinus vaninii |
| title_sort | antioxidant anti melanogenic and anti wrinkle effects of phellinus vaninii |
| topic | anti-melanogenesis antioxidant anti-xanthine oxidase skin anti-wrinkle phellinus vaninii |
| url | http://dx.doi.org/10.1080/12298093.2019.1673595 |
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