Microbiologic spectrum and susceptibility pattern of urinary isolates from pediatric patients in a superspecialty Hospital: A 3-year experience
Introduction: UTI causes significant child morbidity and mortality. Enterobacteriaecae are most common uropathogens. Recently Enterococcus spp, yeast and Staphylococcus aureus have emerged as paediatric uropathogens. Understanding of local susceptibility pattern guides antibiotic therapy in UTI. Thi...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Indian Journal of Health Sciences and Biomedical Research KLEU |
| Subjects: | |
| Online Access: | http://www.ijournalhs.org/article.asp?issn=2542-6214;year=2016;volume=9;issue=2;spage=137;epage=141;aulast=Sharma |
| _version_ | 1819226374793068544 |
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| author | Abha Sharma Bibhabati Mishra Vinita Dogra |
| author_facet | Abha Sharma Bibhabati Mishra Vinita Dogra |
| author_sort | Abha Sharma |
| collection | DOAJ |
| description | Introduction: UTI causes significant child morbidity and mortality. Enterobacteriaecae are most common uropathogens. Recently Enterococcus spp, yeast and Staphylococcus aureus have emerged as paediatric uropathogens. Understanding of local susceptibility pattern guides antibiotic therapy in UTI. This study describes demographic and susceptibility profile of uropathogens in children.
Method: The urinary isolates were analysed retrospectively and data on age, sex, result of urine culture, etiological agent and susceptibility pattern were obtained from laboratory record books.
Result: 315 urine samples analysed showed 34% significant bacteruria. Prevalence of UTI among male and female children was 62% and 37.9% respectively, statistically significant (P= .0329). Predominant uropathogens were Klebsiella spp. (66.6%), Escherichia coli (25.9%), Candida albicans (20.3%) and Enterococcus spp (15.7%). Bacteruria with pyuria was 26.03%. Sterile pyuria present in 9.52% of cases. A statistically significant correlation between Pseudomonas and pyuria was noted. Both Klebsiella spp and E coli were least susceptible to augmentin and cephalosporins (25%) and most susceptible to carbapenems. Proteus spp was most susceptible to aminoglycosides (75%) and Acinetobacter spp to Piperacillin-tazobactam (83.3%) while Pseudomonas to carbapenem (75%). Acinetobacter was most resistant with 100% resistance to augmentin, cephalosporins, aminoglycosides, fluoroquinolones and nitrofurantoin. All GNRs were 100% resistant to nitrofurantoin except E coli (39.2%) and Klebsiella spp (41.6% ) susceptible. Enterococcus were 100% sensitive while 87.5% of Staphylococcus aureus were sensitive to teicoplanin and linezolid.
Conclusion: Ongoing monitoring should note any changes in paediatric uropathogens and their antibiotic resistance pattern to guide the clinicians for proper empirical management of UTI in children. |
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| institution | Directory Open Access Journal |
| issn | 2542-6214 2542-6222 |
| language | English |
| last_indexed | 2024-12-23T10:24:29Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
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| series | Indian Journal of Health Sciences and Biomedical Research KLEU |
| spelling | doaj.art-da46f0d5ee914665845eb1105bd3806f2022-12-21T17:50:37ZengWolters Kluwer Medknow PublicationsIndian Journal of Health Sciences and Biomedical Research KLEU2542-62142542-62222016-01-019213714110.4103/2349-5006.191249Microbiologic spectrum and susceptibility pattern of urinary isolates from pediatric patients in a superspecialty Hospital: A 3-year experienceAbha SharmaBibhabati MishraVinita DograIntroduction: UTI causes significant child morbidity and mortality. Enterobacteriaecae are most common uropathogens. Recently Enterococcus spp, yeast and Staphylococcus aureus have emerged as paediatric uropathogens. Understanding of local susceptibility pattern guides antibiotic therapy in UTI. This study describes demographic and susceptibility profile of uropathogens in children. Method: The urinary isolates were analysed retrospectively and data on age, sex, result of urine culture, etiological agent and susceptibility pattern were obtained from laboratory record books. Result: 315 urine samples analysed showed 34% significant bacteruria. Prevalence of UTI among male and female children was 62% and 37.9% respectively, statistically significant (P= .0329). Predominant uropathogens were Klebsiella spp. (66.6%), Escherichia coli (25.9%), Candida albicans (20.3%) and Enterococcus spp (15.7%). Bacteruria with pyuria was 26.03%. Sterile pyuria present in 9.52% of cases. A statistically significant correlation between Pseudomonas and pyuria was noted. Both Klebsiella spp and E coli were least susceptible to augmentin and cephalosporins (25%) and most susceptible to carbapenems. Proteus spp was most susceptible to aminoglycosides (75%) and Acinetobacter spp to Piperacillin-tazobactam (83.3%) while Pseudomonas to carbapenem (75%). Acinetobacter was most resistant with 100% resistance to augmentin, cephalosporins, aminoglycosides, fluoroquinolones and nitrofurantoin. All GNRs were 100% resistant to nitrofurantoin except E coli (39.2%) and Klebsiella spp (41.6% ) susceptible. Enterococcus were 100% sensitive while 87.5% of Staphylococcus aureus were sensitive to teicoplanin and linezolid. Conclusion: Ongoing monitoring should note any changes in paediatric uropathogens and their antibiotic resistance pattern to guide the clinicians for proper empirical management of UTI in children.http://www.ijournalhs.org/article.asp?issn=2542-6214;year=2016;volume=9;issue=2;spage=137;epage=141;aulast=SharmaChildrenurinary tract infectionuropathogens |
| spellingShingle | Abha Sharma Bibhabati Mishra Vinita Dogra Microbiologic spectrum and susceptibility pattern of urinary isolates from pediatric patients in a superspecialty Hospital: A 3-year experience Indian Journal of Health Sciences and Biomedical Research KLEU Children urinary tract infection uropathogens |
| title | Microbiologic spectrum and susceptibility pattern of urinary isolates from pediatric patients in a superspecialty Hospital: A 3-year experience |
| title_full | Microbiologic spectrum and susceptibility pattern of urinary isolates from pediatric patients in a superspecialty Hospital: A 3-year experience |
| title_fullStr | Microbiologic spectrum and susceptibility pattern of urinary isolates from pediatric patients in a superspecialty Hospital: A 3-year experience |
| title_full_unstemmed | Microbiologic spectrum and susceptibility pattern of urinary isolates from pediatric patients in a superspecialty Hospital: A 3-year experience |
| title_short | Microbiologic spectrum and susceptibility pattern of urinary isolates from pediatric patients in a superspecialty Hospital: A 3-year experience |
| title_sort | microbiologic spectrum and susceptibility pattern of urinary isolates from pediatric patients in a superspecialty hospital a 3 year experience |
| topic | Children urinary tract infection uropathogens |
| url | http://www.ijournalhs.org/article.asp?issn=2542-6214;year=2016;volume=9;issue=2;spage=137;epage=141;aulast=Sharma |
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