The Сharacter and Development of photoreceptors photodegeneration combined with alloxan diabetes
The aim of the research is to determine the character and development of a alterations in photoreceptors, caused by high-intensity light on the early stage of diabetes mellitus. The methods of light and electron microscopy were used. Experiments were obtained from 80 adult white male rats. The rats...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2002-06-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/3949 |
| _version_ | 1827992106016178176 |
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| author | S. V. Logvinov E. Yu. Varakuta A. V. Potapov |
| author_facet | S. V. Logvinov E. Yu. Varakuta A. V. Potapov |
| author_sort | S. V. Logvinov |
| collection | DOAJ |
| description | The aim of the research is to determine the character and development of a alterations in photoreceptors, caused by high-intensity light on the early stage of diabetes mellitus. The methods of light and electron microscopy were used. Experiments were obtained from 80 adult white male rats. The rats of group 1 (n = 20) received 1 injection of alloxan (15 mg per 100 g of weight) in order to model diabetes mellitus. The rats of group 2 (n = 20) were exposed for light of luminecent LB-40 lamps (6000 lx) for 6 hours. The rats of group 3 (n = 20) were exposed to the light with the same parameters 1 month after alloxan injection. The last 20 rats made a control group 4. The rats groups 2 and 3 were sacrifised by decapitation 1, 7, 14, 30 days after the light exposure, the rats of group 1 on the 4, 5, 6, 8 week after the alloxan injection. Light exposure combined with diabetes causes destruction pigment epithelium inner and outer processed of photoreceptors followed by pyknosis of nucleus and replacement by vacial glia. On the 7th day after the exposure local disappearance of according retinal layers was obsevred. In these local sites of the most intensive destruction in group 3 there is 1,6 times more cells with caryopyknosis from in according sites of group 2 (just light exposure) rats. Thus, alloxan diabetes on the early stage of its development (1 month) intensifies light damage of retinal photoreceptors. Probably, increase of oxydative processes and antioxidative systems break down play an important role in this synergetic effect. |
| first_indexed | 2024-04-10T01:15:42Z |
| format | Article |
| id | doaj.art-da489003ab6c4a3ca60ff240f894c989 |
| institution | Directory Open Access Journal |
| issn | 1682-0363 1819-3684 |
| language | English |
| last_indexed | 2024-04-10T01:15:42Z |
| publishDate | 2002-06-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj.art-da489003ab6c4a3ca60ff240f894c9892023-03-13T09:58:01ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842002-06-0112475210.20538/1682-0363-2002-2-47-522554The Сharacter and Development of photoreceptors photodegeneration combined with alloxan diabetesS. V. Logvinov0E. Yu. Varakuta1A. V. Potapov2Сибирский государственный медицинский университетСибирский государственный медицинский университетСибирский государственный медицинский университетThe aim of the research is to determine the character and development of a alterations in photoreceptors, caused by high-intensity light on the early stage of diabetes mellitus. The methods of light and electron microscopy were used. Experiments were obtained from 80 adult white male rats. The rats of group 1 (n = 20) received 1 injection of alloxan (15 mg per 100 g of weight) in order to model diabetes mellitus. The rats of group 2 (n = 20) were exposed for light of luminecent LB-40 lamps (6000 lx) for 6 hours. The rats of group 3 (n = 20) were exposed to the light with the same parameters 1 month after alloxan injection. The last 20 rats made a control group 4. The rats groups 2 and 3 were sacrifised by decapitation 1, 7, 14, 30 days after the light exposure, the rats of group 1 on the 4, 5, 6, 8 week after the alloxan injection. Light exposure combined with diabetes causes destruction pigment epithelium inner and outer processed of photoreceptors followed by pyknosis of nucleus and replacement by vacial glia. On the 7th day after the exposure local disappearance of according retinal layers was obsevred. In these local sites of the most intensive destruction in group 3 there is 1,6 times more cells with caryopyknosis from in according sites of group 2 (just light exposure) rats. Thus, alloxan diabetes on the early stage of its development (1 month) intensifies light damage of retinal photoreceptors. Probably, increase of oxydative processes and antioxidative systems break down play an important role in this synergetic effect.https://bulletin.ssmu.ru/jour/article/view/3949нейросенсорные клеткисахарный диабетсвет |
| spellingShingle | S. V. Logvinov E. Yu. Varakuta A. V. Potapov The Сharacter and Development of photoreceptors photodegeneration combined with alloxan diabetes Бюллетень сибирской медицины нейросенсорные клетки сахарный диабет свет |
| title | The Сharacter and Development of photoreceptors photodegeneration combined with alloxan diabetes |
| title_full | The Сharacter and Development of photoreceptors photodegeneration combined with alloxan diabetes |
| title_fullStr | The Сharacter and Development of photoreceptors photodegeneration combined with alloxan diabetes |
| title_full_unstemmed | The Сharacter and Development of photoreceptors photodegeneration combined with alloxan diabetes |
| title_short | The Сharacter and Development of photoreceptors photodegeneration combined with alloxan diabetes |
| title_sort | сharacter and development of photoreceptors photodegeneration combined with alloxan diabetes |
| topic | нейросенсорные клетки сахарный диабет свет |
| url | https://bulletin.ssmu.ru/jour/article/view/3949 |
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