Human Coronavirus: Envelope Protein Evolution
Envelope protein of human coronavirus play significant role in an evolution and mutation of the virus life cycle. In the present research, the author evaluated amino acid sequences, its abundance and GC content of the genes that corresponds to envelope proteins’ of the human coronaviruses, identifie...
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| Format: | Article |
| Language: | English |
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Journal of Pure and Applied Microbiology
2021-06-01
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| Series: | Journal of Pure and Applied Microbiology |
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| Online Access: | https://microbiologyjournal.org/human-coronavirus-envelope-protein-evolution/ |
| Summary: | Envelope protein of human coronavirus play significant role in an evolution and mutation of the virus life cycle. In the present research, the author evaluated amino acid sequences, its abundance and GC content of the genes that corresponds to envelope proteins’ of the human coronaviruses, identified from year 2003-2019. It includes SARS-CoV (2003), HCoV-NL-63 (2003), HCoV-HKU-1 (2004), MERS-CoV (2013), and SARS-CoV-2 (2019). The present research findings illustrated a point mutation in D2 location of SARS-CoV-2 (2019), representing Arginine in the place of Glutamic acid (SARS-CoV, 2003) where glycine was found deleted. SARS-CoV-2 (2019) coronavirus revealed increased abundance of Glutamic acid (100%), Asparagine (67%), Serine (300%) and Valine (85.7%) in comparison with HCoV-NL-63 (2003). We observed lower GC content in the SARS-CoV-2 (2019) among SARS-CoV (2003) and MERS-CoV (2013). The present findings have evolutionary significance and indicate SARS-CoV-2 (2019) adaptation in human. |
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| ISSN: | 0973-7510 2581-690X |