Human Coronavirus: Envelope Protein Evolution
Envelope protein of human coronavirus play significant role in an evolution and mutation of the virus life cycle. In the present research, the author evaluated amino acid sequences, its abundance and GC content of the genes that corresponds to envelope proteins’ of the human coronaviruses, identifie...
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| Format: | Article |
| Language: | English |
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Journal of Pure and Applied Microbiology
2021-06-01
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| Series: | Journal of Pure and Applied Microbiology |
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| Online Access: | https://microbiologyjournal.org/human-coronavirus-envelope-protein-evolution/ |
| _version_ | 1819138002159403008 |
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| author | Rutuja Ankulkar |
| author_facet | Rutuja Ankulkar |
| author_sort | Rutuja Ankulkar |
| collection | DOAJ |
| description | Envelope protein of human coronavirus play significant role in an evolution and mutation of the virus life cycle. In the present research, the author evaluated amino acid sequences, its abundance and GC content of the genes that corresponds to envelope proteins’ of the human coronaviruses, identified from year 2003-2019. It includes SARS-CoV (2003), HCoV-NL-63 (2003), HCoV-HKU-1 (2004), MERS-CoV (2013), and SARS-CoV-2 (2019). The present research findings illustrated a point mutation in D2 location of SARS-CoV-2 (2019), representing Arginine in the place of Glutamic acid (SARS-CoV, 2003) where glycine was found deleted. SARS-CoV-2 (2019) coronavirus revealed increased abundance of Glutamic acid (100%), Asparagine (67%), Serine (300%) and Valine (85.7%) in comparison with HCoV-NL-63 (2003). We observed lower GC content in the SARS-CoV-2 (2019) among SARS-CoV (2003) and MERS-CoV (2013). The present findings have evolutionary significance and indicate SARS-CoV-2 (2019) adaptation in human. |
| first_indexed | 2024-12-22T10:59:50Z |
| format | Article |
| id | doaj.art-da4b0fe312444ac69b17c8fe6f146fbe |
| institution | Directory Open Access Journal |
| issn | 0973-7510 2581-690X |
| language | English |
| last_indexed | 2024-12-22T10:59:50Z |
| publishDate | 2021-06-01 |
| publisher | Journal of Pure and Applied Microbiology |
| record_format | Article |
| series | Journal of Pure and Applied Microbiology |
| spelling | doaj.art-da4b0fe312444ac69b17c8fe6f146fbe2022-12-21T18:28:33ZengJournal of Pure and Applied MicrobiologyJournal of Pure and Applied Microbiology0973-75102581-690X2021-06-0115259459710.22207/JPAM.15.2.46Human Coronavirus: Envelope Protein EvolutionRutuja Ankulkarhttps://orcid.org/0000-0002-9637-7114Envelope protein of human coronavirus play significant role in an evolution and mutation of the virus life cycle. In the present research, the author evaluated amino acid sequences, its abundance and GC content of the genes that corresponds to envelope proteins’ of the human coronaviruses, identified from year 2003-2019. It includes SARS-CoV (2003), HCoV-NL-63 (2003), HCoV-HKU-1 (2004), MERS-CoV (2013), and SARS-CoV-2 (2019). The present research findings illustrated a point mutation in D2 location of SARS-CoV-2 (2019), representing Arginine in the place of Glutamic acid (SARS-CoV, 2003) where glycine was found deleted. SARS-CoV-2 (2019) coronavirus revealed increased abundance of Glutamic acid (100%), Asparagine (67%), Serine (300%) and Valine (85.7%) in comparison with HCoV-NL-63 (2003). We observed lower GC content in the SARS-CoV-2 (2019) among SARS-CoV (2003) and MERS-CoV (2013). The present findings have evolutionary significance and indicate SARS-CoV-2 (2019) adaptation in human.https://microbiologyjournal.org/human-coronavirus-envelope-protein-evolution/envelope proteincoronavirusessars-cov-2 (2019)genetic evolutiongc contentamino acidsadaptation |
| spellingShingle | Rutuja Ankulkar Human Coronavirus: Envelope Protein Evolution Journal of Pure and Applied Microbiology envelope protein coronaviruses sars-cov-2 (2019) genetic evolution gc content amino acids adaptation |
| title | Human Coronavirus: Envelope Protein Evolution |
| title_full | Human Coronavirus: Envelope Protein Evolution |
| title_fullStr | Human Coronavirus: Envelope Protein Evolution |
| title_full_unstemmed | Human Coronavirus: Envelope Protein Evolution |
| title_short | Human Coronavirus: Envelope Protein Evolution |
| title_sort | human coronavirus envelope protein evolution |
| topic | envelope protein coronaviruses sars-cov-2 (2019) genetic evolution gc content amino acids adaptation |
| url | https://microbiologyjournal.org/human-coronavirus-envelope-protein-evolution/ |
| work_keys_str_mv | AT rutujaankulkar humancoronavirusenvelopeproteinevolution |