Malignant epithelioid hemangioendothelioma of the liver successfully treated with Sorafenib
Epithelioid hemangioendothelioma (HEH) is a rare disease of unknown etiology for which a standard systemic treatment has not been established. The common expression of vascular endothelial growth factor (VEGF) and its receptor in HEH provide a rationale for the reported use of antiangiogenic drugs,...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2012-06-01
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| Series: | Rare Tumors |
| Subjects: | |
| Online Access: | http://www.pagepress.org/journals/index.php/rt/article/view/4046 |
| _version_ | 1828757146645299200 |
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| author | Bruno Sangro Mercedes Iñarrairaegui Nerea Fernández-Ros |
| author_facet | Bruno Sangro Mercedes Iñarrairaegui Nerea Fernández-Ros |
| author_sort | Bruno Sangro |
| collection | DOAJ |
| description | Epithelioid hemangioendothelioma (HEH) is a rare disease of unknown etiology for which a standard systemic treatment has not been established. The common expression of vascular endothelial growth factor (VEGF) and its receptor in HEH provide a rationale for the reported use of antiangiogenic drugs, including bevacizumab, lenalidomide and thalidomide. We report a case of a young male patient with HEH with sorafenib for almost 2 years. Sorafenib was used instead of other VEGF inhibitors due to its convenient oral route, its dual antiangiogenic and antiproliferative activity, and its favorable safety profile. Sorafenib therapy resulted in durable stabilization with progressive calcification of liver tumors and minor but stable response of lung lesions. |
| first_indexed | 2024-12-11T00:21:59Z |
| format | Article |
| id | doaj.art-da4d8739be6a4694a744eadb258c4ae6 |
| institution | Directory Open Access Journal |
| issn | 2036-3605 2036-3613 |
| language | English |
| last_indexed | 2024-12-11T00:21:59Z |
| publishDate | 2012-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Rare Tumors |
| spelling | doaj.art-da4d8739be6a4694a744eadb258c4ae62022-12-22T01:27:42ZengSAGE PublishingRare Tumors2036-36052036-36132012-06-0142e34e3410.4081/rt.2012.e342172Malignant epithelioid hemangioendothelioma of the liver successfully treated with SorafenibBruno Sangro0Mercedes Iñarrairaegui1Nerea Fernández-Ros2Liver Unit, Clínica Universidad de Navarra; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), PamplonaLiver Unit, Clínica Universidad de Navarra; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), PamplonaLiver Unit, Clínica Universidad de Navarra, PamplonaEpithelioid hemangioendothelioma (HEH) is a rare disease of unknown etiology for which a standard systemic treatment has not been established. The common expression of vascular endothelial growth factor (VEGF) and its receptor in HEH provide a rationale for the reported use of antiangiogenic drugs, including bevacizumab, lenalidomide and thalidomide. We report a case of a young male patient with HEH with sorafenib for almost 2 years. Sorafenib was used instead of other VEGF inhibitors due to its convenient oral route, its dual antiangiogenic and antiproliferative activity, and its favorable safety profile. Sorafenib therapy resulted in durable stabilization with progressive calcification of liver tumors and minor but stable response of lung lesions.http://www.pagepress.org/journals/index.php/rt/article/view/4046Hemangioendotheliomasorafenibliver |
| spellingShingle | Bruno Sangro Mercedes Iñarrairaegui Nerea Fernández-Ros Malignant epithelioid hemangioendothelioma of the liver successfully treated with Sorafenib Rare Tumors Hemangioendothelioma sorafenib liver |
| title | Malignant epithelioid hemangioendothelioma of the liver successfully treated with Sorafenib |
| title_full | Malignant epithelioid hemangioendothelioma of the liver successfully treated with Sorafenib |
| title_fullStr | Malignant epithelioid hemangioendothelioma of the liver successfully treated with Sorafenib |
| title_full_unstemmed | Malignant epithelioid hemangioendothelioma of the liver successfully treated with Sorafenib |
| title_short | Malignant epithelioid hemangioendothelioma of the liver successfully treated with Sorafenib |
| title_sort | malignant epithelioid hemangioendothelioma of the liver successfully treated with sorafenib |
| topic | Hemangioendothelioma sorafenib liver |
| url | http://www.pagepress.org/journals/index.php/rt/article/view/4046 |
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