MOTS-c repairs myocardial damage by inhibiting the CCN1/ERK1/2/EGR1 pathway in diabetic rats

MOTS-c repairs myocardial damage by inhibiting the CCN1/ERK1/2/EGR1 pathway in diabetic rats

Cardiac structure remodeling and dysfunction are common complications of diabetes, often leading to serious cardiovascular events. MOTS-c, a mitochondria-derived peptide, regulates metabolic homeostasis by accelerating glucose uptake and improving insulin sensitivity. Plasma levels of MOTS-c are dec...

Full description

Bibliographic Details
Main Authors: Manda Wang, Gangqiang Wang, Xiaoli Pang, Jiacheng Ma, Jinghan Yuan, Yanrong Pan, Yu Fu, Ismail Laher, Shunchang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Nutrition
Subjects:
MOTS-c
type 2 diabetes
mitochondrial
myocardium
transcriptome
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2022.1060684/full

Internet

https://www.frontiersin.org/articles/10.3389/fnut.2022.1060684/full

Similar Items