Validation of a novel method of ultraviolet-induced cutaneous inflammation and its associations with anhedonia
Abstract Affective immunology of the skin is a growing area; however, established protocols for measuring individual differences in cutaneous inflammation are lacking. To address this, we present a preliminary validation of Precision Implementation of Minimal Erythema Dose (PI-MED) testing as a meth...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-24598-4 |
| _version_ | 1811187036365783040 |
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| author | Holly Sullivan-Toole Shengchuang Feng Corinne N. Carlton Merage Ghane Thomas M. Olino Irving C. Allen John A. Richey |
| author_facet | Holly Sullivan-Toole Shengchuang Feng Corinne N. Carlton Merage Ghane Thomas M. Olino Irving C. Allen John A. Richey |
| author_sort | Holly Sullivan-Toole |
| collection | DOAJ |
| description | Abstract Affective immunology of the skin is a growing area; however, established protocols for measuring individual differences in cutaneous inflammation are lacking. To address this, we present a preliminary validation of Precision Implementation of Minimal Erythema Dose (PI-MED) testing as a method for measuring cutaneous inflammation. PI-MED is a recently adapted protocol, optimized for reproducibility and individual differences research, that uses ultraviolet (UV) light to evoke cutaneous erythema, or inflammatory skin reddening. PI-MED’s novel UV dosage schedule produces standardized erythema responses across different skin pigmentation types and shows strong internal consistency within person and good test–retest reliability across 8–10 weeks. In line with predictions, increased PI-MED erythema was associated with heightened anhedonia, across several measures, beyond influences of non-affective covariates. While future work should further refine the dosage schedule for the lightest and darkest skin types, overall, evidence supports PI-MED as a protocol for inducing and measuring individual differences in cutaneous inflammation. Further, PI-MED-induced erythema can expand psychoneuroimmunology research by offering a complementary assessment for general inflammatory tone. This work adds to a growing body of evidence demonstrating a distinct relationship between inflammation and anhedonia. |
| first_indexed | 2024-04-11T13:56:25Z |
| format | Article |
| id | doaj.art-da517c33ff75405295bd1a077ff874b5 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T13:56:25Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-da517c33ff75405295bd1a077ff874b52022-12-22T04:20:20ZengNature PortfolioScientific Reports2045-23222022-11-0112111610.1038/s41598-022-24598-4Validation of a novel method of ultraviolet-induced cutaneous inflammation and its associations with anhedoniaHolly Sullivan-Toole0Shengchuang Feng1Corinne N. Carlton2Merage Ghane3Thomas M. Olino4Irving C. Allen5John A. Richey6Department of Psychology, Virginia TechFralin Biomedical Research Institute at VTCDepartment of Psychology, Virginia TechDepartment of Psychiatry, University of PittsburgDepartment of Psychology and Neuroscience, Temple UniversityDepartment of Biomedical Sciences and PathobiologyDepartment of Psychology, Virginia TechAbstract Affective immunology of the skin is a growing area; however, established protocols for measuring individual differences in cutaneous inflammation are lacking. To address this, we present a preliminary validation of Precision Implementation of Minimal Erythema Dose (PI-MED) testing as a method for measuring cutaneous inflammation. PI-MED is a recently adapted protocol, optimized for reproducibility and individual differences research, that uses ultraviolet (UV) light to evoke cutaneous erythema, or inflammatory skin reddening. PI-MED’s novel UV dosage schedule produces standardized erythema responses across different skin pigmentation types and shows strong internal consistency within person and good test–retest reliability across 8–10 weeks. In line with predictions, increased PI-MED erythema was associated with heightened anhedonia, across several measures, beyond influences of non-affective covariates. While future work should further refine the dosage schedule for the lightest and darkest skin types, overall, evidence supports PI-MED as a protocol for inducing and measuring individual differences in cutaneous inflammation. Further, PI-MED-induced erythema can expand psychoneuroimmunology research by offering a complementary assessment for general inflammatory tone. This work adds to a growing body of evidence demonstrating a distinct relationship between inflammation and anhedonia.https://doi.org/10.1038/s41598-022-24598-4 |
| spellingShingle | Holly Sullivan-Toole Shengchuang Feng Corinne N. Carlton Merage Ghane Thomas M. Olino Irving C. Allen John A. Richey Validation of a novel method of ultraviolet-induced cutaneous inflammation and its associations with anhedonia Scientific Reports |
| title | Validation of a novel method of ultraviolet-induced cutaneous inflammation and its associations with anhedonia |
| title_full | Validation of a novel method of ultraviolet-induced cutaneous inflammation and its associations with anhedonia |
| title_fullStr | Validation of a novel method of ultraviolet-induced cutaneous inflammation and its associations with anhedonia |
| title_full_unstemmed | Validation of a novel method of ultraviolet-induced cutaneous inflammation and its associations with anhedonia |
| title_short | Validation of a novel method of ultraviolet-induced cutaneous inflammation and its associations with anhedonia |
| title_sort | validation of a novel method of ultraviolet induced cutaneous inflammation and its associations with anhedonia |
| url | https://doi.org/10.1038/s41598-022-24598-4 |
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