Ketogenic diets and Ketone suplementation: A strategy for therapeutic intervention
Ketogenic diets and orally administered exogenous ketone supplements are strategies to increase serum ketone bodies serving as an alternative energy fuel for high energy demanding tissues, such as the brain, muscles, and the heart. The ketogenic diet is a low-carbohydrate and fat-rich diet, whereas...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
|
| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.947567/full |
| _version_ | 1828129967020441600 |
|---|---|
| author | Christiaan G. J. Saris Christiaan G. J. Saris Silvie Timmers |
| author_facet | Christiaan G. J. Saris Christiaan G. J. Saris Silvie Timmers |
| author_sort | Christiaan G. J. Saris |
| collection | DOAJ |
| description | Ketogenic diets and orally administered exogenous ketone supplements are strategies to increase serum ketone bodies serving as an alternative energy fuel for high energy demanding tissues, such as the brain, muscles, and the heart. The ketogenic diet is a low-carbohydrate and fat-rich diet, whereas ketone supplements are usually supplied as esters or salts. Nutritional ketosis, defined as serum ketone concentrations of ≥ 0.5 mmol/L, has a fasting-like effect and results in all sorts of metabolic shifts and thereby enhancing the health status. In this review, we thus discuss the different interventions to reach nutritional ketosis, and summarize the effects on heart diseases, epilepsy, mitochondrial diseases, and neurodegenerative disorders. Interest in the proposed therapeutic benefits of nutritional ketosis has been growing the past recent years. The implication of this nutritional intervention is becoming more evident and has shown interesting potential. Mechanistic insights explaining the overall health effects of the ketogenic state, will lead to precision nutrition for the latter diseases. |
| first_indexed | 2024-04-11T16:27:25Z |
| format | Article |
| id | doaj.art-da5366d1f1fc432eb029c3f4d6d2f31a |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-11T16:27:25Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-da5366d1f1fc432eb029c3f4d6d2f31a2022-12-22T04:14:08ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-11-01910.3389/fnut.2022.947567947567Ketogenic diets and Ketone suplementation: A strategy for therapeutic interventionChristiaan G. J. Saris0Christiaan G. J. Saris1Silvie Timmers2Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, NetherlandsRadboud Center for Mitochondrial Medicine, Nijmegen, NetherlandsDepartment of Human and Animal Physiology, Wageningen University, Wageningen, NetherlandsKetogenic diets and orally administered exogenous ketone supplements are strategies to increase serum ketone bodies serving as an alternative energy fuel for high energy demanding tissues, such as the brain, muscles, and the heart. The ketogenic diet is a low-carbohydrate and fat-rich diet, whereas ketone supplements are usually supplied as esters or salts. Nutritional ketosis, defined as serum ketone concentrations of ≥ 0.5 mmol/L, has a fasting-like effect and results in all sorts of metabolic shifts and thereby enhancing the health status. In this review, we thus discuss the different interventions to reach nutritional ketosis, and summarize the effects on heart diseases, epilepsy, mitochondrial diseases, and neurodegenerative disorders. Interest in the proposed therapeutic benefits of nutritional ketosis has been growing the past recent years. The implication of this nutritional intervention is becoming more evident and has shown interesting potential. Mechanistic insights explaining the overall health effects of the ketogenic state, will lead to precision nutrition for the latter diseases.https://www.frontiersin.org/articles/10.3389/fnut.2022.947567/fullnutritional ketosisketogenic dietketone bodiesprecision nutritionketone supplementation |
| spellingShingle | Christiaan G. J. Saris Christiaan G. J. Saris Silvie Timmers Ketogenic diets and Ketone suplementation: A strategy for therapeutic intervention Frontiers in Nutrition nutritional ketosis ketogenic diet ketone bodies precision nutrition ketone supplementation |
| title | Ketogenic diets and Ketone suplementation: A strategy for therapeutic intervention |
| title_full | Ketogenic diets and Ketone suplementation: A strategy for therapeutic intervention |
| title_fullStr | Ketogenic diets and Ketone suplementation: A strategy for therapeutic intervention |
| title_full_unstemmed | Ketogenic diets and Ketone suplementation: A strategy for therapeutic intervention |
| title_short | Ketogenic diets and Ketone suplementation: A strategy for therapeutic intervention |
| title_sort | ketogenic diets and ketone suplementation a strategy for therapeutic intervention |
| topic | nutritional ketosis ketogenic diet ketone bodies precision nutrition ketone supplementation |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.947567/full |
| work_keys_str_mv | AT christiaangjsaris ketogenicdietsandketonesuplementationastrategyfortherapeuticintervention AT christiaangjsaris ketogenicdietsandketonesuplementationastrategyfortherapeuticintervention AT silvietimmers ketogenicdietsandketonesuplementationastrategyfortherapeuticintervention |