Low urinary sodium-to-potassium ratio in the early phase following single-unit cord blood transplantation is a predictive factor for poor non-relapse mortality in adults
Abstract Although daily higher urinary sodium (Na) and potassium (K) excretion ratio is associated with the risk of cardiovascular disease in the general population, a low Na/K ratio is associated with renal dysfunction in critically ill patients. Thus, we retrospectively analyzed the impact of dail...
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| Format: | Article |
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Nature Portfolio
2024-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-51748-7 |
| _version_ | 1797350024861974528 |
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| author | Kosuke Takano Maki Monna-Oiwa Masamichi Isobe Seiko Kato Satoshi Takahashi Yasuhito Nannya Takaaki Konuma |
| author_facet | Kosuke Takano Maki Monna-Oiwa Masamichi Isobe Seiko Kato Satoshi Takahashi Yasuhito Nannya Takaaki Konuma |
| author_sort | Kosuke Takano |
| collection | DOAJ |
| description | Abstract Although daily higher urinary sodium (Na) and potassium (K) excretion ratio is associated with the risk of cardiovascular disease in the general population, a low Na/K ratio is associated with renal dysfunction in critically ill patients. Thus, we retrospectively analyzed the impact of daily urinary Na and K excretion and their ratio on non-relapse mortality (NRM) and overall mortality in 172 adult single-unit cord blood transplantation (CBT) patients treated at our institution between 2007 and 2020. Multivariate analysis showed that a low urinary Na/K ratio at both 14 days (hazard ratio [HR], 4.82; 95% confidence interval [CI], 1.81–12.83; P = 0.001) and 28 days (HR, 4.47; 95% CI 1.32–15.12; P = 0.015) was significantly associated with higher NRM. Furthermore, a low urinary Na/K ratio at 28 days was significantly associated with higher overall mortality (HR, 2.38; 95% CI 1.15–4.91; P = 0.018). Patients with a low urinary Na/K ratio had decreased urine volume, more weight gain, experienced more grade III–IV acute graft-versus-host disease, and required corticosteroids by 28 days after CBT. These findings indicate that a low urinary Na/K ratio early after single-unit CBT is associated with poor NRM and survival in adults. |
| first_indexed | 2024-03-08T12:38:49Z |
| format | Article |
| id | doaj.art-da579cdb9f1e4104aedc02d4cf039936 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T12:38:49Z |
| publishDate | 2024-01-01 |
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| series | Scientific Reports |
| spelling | doaj.art-da579cdb9f1e4104aedc02d4cf0399362024-01-21T12:17:35ZengNature PortfolioScientific Reports2045-23222024-01-0114111110.1038/s41598-024-51748-7Low urinary sodium-to-potassium ratio in the early phase following single-unit cord blood transplantation is a predictive factor for poor non-relapse mortality in adultsKosuke Takano0Maki Monna-Oiwa1Masamichi Isobe2Seiko Kato3Satoshi Takahashi4Yasuhito Nannya5Takaaki Konuma6Department of Hematology/Oncology, The Institute of Medical Science, The University of TokyoDepartment of Hematology/Oncology, The Institute of Medical Science, The University of TokyoDepartment of Hematology/Oncology, The Institute of Medical Science, The University of TokyoDivision of Clinical Precision Research Platform, The Institute of Medical Science, The University of TokyoDivision of Clinical Precision Research Platform, The Institute of Medical Science, The University of TokyoDepartment of Hematology/Oncology, The Institute of Medical Science, The University of TokyoDepartment of Hematology/Oncology, The Institute of Medical Science, The University of TokyoAbstract Although daily higher urinary sodium (Na) and potassium (K) excretion ratio is associated with the risk of cardiovascular disease in the general population, a low Na/K ratio is associated with renal dysfunction in critically ill patients. Thus, we retrospectively analyzed the impact of daily urinary Na and K excretion and their ratio on non-relapse mortality (NRM) and overall mortality in 172 adult single-unit cord blood transplantation (CBT) patients treated at our institution between 2007 and 2020. Multivariate analysis showed that a low urinary Na/K ratio at both 14 days (hazard ratio [HR], 4.82; 95% confidence interval [CI], 1.81–12.83; P = 0.001) and 28 days (HR, 4.47; 95% CI 1.32–15.12; P = 0.015) was significantly associated with higher NRM. Furthermore, a low urinary Na/K ratio at 28 days was significantly associated with higher overall mortality (HR, 2.38; 95% CI 1.15–4.91; P = 0.018). Patients with a low urinary Na/K ratio had decreased urine volume, more weight gain, experienced more grade III–IV acute graft-versus-host disease, and required corticosteroids by 28 days after CBT. These findings indicate that a low urinary Na/K ratio early after single-unit CBT is associated with poor NRM and survival in adults.https://doi.org/10.1038/s41598-024-51748-7 |
| spellingShingle | Kosuke Takano Maki Monna-Oiwa Masamichi Isobe Seiko Kato Satoshi Takahashi Yasuhito Nannya Takaaki Konuma Low urinary sodium-to-potassium ratio in the early phase following single-unit cord blood transplantation is a predictive factor for poor non-relapse mortality in adults Scientific Reports |
| title | Low urinary sodium-to-potassium ratio in the early phase following single-unit cord blood transplantation is a predictive factor for poor non-relapse mortality in adults |
| title_full | Low urinary sodium-to-potassium ratio in the early phase following single-unit cord blood transplantation is a predictive factor for poor non-relapse mortality in adults |
| title_fullStr | Low urinary sodium-to-potassium ratio in the early phase following single-unit cord blood transplantation is a predictive factor for poor non-relapse mortality in adults |
| title_full_unstemmed | Low urinary sodium-to-potassium ratio in the early phase following single-unit cord blood transplantation is a predictive factor for poor non-relapse mortality in adults |
| title_short | Low urinary sodium-to-potassium ratio in the early phase following single-unit cord blood transplantation is a predictive factor for poor non-relapse mortality in adults |
| title_sort | low urinary sodium to potassium ratio in the early phase following single unit cord blood transplantation is a predictive factor for poor non relapse mortality in adults |
| url | https://doi.org/10.1038/s41598-024-51748-7 |
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