Brain nuclear receptors and cardiovascular function
Abstract Brain–heart interaction has raised up increasing attentions. Nuclear receptors (NRs) are abundantly expressed in the brain, and emerging evidence indicates that a number of these brain NRs regulate multiple aspects of cardiovascular diseases (CVDs), including hypertension, heart failure, at...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | Cell & Bioscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13578-023-00962-3 |
| _version_ | 1797945703280934912 |
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| author | Mengjie Wang Yongjie Yang Yong Xu |
| author_facet | Mengjie Wang Yongjie Yang Yong Xu |
| author_sort | Mengjie Wang |
| collection | DOAJ |
| description | Abstract Brain–heart interaction has raised up increasing attentions. Nuclear receptors (NRs) are abundantly expressed in the brain, and emerging evidence indicates that a number of these brain NRs regulate multiple aspects of cardiovascular diseases (CVDs), including hypertension, heart failure, atherosclerosis, etc. In this review, we will elaborate recent findings that have established the physiological relevance of brain NRs in the context of cardiovascular function. In addition, we will discuss the currently available evidence regarding the distinct neuronal populations that respond to brain NRs in the cardiovascular control. These findings suggest connections between cardiac control and brain dynamics through NR signaling, which may lead to novel tools for the treatment of pathological changes in the CVDs. |
| first_indexed | 2024-04-10T21:00:25Z |
| format | Article |
| id | doaj.art-da58267dfdf84c529dd326fbb32f417f |
| institution | Directory Open Access Journal |
| issn | 2045-3701 |
| language | English |
| last_indexed | 2024-04-10T21:00:25Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell & Bioscience |
| spelling | doaj.art-da58267dfdf84c529dd326fbb32f417f2023-01-22T12:26:15ZengBMCCell & Bioscience2045-37012023-01-0113112410.1186/s13578-023-00962-3Brain nuclear receptors and cardiovascular functionMengjie Wang0Yongjie Yang1Yong Xu2Department of Pediatrics, USDA/ARS Children’s Nutrition Research Center, Baylor College of MedicineDepartment of Pediatrics, USDA/ARS Children’s Nutrition Research Center, Baylor College of MedicineDepartment of Pediatrics, USDA/ARS Children’s Nutrition Research Center, Baylor College of MedicineAbstract Brain–heart interaction has raised up increasing attentions. Nuclear receptors (NRs) are abundantly expressed in the brain, and emerging evidence indicates that a number of these brain NRs regulate multiple aspects of cardiovascular diseases (CVDs), including hypertension, heart failure, atherosclerosis, etc. In this review, we will elaborate recent findings that have established the physiological relevance of brain NRs in the context of cardiovascular function. In addition, we will discuss the currently available evidence regarding the distinct neuronal populations that respond to brain NRs in the cardiovascular control. These findings suggest connections between cardiac control and brain dynamics through NR signaling, which may lead to novel tools for the treatment of pathological changes in the CVDs.https://doi.org/10.1186/s13578-023-00962-3Nuclear receptorCentral nervous systemCardiovascular functionBrain–heart interaction |
| spellingShingle | Mengjie Wang Yongjie Yang Yong Xu Brain nuclear receptors and cardiovascular function Cell & Bioscience Nuclear receptor Central nervous system Cardiovascular function Brain–heart interaction |
| title | Brain nuclear receptors and cardiovascular function |
| title_full | Brain nuclear receptors and cardiovascular function |
| title_fullStr | Brain nuclear receptors and cardiovascular function |
| title_full_unstemmed | Brain nuclear receptors and cardiovascular function |
| title_short | Brain nuclear receptors and cardiovascular function |
| title_sort | brain nuclear receptors and cardiovascular function |
| topic | Nuclear receptor Central nervous system Cardiovascular function Brain–heart interaction |
| url | https://doi.org/10.1186/s13578-023-00962-3 |
| work_keys_str_mv | AT mengjiewang brainnuclearreceptorsandcardiovascularfunction AT yongjieyang brainnuclearreceptorsandcardiovascularfunction AT yongxu brainnuclearreceptorsandcardiovascularfunction |