Synbiotics for prevention of ventilator-associated pneumonia: a probiotics strain-specific network meta-analysis
Objective Probiotics may be efficacious in preventing ventilator-associated pneumonia (VAP). The aim of this network meta-analysis (NMA) was to clarify the efficacy of different types of probiotics for preventing VAP. Methods This systematic review and NMA was conducted according to the updated pref...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2019-11-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/0300060519876753 |
| _version_ | 1831706482173804544 |
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| author | Qiong-Li Fan Xiu-Mei Yu Quan-Xing Liu Wang Yang Qin Chang Yu-Ping Zhang |
| author_facet | Qiong-Li Fan Xiu-Mei Yu Quan-Xing Liu Wang Yang Qin Chang Yu-Ping Zhang |
| author_sort | Qiong-Li Fan |
| collection | DOAJ |
| description | Objective Probiotics may be efficacious in preventing ventilator-associated pneumonia (VAP). The aim of this network meta-analysis (NMA) was to clarify the efficacy of different types of probiotics for preventing VAP. Methods This systematic review and NMA was conducted according to the updated preferred reporting items for systematic review and meta-analysis. A systematic literature search of public databases from inception to 17 June 2018 was performed. Results NMA showed that “ Bifidobacterium longum + Lactobacillus bulgaricus + Streptococcus thermophiles ” was more efficacious than “ Ergyphilus ” in preventing VAP (odds ratio: 0.15, 95% confidence interval: 0.03–0.94). According to pairwise meta-analysis, “ B. longum + L. bulgaricus + S. thermophiles ” and “ Lactobacillus rhamnosus ” were superior to placebo in preventing VAP. Treatment rank based on surface under the cumulative ranking curves revealed that the most efficacious treatment for preventing VAP was “ B. longum + L. bulgaricus + S. thermophiles ” (66%). In terms of reducing hospital mortality and ICU mortality, the most efficacious treatment was Synbiotic 2000FORTE (34% and 46%, respectively). Conclusions Based on efficacy ranking, “ B. longum + L. bulgaricus + S. thermophiles ” should be the first choice for prevention of VAP, while Synbiotic 2000FORTE has the potential to reduce in-hospital mortality and ICU mortality. |
| first_indexed | 2024-12-20T16:40:10Z |
| format | Article |
| id | doaj.art-da59788c126745d695947f35e7faedaf |
| institution | Directory Open Access Journal |
| issn | 0300-0605 1473-2300 |
| language | English |
| last_indexed | 2024-12-20T16:40:10Z |
| publishDate | 2019-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-da59788c126745d695947f35e7faedaf2022-12-21T19:33:03ZengSAGE PublishingJournal of International Medical Research0300-06051473-23002019-11-014710.1177/0300060519876753Synbiotics for prevention of ventilator-associated pneumonia: a probiotics strain-specific network meta-analysisQiong-Li FanXiu-Mei YuQuan-Xing LiuWang YangQin ChangYu-Ping ZhangObjective Probiotics may be efficacious in preventing ventilator-associated pneumonia (VAP). The aim of this network meta-analysis (NMA) was to clarify the efficacy of different types of probiotics for preventing VAP. Methods This systematic review and NMA was conducted according to the updated preferred reporting items for systematic review and meta-analysis. A systematic literature search of public databases from inception to 17 June 2018 was performed. Results NMA showed that “ Bifidobacterium longum + Lactobacillus bulgaricus + Streptococcus thermophiles ” was more efficacious than “ Ergyphilus ” in preventing VAP (odds ratio: 0.15, 95% confidence interval: 0.03–0.94). According to pairwise meta-analysis, “ B. longum + L. bulgaricus + S. thermophiles ” and “ Lactobacillus rhamnosus ” were superior to placebo in preventing VAP. Treatment rank based on surface under the cumulative ranking curves revealed that the most efficacious treatment for preventing VAP was “ B. longum + L. bulgaricus + S. thermophiles ” (66%). In terms of reducing hospital mortality and ICU mortality, the most efficacious treatment was Synbiotic 2000FORTE (34% and 46%, respectively). Conclusions Based on efficacy ranking, “ B. longum + L. bulgaricus + S. thermophiles ” should be the first choice for prevention of VAP, while Synbiotic 2000FORTE has the potential to reduce in-hospital mortality and ICU mortality.https://doi.org/10.1177/0300060519876753 |
| spellingShingle | Qiong-Li Fan Xiu-Mei Yu Quan-Xing Liu Wang Yang Qin Chang Yu-Ping Zhang Synbiotics for prevention of ventilator-associated pneumonia: a probiotics strain-specific network meta-analysis Journal of International Medical Research |
| title | Synbiotics for prevention of ventilator-associated pneumonia: a probiotics strain-specific network meta-analysis |
| title_full | Synbiotics for prevention of ventilator-associated pneumonia: a probiotics strain-specific network meta-analysis |
| title_fullStr | Synbiotics for prevention of ventilator-associated pneumonia: a probiotics strain-specific network meta-analysis |
| title_full_unstemmed | Synbiotics for prevention of ventilator-associated pneumonia: a probiotics strain-specific network meta-analysis |
| title_short | Synbiotics for prevention of ventilator-associated pneumonia: a probiotics strain-specific network meta-analysis |
| title_sort | synbiotics for prevention of ventilator associated pneumonia a probiotics strain specific network meta analysis |
| url | https://doi.org/10.1177/0300060519876753 |
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