Newly developed 3D in vitro models to study tumor–immune interaction
Abstract Immunotherapy as a rapidly developing therapeutic approach has revolutionized cancer treatment and revitalized the field of tumor immunology research. 3D in vitro models are emerging as powerful tools considering their feature to maintain tumor cells in a near-native state and have been wid...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-04-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13046-023-02653-w |
| _version_ | 1797849864380350464 |
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| author | Peiyuan Mu Shujuan Zhou Tao Lv Fan Xia Lijun Shen Juefeng Wan Yaqi Wang Hui Zhang Sanjun Cai Junjie Peng Guoqiang Hua Zhen Zhang |
| author_facet | Peiyuan Mu Shujuan Zhou Tao Lv Fan Xia Lijun Shen Juefeng Wan Yaqi Wang Hui Zhang Sanjun Cai Junjie Peng Guoqiang Hua Zhen Zhang |
| author_sort | Peiyuan Mu |
| collection | DOAJ |
| description | Abstract Immunotherapy as a rapidly developing therapeutic approach has revolutionized cancer treatment and revitalized the field of tumor immunology research. 3D in vitro models are emerging as powerful tools considering their feature to maintain tumor cells in a near-native state and have been widely applied in oncology research. The novel 3D culture methods including the co-culture of organoids and immune cells, ALI culture, 3D-microfluidic culture and 3D-bioprinting offer new approaches for tumor immunology study and can be applied in many fields such as personalized treatment, immunotherapy optimizing and adoptive cell therapy. In this review, we introduce commonly used 3D in vitro models and summarize their applications in different aspects of tumor immunology research. We also provide a preliminary analysis of the current shortcomings of these models and the outlook of future development. |
| first_indexed | 2024-04-09T18:51:05Z |
| format | Article |
| id | doaj.art-da59ef95fc0346558ab56ab5b21d6621 |
| institution | Directory Open Access Journal |
| issn | 1756-9966 |
| language | English |
| last_indexed | 2024-04-09T18:51:05Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj.art-da59ef95fc0346558ab56ab5b21d66212023-04-09T11:29:55ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662023-04-0142111610.1186/s13046-023-02653-wNewly developed 3D in vitro models to study tumor–immune interactionPeiyuan Mu0Shujuan Zhou1Tao Lv2Fan Xia3Lijun Shen4Juefeng Wan5Yaqi Wang6Hui Zhang7Sanjun Cai8Junjie Peng9Guoqiang Hua10Zhen Zhang11Department of Radiation Oncology, Fudan University Shanghai Cancer CenterDepartment of Radiation Oncology, Fudan University Shanghai Cancer CenterDepartment of Radiation Oncology, Fudan University Shanghai Cancer CenterDepartment of Radiation Oncology, Fudan University Shanghai Cancer CenterDepartment of Radiation Oncology, Fudan University Shanghai Cancer CenterDepartment of Radiation Oncology, Fudan University Shanghai Cancer CenterDepartment of Radiation Oncology, Fudan University Shanghai Cancer CenterDepartment of Radiation Oncology, Fudan University Shanghai Cancer CenterDepartment of Oncology, Shanghai Medical College, Fudan UniversityDepartment of Oncology, Shanghai Medical College, Fudan UniversityDepartment of Radiation Oncology, Fudan University Shanghai Cancer CenterDepartment of Radiation Oncology, Fudan University Shanghai Cancer CenterAbstract Immunotherapy as a rapidly developing therapeutic approach has revolutionized cancer treatment and revitalized the field of tumor immunology research. 3D in vitro models are emerging as powerful tools considering their feature to maintain tumor cells in a near-native state and have been widely applied in oncology research. The novel 3D culture methods including the co-culture of organoids and immune cells, ALI culture, 3D-microfluidic culture and 3D-bioprinting offer new approaches for tumor immunology study and can be applied in many fields such as personalized treatment, immunotherapy optimizing and adoptive cell therapy. In this review, we introduce commonly used 3D in vitro models and summarize their applications in different aspects of tumor immunology research. We also provide a preliminary analysis of the current shortcomings of these models and the outlook of future development.https://doi.org/10.1186/s13046-023-02653-w3D modelOrganoidTumor microenvironmentImmunotherapy |
| spellingShingle | Peiyuan Mu Shujuan Zhou Tao Lv Fan Xia Lijun Shen Juefeng Wan Yaqi Wang Hui Zhang Sanjun Cai Junjie Peng Guoqiang Hua Zhen Zhang Newly developed 3D in vitro models to study tumor–immune interaction Journal of Experimental & Clinical Cancer Research 3D model Organoid Tumor microenvironment Immunotherapy |
| title | Newly developed 3D in vitro models to study tumor–immune interaction |
| title_full | Newly developed 3D in vitro models to study tumor–immune interaction |
| title_fullStr | Newly developed 3D in vitro models to study tumor–immune interaction |
| title_full_unstemmed | Newly developed 3D in vitro models to study tumor–immune interaction |
| title_short | Newly developed 3D in vitro models to study tumor–immune interaction |
| title_sort | newly developed 3d in vitro models to study tumor immune interaction |
| topic | 3D model Organoid Tumor microenvironment Immunotherapy |
| url | https://doi.org/10.1186/s13046-023-02653-w |
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