Oral erythromycin for treatment of gastrointestinal dysmotility in premature infants
Background Functional immaturity of gastrointestinal (GI) motility predisposes preterm infants to feeding intolerance. Erythromycin as a prokinetic agent has been given to preterm infants for the management of non-obstructive GI dysmotility. Objective To evaluate the efficacy of oral erythromycin fo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Indonesian Pediatric Society Publishing House
2007-10-01
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| Series: | Paediatrica Indonesiana |
| Subjects: | |
| Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/421 |
| _version_ | 1818519562796138496 |
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| author | Armelia Moesri Bugis Mardina Lubis Asrul Asrul Atan Baas Sinuhaji Guslihan Dasa Tjipta |
| author_facet | Armelia Moesri Bugis Mardina Lubis Asrul Asrul Atan Baas Sinuhaji Guslihan Dasa Tjipta |
| author_sort | Armelia Moesri |
| collection | DOAJ |
| description | Background Functional immaturity of gastrointestinal (GI)
motility predisposes preterm infants to feeding intolerance.
Erythromycin as a prokinetic agent has been given to preterm
infants for the management of non-obstructive GI dysmotility.
Objective To evaluate the efficacy of oral erythromycin for the
treatment of GI dysmotility in preterm infants.
Methods A randomized controlled clinical trial was done at Adam
Malik Hospital and Pirngadi Hospital, Medan, between October
2004 – March 2005. Fifty preterm infants with feeding intolerance
were randomly assigned to either receive oral erythromycin (12.5
mg/kg, every 6 hours) or placebo for 7 days. Improved tolerance
for enteral feedings was evaluated by the amount of gastric residue
before feeding.
Results On the sixth day, there was a significant difference in the
amount of residue from gastric residue between the oral
erythromycin group and placebo group (mean 21.7 and 29.4;
P<0.05) and so were results on the seventh day (mean 14.1 and
26.9; P<0.05).
Conclusion Oral erythromycin reduces the amount of gastric
residue before feed in premature infants. |
| first_indexed | 2024-12-11T01:25:51Z |
| format | Article |
| id | doaj.art-da5b11d2451d40068e674cd960f721fe |
| institution | Directory Open Access Journal |
| issn | 0030-9311 2338-476X |
| language | English |
| last_indexed | 2024-12-11T01:25:51Z |
| publishDate | 2007-10-01 |
| publisher | Indonesian Pediatric Society Publishing House |
| record_format | Article |
| series | Paediatrica Indonesiana |
| spelling | doaj.art-da5b11d2451d40068e674cd960f721fe2022-12-22T01:25:31ZengIndonesian Pediatric Society Publishing HousePaediatrica Indonesiana0030-93112338-476X2007-10-01475234710.14238/pi47.5.2007.234-7312Oral erythromycin for treatment of gastrointestinal dysmotility in premature infantsArmelia MoesriBugis Mardina LubisAsrul AsrulAtan Baas SinuhajiGuslihan Dasa TjiptaBackground Functional immaturity of gastrointestinal (GI) motility predisposes preterm infants to feeding intolerance. Erythromycin as a prokinetic agent has been given to preterm infants for the management of non-obstructive GI dysmotility. Objective To evaluate the efficacy of oral erythromycin for the treatment of GI dysmotility in preterm infants. Methods A randomized controlled clinical trial was done at Adam Malik Hospital and Pirngadi Hospital, Medan, between October 2004 – March 2005. Fifty preterm infants with feeding intolerance were randomly assigned to either receive oral erythromycin (12.5 mg/kg, every 6 hours) or placebo for 7 days. Improved tolerance for enteral feedings was evaluated by the amount of gastric residue before feeding. Results On the sixth day, there was a significant difference in the amount of residue from gastric residue between the oral erythromycin group and placebo group (mean 21.7 and 29.4; P<0.05) and so were results on the seventh day (mean 14.1 and 26.9; P<0.05). Conclusion Oral erythromycin reduces the amount of gastric residue before feed in premature infants.https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/421erythromycingastrointestinal dysmotilitypreterm infants |
| spellingShingle | Armelia Moesri Bugis Mardina Lubis Asrul Asrul Atan Baas Sinuhaji Guslihan Dasa Tjipta Oral erythromycin for treatment of gastrointestinal dysmotility in premature infants Paediatrica Indonesiana erythromycin gastrointestinal dysmotility preterm infants |
| title | Oral erythromycin for treatment of gastrointestinal dysmotility in premature infants |
| title_full | Oral erythromycin for treatment of gastrointestinal dysmotility in premature infants |
| title_fullStr | Oral erythromycin for treatment of gastrointestinal dysmotility in premature infants |
| title_full_unstemmed | Oral erythromycin for treatment of gastrointestinal dysmotility in premature infants |
| title_short | Oral erythromycin for treatment of gastrointestinal dysmotility in premature infants |
| title_sort | oral erythromycin for treatment of gastrointestinal dysmotility in premature infants |
| topic | erythromycin gastrointestinal dysmotility preterm infants |
| url | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/421 |
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