Effects of a Proton-Pump Inhibitor on Postnasal Drip Symptoms in Patients With Laryngopharyngeal Reflux
Background and Objectives Laryngopharyngeal reflux (LPR) is an increasingly common disease, characterized by stomach acid reflux reaching the upper airways. Postnasal drip (PND) is a known consequence of LPR, defined as mucus accumulation perceived in the posterior areas of the nose and throat. PND...
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| Format: | Article |
| Language: | English |
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Korean Rhinologic Society
2023-11-01
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| Series: | Journal of Rhinology |
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| Online Access: | http://www.j-rhinology.org/upload/pdf/jr-2023-00052.pdf |
| _version_ | 1797311412282851328 |
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| author | Jun Yong Lee Seung Heon Kang Min Jai Cho Hahn Jin Jung |
| author_facet | Jun Yong Lee Seung Heon Kang Min Jai Cho Hahn Jin Jung |
| author_sort | Jun Yong Lee |
| collection | DOAJ |
| description | Background and Objectives Laryngopharyngeal reflux (LPR) is an increasingly common disease, characterized by stomach acid reflux reaching the upper airways. Postnasal drip (PND) is a known consequence of LPR, defined as mucus accumulation perceived in the posterior areas of the nose and throat. PND is among the most common causes of persistent cough, hoarseness, sore throat, and other symptoms, affecting the quality of life. This study aimed to evaluate the effects of a proton-pump inhibitor (PPI) on PND symptoms in patients with LPR. Methods We prospectively enrolled patients diagnosed with LPR at our institution between September 2019 and June 2020. The patients were randomly assigned to either the treatment group (20 mg of ilaprazole daily for 8 weeks) or the control group. The scores for the Reflux Symptom Index (RSI), Reflux Finding Score (RFS), and Sino-Nasal Outcome Test (SNOT)-20 were evaluated at baseline and at the end of treatment, focusing on PND symptoms. Results Eighty patients (28 men and 52 women; mean age, 48.8 years, range, 22–78 years) were enrolled, with 43 in the treatment group and 37 in the control group. The initial RSI, RFS, and SNOT-20 scores were similar between the two groups, and they decreased significantly only in the treatment group (p=0.002, p<0.001, and p=0.015, respectively). However, the PND symptom scores showed a significant decrease in the treatment group only in the RSI (p=0.012). Conclusion PPI treatment for 8 weeks may be effective in improving PND symptoms in patients with LPR. |
| first_indexed | 2024-03-08T01:59:16Z |
| format | Article |
| id | doaj.art-da5d672a5b914b66a4cdadceb64944d4 |
| institution | Directory Open Access Journal |
| issn | 1229-1498 2384-4361 |
| language | English |
| last_indexed | 2024-03-08T01:59:16Z |
| publishDate | 2023-11-01 |
| publisher | Korean Rhinologic Society |
| record_format | Article |
| series | Journal of Rhinology |
| spelling | doaj.art-da5d672a5b914b66a4cdadceb64944d42024-02-14T07:09:37ZengKorean Rhinologic SocietyJournal of Rhinology1229-14982384-43612023-11-0130313914310.18787/jr.2023.00052791Effects of a Proton-Pump Inhibitor on Postnasal Drip Symptoms in Patients With Laryngopharyngeal RefluxJun Yong Lee0Seung Heon Kang1Min Jai Cho2Hahn Jin Jung3 Department of Otorhinolaryngology-Head and Neck Surgery, Chungbuk National University College of Medicine, Chungbuk National University Hospital, Cheongju, Republic of Korea Department of Otorhinolaryngology-Head and Neck Surgery, Chungbuk National University College of Medicine, Chungbuk National University Hospital, Cheongju, Republic of Korea Department of Neurosurgery, Chungbuk National University College of Medicine, Chungbuk National University Hospital, Cheongju, Republic of Korea Department of Otorhinolaryngology-Head and Neck Surgery, Chungbuk National University College of Medicine, Chungbuk National University Hospital, Cheongju, Republic of KoreaBackground and Objectives Laryngopharyngeal reflux (LPR) is an increasingly common disease, characterized by stomach acid reflux reaching the upper airways. Postnasal drip (PND) is a known consequence of LPR, defined as mucus accumulation perceived in the posterior areas of the nose and throat. PND is among the most common causes of persistent cough, hoarseness, sore throat, and other symptoms, affecting the quality of life. This study aimed to evaluate the effects of a proton-pump inhibitor (PPI) on PND symptoms in patients with LPR. Methods We prospectively enrolled patients diagnosed with LPR at our institution between September 2019 and June 2020. The patients were randomly assigned to either the treatment group (20 mg of ilaprazole daily for 8 weeks) or the control group. The scores for the Reflux Symptom Index (RSI), Reflux Finding Score (RFS), and Sino-Nasal Outcome Test (SNOT)-20 were evaluated at baseline and at the end of treatment, focusing on PND symptoms. Results Eighty patients (28 men and 52 women; mean age, 48.8 years, range, 22–78 years) were enrolled, with 43 in the treatment group and 37 in the control group. The initial RSI, RFS, and SNOT-20 scores were similar between the two groups, and they decreased significantly only in the treatment group (p=0.002, p<0.001, and p=0.015, respectively). However, the PND symptom scores showed a significant decrease in the treatment group only in the RSI (p=0.012). Conclusion PPI treatment for 8 weeks may be effective in improving PND symptoms in patients with LPR.http://www.j-rhinology.org/upload/pdf/jr-2023-00052.pdflaryngopharyngeal refluxproton pump inhibitorpostnasal drip |
| spellingShingle | Jun Yong Lee Seung Heon Kang Min Jai Cho Hahn Jin Jung Effects of a Proton-Pump Inhibitor on Postnasal Drip Symptoms in Patients With Laryngopharyngeal Reflux Journal of Rhinology laryngopharyngeal reflux proton pump inhibitor postnasal drip |
| title | Effects of a Proton-Pump Inhibitor on Postnasal Drip Symptoms in Patients With Laryngopharyngeal Reflux |
| title_full | Effects of a Proton-Pump Inhibitor on Postnasal Drip Symptoms in Patients With Laryngopharyngeal Reflux |
| title_fullStr | Effects of a Proton-Pump Inhibitor on Postnasal Drip Symptoms in Patients With Laryngopharyngeal Reflux |
| title_full_unstemmed | Effects of a Proton-Pump Inhibitor on Postnasal Drip Symptoms in Patients With Laryngopharyngeal Reflux |
| title_short | Effects of a Proton-Pump Inhibitor on Postnasal Drip Symptoms in Patients With Laryngopharyngeal Reflux |
| title_sort | effects of a proton pump inhibitor on postnasal drip symptoms in patients with laryngopharyngeal reflux |
| topic | laryngopharyngeal reflux proton pump inhibitor postnasal drip |
| url | http://www.j-rhinology.org/upload/pdf/jr-2023-00052.pdf |
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