Membrane Contact Sites in Yeast: Control Hubs of Sphingolipid Homeostasis
Sphingolipids are the most diverse class of membrane lipids, in terms of their structure and function. Structurally simple sphingolipid precursors, such as ceramides, act as intracellular signaling molecules in various processes, including apoptosis, whereas mature and complex forms of sphingolipids...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Membranes |
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| Online Access: | https://www.mdpi.com/2077-0375/11/12/971 |
| _version_ | 1797502614171025408 |
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| author | Philipp Schlarmann Atsuko Ikeda Kouichi Funato |
| author_facet | Philipp Schlarmann Atsuko Ikeda Kouichi Funato |
| author_sort | Philipp Schlarmann |
| collection | DOAJ |
| description | Sphingolipids are the most diverse class of membrane lipids, in terms of their structure and function. Structurally simple sphingolipid precursors, such as ceramides, act as intracellular signaling molecules in various processes, including apoptosis, whereas mature and complex forms of sphingolipids are important structural components of the plasma membrane. Supplying complex sphingolipids to the plasma membrane, according to need, while keeping pro-apoptotic ceramides in check is an intricate task for the cell and requires mechanisms that tightly control sphingolipid synthesis, breakdown, and storage. As each of these processes takes place in different organelles, recent studies, using the budding yeast <i>Saccharomyces cerevisiae</i>, have investigated the role of membrane contact sites as hubs that integrate inter-organellar sphingolipid transport and regulation. In this review, we provide a detailed overview of the findings of these studies and put them into the context of established regulatory mechanisms of sphingolipid homeostasis. We have focused on the role of membrane contact sites in sphingolipid metabolism and ceramide transport, as well as the mechanisms that prevent toxic ceramide accumulation. |
| first_indexed | 2024-03-10T03:35:37Z |
| format | Article |
| id | doaj.art-da5e5e17ff9446fca30f881203c7f7f3 |
| institution | Directory Open Access Journal |
| issn | 2077-0375 |
| language | English |
| last_indexed | 2024-03-10T03:35:37Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Membranes |
| spelling | doaj.art-da5e5e17ff9446fca30f881203c7f7f32023-11-23T09:30:38ZengMDPI AGMembranes2077-03752021-12-01111297110.3390/membranes11120971Membrane Contact Sites in Yeast: Control Hubs of Sphingolipid HomeostasisPhilipp Schlarmann0Atsuko Ikeda1Kouichi Funato2Graduate School of Integrated Sciences for Life, Hiroshima University, Kagamiyama 1-4-4, Higashi-Hiroshima 739-8528, JapanGraduate School of Integrated Sciences for Life, Hiroshima University, Kagamiyama 1-4-4, Higashi-Hiroshima 739-8528, JapanGraduate School of Integrated Sciences for Life, Hiroshima University, Kagamiyama 1-4-4, Higashi-Hiroshima 739-8528, JapanSphingolipids are the most diverse class of membrane lipids, in terms of their structure and function. Structurally simple sphingolipid precursors, such as ceramides, act as intracellular signaling molecules in various processes, including apoptosis, whereas mature and complex forms of sphingolipids are important structural components of the plasma membrane. Supplying complex sphingolipids to the plasma membrane, according to need, while keeping pro-apoptotic ceramides in check is an intricate task for the cell and requires mechanisms that tightly control sphingolipid synthesis, breakdown, and storage. As each of these processes takes place in different organelles, recent studies, using the budding yeast <i>Saccharomyces cerevisiae</i>, have investigated the role of membrane contact sites as hubs that integrate inter-organellar sphingolipid transport and regulation. In this review, we provide a detailed overview of the findings of these studies and put them into the context of established regulatory mechanisms of sphingolipid homeostasis. We have focused on the role of membrane contact sites in sphingolipid metabolism and ceramide transport, as well as the mechanisms that prevent toxic ceramide accumulation.https://www.mdpi.com/2077-0375/11/12/971sphingolipidsmembrane contact sitesmetabolismceramidesnon-vesicular transportlipotoxicity |
| spellingShingle | Philipp Schlarmann Atsuko Ikeda Kouichi Funato Membrane Contact Sites in Yeast: Control Hubs of Sphingolipid Homeostasis Membranes sphingolipids membrane contact sites metabolism ceramides non-vesicular transport lipotoxicity |
| title | Membrane Contact Sites in Yeast: Control Hubs of Sphingolipid Homeostasis |
| title_full | Membrane Contact Sites in Yeast: Control Hubs of Sphingolipid Homeostasis |
| title_fullStr | Membrane Contact Sites in Yeast: Control Hubs of Sphingolipid Homeostasis |
| title_full_unstemmed | Membrane Contact Sites in Yeast: Control Hubs of Sphingolipid Homeostasis |
| title_short | Membrane Contact Sites in Yeast: Control Hubs of Sphingolipid Homeostasis |
| title_sort | membrane contact sites in yeast control hubs of sphingolipid homeostasis |
| topic | sphingolipids membrane contact sites metabolism ceramides non-vesicular transport lipotoxicity |
| url | https://www.mdpi.com/2077-0375/11/12/971 |
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