Systematic Review: Quantitative Susceptibility Mapping (QSM) of Brain Iron Profile in Neurodegenerative Diseases
Iron has been increasingly implicated in the pathology of neurodegenerative diseases. In the past decade, development of the new magnetic resonance imaging technique, quantitative susceptibility mapping (QSM), has enabled for the more comprehensive investigation of iron distribution in the brain. Th...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-02-01
|
| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2021.618435/full |
| _version_ | 1818330102826532864 |
|---|---|
| author | Parsa Ravanfar Samantha M. Loi Samantha M. Loi Warda T. Syeda Tamsyn E. Van Rheenen Tamsyn E. Van Rheenen Ashley I. Bush Patricia Desmond Patricia Desmond Vanessa L. Cropley Vanessa L. Cropley Darius J. R. Lane Carlos M. Opazo Bradford A. Moffat Bradford A. Moffat Dennis Velakoulis Dennis Velakoulis Christos Pantelis Christos Pantelis |
| author_facet | Parsa Ravanfar Samantha M. Loi Samantha M. Loi Warda T. Syeda Tamsyn E. Van Rheenen Tamsyn E. Van Rheenen Ashley I. Bush Patricia Desmond Patricia Desmond Vanessa L. Cropley Vanessa L. Cropley Darius J. R. Lane Carlos M. Opazo Bradford A. Moffat Bradford A. Moffat Dennis Velakoulis Dennis Velakoulis Christos Pantelis Christos Pantelis |
| author_sort | Parsa Ravanfar |
| collection | DOAJ |
| description | Iron has been increasingly implicated in the pathology of neurodegenerative diseases. In the past decade, development of the new magnetic resonance imaging technique, quantitative susceptibility mapping (QSM), has enabled for the more comprehensive investigation of iron distribution in the brain. The aim of this systematic review was to provide a synthesis of the findings from existing QSM studies in neurodegenerative diseases. We identified 80 records by searching MEDLINE, Embase, Scopus, and PsycInfo databases. The disorders investigated in these studies included Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Wilson's disease, Huntington's disease, Friedreich's ataxia, spinocerebellar ataxia, Fabry disease, myotonic dystrophy, pantothenate-kinase-associated neurodegeneration, and mitochondrial membrane protein-associated neurodegeneration. As a general pattern, QSM revealed increased magnetic susceptibility (suggestive of increased iron content) in the brain regions associated with the pathology of each disorder, such as the amygdala and caudate nucleus in Alzheimer's disease, the substantia nigra in Parkinson's disease, motor cortex in amyotrophic lateral sclerosis, basal ganglia in Huntington's disease, and cerebellar dentate nucleus in Friedreich's ataxia. Furthermore, the increased magnetic susceptibility correlated with disease duration and severity of clinical features in some disorders. Although the number of studies is still limited in most of the neurodegenerative diseases, the existing evidence suggests that QSM can be a promising tool in the investigation of neurodegeneration. |
| first_indexed | 2024-12-13T12:58:37Z |
| format | Article |
| id | doaj.art-da5ed5350e9d4b79bd3d6b806c7b0886 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-13T12:58:37Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-da5ed5350e9d4b79bd3d6b806c7b08862022-12-21T23:45:07ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2021-02-011510.3389/fnins.2021.618435618435Systematic Review: Quantitative Susceptibility Mapping (QSM) of Brain Iron Profile in Neurodegenerative DiseasesParsa Ravanfar0Samantha M. Loi1Samantha M. Loi2Warda T. Syeda3Tamsyn E. Van Rheenen4Tamsyn E. Van Rheenen5Ashley I. Bush6Patricia Desmond7Patricia Desmond8Vanessa L. Cropley9Vanessa L. Cropley10Darius J. R. Lane11Carlos M. Opazo12Bradford A. Moffat13Bradford A. Moffat14Dennis Velakoulis15Dennis Velakoulis16Christos Pantelis17Christos Pantelis18Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, AustraliaMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, AustraliaNeuropsychiatry, The Royal Melbourne Hospital, Parkville, VIC, AustraliaMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, AustraliaMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, AustraliaCentre for Mental Health, Swinburne University of Technology, Hawthorn, VIC, AustraliaMelbourne Dementia Research Centre, Florey Institute of Neuroscience & Mental Health, The University of Melbourne, Parkville, VIC, AustraliaMelbourne Brain Centre Imaging Unit, Department of Medicine and Radiology, The University of Melbourne, Parkville, VIC, AustraliaDepartment of Radiology, The Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC, AustraliaMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, AustraliaCentre for Mental Health, Swinburne University of Technology, Hawthorn, VIC, AustraliaMelbourne Dementia Research Centre, Florey Institute of Neuroscience & Mental Health, The University of Melbourne, Parkville, VIC, AustraliaFlorey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, AustraliaMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, AustraliaMelbourne Brain Centre Imaging Unit, Department of Medicine and Radiology, The University of Melbourne, Parkville, VIC, AustraliaMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, AustraliaNeuropsychiatry, The Royal Melbourne Hospital, Parkville, VIC, AustraliaMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, AustraliaFlorey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, AustraliaIron has been increasingly implicated in the pathology of neurodegenerative diseases. In the past decade, development of the new magnetic resonance imaging technique, quantitative susceptibility mapping (QSM), has enabled for the more comprehensive investigation of iron distribution in the brain. The aim of this systematic review was to provide a synthesis of the findings from existing QSM studies in neurodegenerative diseases. We identified 80 records by searching MEDLINE, Embase, Scopus, and PsycInfo databases. The disorders investigated in these studies included Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Wilson's disease, Huntington's disease, Friedreich's ataxia, spinocerebellar ataxia, Fabry disease, myotonic dystrophy, pantothenate-kinase-associated neurodegeneration, and mitochondrial membrane protein-associated neurodegeneration. As a general pattern, QSM revealed increased magnetic susceptibility (suggestive of increased iron content) in the brain regions associated with the pathology of each disorder, such as the amygdala and caudate nucleus in Alzheimer's disease, the substantia nigra in Parkinson's disease, motor cortex in amyotrophic lateral sclerosis, basal ganglia in Huntington's disease, and cerebellar dentate nucleus in Friedreich's ataxia. Furthermore, the increased magnetic susceptibility correlated with disease duration and severity of clinical features in some disorders. Although the number of studies is still limited in most of the neurodegenerative diseases, the existing evidence suggests that QSM can be a promising tool in the investigation of neurodegeneration.https://www.frontiersin.org/articles/10.3389/fnins.2021.618435/fullquantitative susceptibility mappingbrainironAlzheimer's diseaseParkinson's diseaseneurodegenerative diseases |
| spellingShingle | Parsa Ravanfar Samantha M. Loi Samantha M. Loi Warda T. Syeda Tamsyn E. Van Rheenen Tamsyn E. Van Rheenen Ashley I. Bush Patricia Desmond Patricia Desmond Vanessa L. Cropley Vanessa L. Cropley Darius J. R. Lane Carlos M. Opazo Bradford A. Moffat Bradford A. Moffat Dennis Velakoulis Dennis Velakoulis Christos Pantelis Christos Pantelis Systematic Review: Quantitative Susceptibility Mapping (QSM) of Brain Iron Profile in Neurodegenerative Diseases Frontiers in Neuroscience quantitative susceptibility mapping brain iron Alzheimer's disease Parkinson's disease neurodegenerative diseases |
| title | Systematic Review: Quantitative Susceptibility Mapping (QSM) of Brain Iron Profile in Neurodegenerative Diseases |
| title_full | Systematic Review: Quantitative Susceptibility Mapping (QSM) of Brain Iron Profile in Neurodegenerative Diseases |
| title_fullStr | Systematic Review: Quantitative Susceptibility Mapping (QSM) of Brain Iron Profile in Neurodegenerative Diseases |
| title_full_unstemmed | Systematic Review: Quantitative Susceptibility Mapping (QSM) of Brain Iron Profile in Neurodegenerative Diseases |
| title_short | Systematic Review: Quantitative Susceptibility Mapping (QSM) of Brain Iron Profile in Neurodegenerative Diseases |
| title_sort | systematic review quantitative susceptibility mapping qsm of brain iron profile in neurodegenerative diseases |
| topic | quantitative susceptibility mapping brain iron Alzheimer's disease Parkinson's disease neurodegenerative diseases |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2021.618435/full |
| work_keys_str_mv | AT parsaravanfar systematicreviewquantitativesusceptibilitymappingqsmofbrainironprofileinneurodegenerativediseases AT samanthamloi systematicreviewquantitativesusceptibilitymappingqsmofbrainironprofileinneurodegenerativediseases AT samanthamloi systematicreviewquantitativesusceptibilitymappingqsmofbrainironprofileinneurodegenerativediseases AT wardatsyeda systematicreviewquantitativesusceptibilitymappingqsmofbrainironprofileinneurodegenerativediseases AT tamsynevanrheenen systematicreviewquantitativesusceptibilitymappingqsmofbrainironprofileinneurodegenerativediseases AT tamsynevanrheenen systematicreviewquantitativesusceptibilitymappingqsmofbrainironprofileinneurodegenerativediseases AT ashleyibush systematicreviewquantitativesusceptibilitymappingqsmofbrainironprofileinneurodegenerativediseases AT patriciadesmond systematicreviewquantitativesusceptibilitymappingqsmofbrainironprofileinneurodegenerativediseases AT patriciadesmond systematicreviewquantitativesusceptibilitymappingqsmofbrainironprofileinneurodegenerativediseases AT vanessalcropley systematicreviewquantitativesusceptibilitymappingqsmofbrainironprofileinneurodegenerativediseases AT vanessalcropley systematicreviewquantitativesusceptibilitymappingqsmofbrainironprofileinneurodegenerativediseases AT dariusjrlane systematicreviewquantitativesusceptibilitymappingqsmofbrainironprofileinneurodegenerativediseases AT carlosmopazo systematicreviewquantitativesusceptibilitymappingqsmofbrainironprofileinneurodegenerativediseases AT bradfordamoffat systematicreviewquantitativesusceptibilitymappingqsmofbrainironprofileinneurodegenerativediseases AT bradfordamoffat systematicreviewquantitativesusceptibilitymappingqsmofbrainironprofileinneurodegenerativediseases AT dennisvelakoulis systematicreviewquantitativesusceptibilitymappingqsmofbrainironprofileinneurodegenerativediseases AT dennisvelakoulis systematicreviewquantitativesusceptibilitymappingqsmofbrainironprofileinneurodegenerativediseases AT christospantelis systematicreviewquantitativesusceptibilitymappingqsmofbrainironprofileinneurodegenerativediseases AT christospantelis systematicreviewquantitativesusceptibilitymappingqsmofbrainironprofileinneurodegenerativediseases |