Association between Diabetic Peripheral Neuropathy as Measured Using a Point-of-Care Sural Nerve Conduction Device and Urinary Albumin Excretion in Patients with Type 2 Diabetes
Background: It is not well known whether diabetic peripheral neuropathy diagnosed using a non-invasive point-of-care nerve conduction device called DPN-Check<sup>®</sup> is associated with diabetic nephropathy. Thus, we aimed to evaluate the association of diabetic peripheral neuropathy...
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MDPI AG
2023-06-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/12/4089 |
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| author | Tatsuya Fukuda Akiko Fujii Taro Akihisa Naoya Otsubo Masanori Murakami Tetsuya Yamada Chisato Maki |
| author_facet | Tatsuya Fukuda Akiko Fujii Taro Akihisa Naoya Otsubo Masanori Murakami Tetsuya Yamada Chisato Maki |
| author_sort | Tatsuya Fukuda |
| collection | DOAJ |
| description | Background: It is not well known whether diabetic peripheral neuropathy diagnosed using a non-invasive point-of-care nerve conduction device called DPN-Check<sup>®</sup> is associated with diabetic nephropathy. Thus, we aimed to evaluate the association of diabetic peripheral neuropathy with urinary albumin excretion in patients with type 2 diabetes using DPN-Check<sup>®</sup>. Methods: This retrospective observational study included 323 Japanese patients with type 2 diabetes. The urinary albumin-to-creatinine ratio in a spot urine sample was defined as urinary albumin excretion. Multiple linear regression analysis was used to determine the association of DPN-Check<sup>®</sup>-determined diabetic peripheral neuropathy with urinary albumin excretion. Results: Patients with DPN-Check<sup>®</sup>-determined diabetic peripheral neuropathy had significantly higher urinary albumin excretion than those without, while there was no difference in urinary albumin excretion between patients with and without diabetic peripheral neuropathy determined by simplified diagnostic criteria. In the multivariate model, the DPN-Check<sup>®</sup> determined that diabetic peripheral neuropathy was significantly associated with urinary albumin excretion even after adjustment for covariates (standardized β, 0.123; <i>p</i> = 0.012). Conclusions: Our study found a significant association between diabetic peripheral neuropathy diagnosed using DPN-Check<sup>®</sup> and urinary albumin excretion in patients with type 2 diabetes. |
| first_indexed | 2024-03-11T02:18:51Z |
| format | Article |
| id | doaj.art-da5f1f9927054a55a55be29e62a83617 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T02:18:51Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-da5f1f9927054a55a55be29e62a836172023-11-18T11:00:50ZengMDPI AGJournal of Clinical Medicine2077-03832023-06-011212408910.3390/jcm12124089Association between Diabetic Peripheral Neuropathy as Measured Using a Point-of-Care Sural Nerve Conduction Device and Urinary Albumin Excretion in Patients with Type 2 DiabetesTatsuya Fukuda0Akiko Fujii1Taro Akihisa2Naoya Otsubo3Masanori Murakami4Tetsuya Yamada5Chisato Maki6Department of Endocrinology and Metabolism, Tokyo Metropolitan Okubo Hospital, Tokyo 160-8488, JapanDepartment of Endocrinology and Metabolism, Tokyo Metropolitan Okubo Hospital, Tokyo 160-8488, JapanDepartment of Endocrinology and Metabolism, Tokyo Metropolitan Okubo Hospital, Tokyo 160-8488, JapanDepartment of Endocrinology and Metabolism, Tokyo Metropolitan Okubo Hospital, Tokyo 160-8488, JapanDepartment of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, JapanDepartment of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, JapanDepartment of Endocrinology and Metabolism, Tokyo Metropolitan Okubo Hospital, Tokyo 160-8488, JapanBackground: It is not well known whether diabetic peripheral neuropathy diagnosed using a non-invasive point-of-care nerve conduction device called DPN-Check<sup>®</sup> is associated with diabetic nephropathy. Thus, we aimed to evaluate the association of diabetic peripheral neuropathy with urinary albumin excretion in patients with type 2 diabetes using DPN-Check<sup>®</sup>. Methods: This retrospective observational study included 323 Japanese patients with type 2 diabetes. The urinary albumin-to-creatinine ratio in a spot urine sample was defined as urinary albumin excretion. Multiple linear regression analysis was used to determine the association of DPN-Check<sup>®</sup>-determined diabetic peripheral neuropathy with urinary albumin excretion. Results: Patients with DPN-Check<sup>®</sup>-determined diabetic peripheral neuropathy had significantly higher urinary albumin excretion than those without, while there was no difference in urinary albumin excretion between patients with and without diabetic peripheral neuropathy determined by simplified diagnostic criteria. In the multivariate model, the DPN-Check<sup>®</sup> determined that diabetic peripheral neuropathy was significantly associated with urinary albumin excretion even after adjustment for covariates (standardized β, 0.123; <i>p</i> = 0.012). Conclusions: Our study found a significant association between diabetic peripheral neuropathy diagnosed using DPN-Check<sup>®</sup> and urinary albumin excretion in patients with type 2 diabetes.https://www.mdpi.com/2077-0383/12/12/4089DPN-Checkurinary albumin excretiontype 2 diabetesdiabetic peripheral neuropathysimplified diagnostic criteria |
| spellingShingle | Tatsuya Fukuda Akiko Fujii Taro Akihisa Naoya Otsubo Masanori Murakami Tetsuya Yamada Chisato Maki Association between Diabetic Peripheral Neuropathy as Measured Using a Point-of-Care Sural Nerve Conduction Device and Urinary Albumin Excretion in Patients with Type 2 Diabetes Journal of Clinical Medicine DPN-Check urinary albumin excretion type 2 diabetes diabetic peripheral neuropathy simplified diagnostic criteria |
| title | Association between Diabetic Peripheral Neuropathy as Measured Using a Point-of-Care Sural Nerve Conduction Device and Urinary Albumin Excretion in Patients with Type 2 Diabetes |
| title_full | Association between Diabetic Peripheral Neuropathy as Measured Using a Point-of-Care Sural Nerve Conduction Device and Urinary Albumin Excretion in Patients with Type 2 Diabetes |
| title_fullStr | Association between Diabetic Peripheral Neuropathy as Measured Using a Point-of-Care Sural Nerve Conduction Device and Urinary Albumin Excretion in Patients with Type 2 Diabetes |
| title_full_unstemmed | Association between Diabetic Peripheral Neuropathy as Measured Using a Point-of-Care Sural Nerve Conduction Device and Urinary Albumin Excretion in Patients with Type 2 Diabetes |
| title_short | Association between Diabetic Peripheral Neuropathy as Measured Using a Point-of-Care Sural Nerve Conduction Device and Urinary Albumin Excretion in Patients with Type 2 Diabetes |
| title_sort | association between diabetic peripheral neuropathy as measured using a point of care sural nerve conduction device and urinary albumin excretion in patients with type 2 diabetes |
| topic | DPN-Check urinary albumin excretion type 2 diabetes diabetic peripheral neuropathy simplified diagnostic criteria |
| url | https://www.mdpi.com/2077-0383/12/12/4089 |
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