Facile chemical modification of Nb2CTx MXene with ethylene diamine for sensitive electrochemical detection of dopamine from human serum samples
The electrochemical detection of dopamine (DA) is of ultimate importance in the early-stage diagnosis of Parkinson's and Alzheimer's diseases. In this work, we report the development of a facile amination technique of Nb2CTx MXenes for the electrochemical sensing of DA. The amination was c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Carbon Trends |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667056922000888 |
| _version_ | 1811297978328023040 |
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| author | Menon Ankitha Neermunda Shabana Ajith Mohan Arjun P Abdul Rasheed |
| author_facet | Menon Ankitha Neermunda Shabana Ajith Mohan Arjun P Abdul Rasheed |
| author_sort | Menon Ankitha |
| collection | DOAJ |
| description | The electrochemical detection of dopamine (DA) is of ultimate importance in the early-stage diagnosis of Parkinson's and Alzheimer's diseases. In this work, we report the development of a facile amination technique of Nb2CTx MXenes for the electrochemical sensing of DA. The amination was confirmed using fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy the structural changes due to the amination process were confirmed using X-Ray diffractograms. The modified MXenes were used to modify carbon cloth electrodes, which were then applied to the electrochemical detection of DA. The developed sensor was able to detect dopamine linearly in the range 1 nM–100 μM and a limit of detection of (LOD) of 300 pM was achieved. The modified electrode was found to have a selective response to DA in the presence of other interferents in addition to being reproducible and stable. The modified electrode was also used for the detection of DA in serum samples with little difference in the sensing characteristics in phosphate buffer. This work presents a novel amination route for the surface functionalization of Nb2CTx and opens new avenues for applications of surface functionalized Nb-MXenes in electrochemical detection of neurotransmitters. |
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| format | Article |
| id | doaj.art-da5f25f507f7418e8726ae89220bef1c |
| institution | Directory Open Access Journal |
| issn | 2667-0569 |
| language | English |
| last_indexed | 2024-04-13T06:13:03Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Carbon Trends |
| spelling | doaj.art-da5f25f507f7418e8726ae89220bef1c2022-12-22T02:58:57ZengElsevierCarbon Trends2667-05692022-10-019100232Facile chemical modification of Nb2CTx MXene with ethylene diamine for sensitive electrochemical detection of dopamine from human serum samplesMenon Ankitha0Neermunda Shabana1Ajith Mohan Arjun2P Abdul Rasheed3Department of Chemistry, Indian Institute of Technology Palakkad, Palakkad, Kerala, India 678 557Department of Chemistry, Indian Institute of Technology Palakkad, Palakkad, Kerala, India 678 557; Department of Biological Sciences and Engineering, Indian Institute of Technology Palakkad, Palakkad, Kerala, India 678 557Department of Biological Sciences and Engineering, Indian Institute of Technology Palakkad, Palakkad, Kerala, India 678 557Department of Chemistry, Indian Institute of Technology Palakkad, Palakkad, Kerala, India 678 557; Department of Biological Sciences and Engineering, Indian Institute of Technology Palakkad, Palakkad, Kerala, India 678 557; Corresponding authorThe electrochemical detection of dopamine (DA) is of ultimate importance in the early-stage diagnosis of Parkinson's and Alzheimer's diseases. In this work, we report the development of a facile amination technique of Nb2CTx MXenes for the electrochemical sensing of DA. The amination was confirmed using fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy the structural changes due to the amination process were confirmed using X-Ray diffractograms. The modified MXenes were used to modify carbon cloth electrodes, which were then applied to the electrochemical detection of DA. The developed sensor was able to detect dopamine linearly in the range 1 nM–100 μM and a limit of detection of (LOD) of 300 pM was achieved. The modified electrode was found to have a selective response to DA in the presence of other interferents in addition to being reproducible and stable. The modified electrode was also used for the detection of DA in serum samples with little difference in the sensing characteristics in phosphate buffer. This work presents a novel amination route for the surface functionalization of Nb2CTx and opens new avenues for applications of surface functionalized Nb-MXenes in electrochemical detection of neurotransmitters.http://www.sciencedirect.com/science/article/pii/S2667056922000888Ethylene diamineAminationElectrochemical detectiondopamineNb2CTx |
| spellingShingle | Menon Ankitha Neermunda Shabana Ajith Mohan Arjun P Abdul Rasheed Facile chemical modification of Nb2CTx MXene with ethylene diamine for sensitive electrochemical detection of dopamine from human serum samples Carbon Trends Ethylene diamine Amination Electrochemical detection dopamine Nb2CTx |
| title | Facile chemical modification of Nb2CTx MXene with ethylene diamine for sensitive electrochemical detection of dopamine from human serum samples |
| title_full | Facile chemical modification of Nb2CTx MXene with ethylene diamine for sensitive electrochemical detection of dopamine from human serum samples |
| title_fullStr | Facile chemical modification of Nb2CTx MXene with ethylene diamine for sensitive electrochemical detection of dopamine from human serum samples |
| title_full_unstemmed | Facile chemical modification of Nb2CTx MXene with ethylene diamine for sensitive electrochemical detection of dopamine from human serum samples |
| title_short | Facile chemical modification of Nb2CTx MXene with ethylene diamine for sensitive electrochemical detection of dopamine from human serum samples |
| title_sort | facile chemical modification of nb2ctx mxene with ethylene diamine for sensitive electrochemical detection of dopamine from human serum samples |
| topic | Ethylene diamine Amination Electrochemical detection dopamine Nb2CTx |
| url | http://www.sciencedirect.com/science/article/pii/S2667056922000888 |
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