Genetically engineered mouse models of pituitary tumors
Animal models constitute valuable tools for investigating the pathogenesis of cancer as well as for preclinical testing of novel therapeutics approaches. However, the pathogenic mechanisms of pituitary tumor formation remain poorly understood, particularly in sporadic adenomas, thus making it a chal...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-08-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00203/full |
| _version_ | 1817994919958020096 |
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| author | David A Cano David A Cano Alfonso eSoto-Moreno Alfonso eSoto-Moreno Alfonso eLeal-Cerro |
| author_facet | David A Cano David A Cano Alfonso eSoto-Moreno Alfonso eSoto-Moreno Alfonso eLeal-Cerro |
| author_sort | David A Cano |
| collection | DOAJ |
| description | Animal models constitute valuable tools for investigating the pathogenesis of cancer as well as for preclinical testing of novel therapeutics approaches. However, the pathogenic mechanisms of pituitary tumor formation remain poorly understood, particularly in sporadic adenomas, thus making it a challenge to model pituitary tumors in mice. Nevertheless, genetically engineered mouse models (GEMMs) of pituitary tumors have provided important insight into pituitary tumor biology. In this paper, we review various GEMMs of pituitary tumors, highlighting their contributions and limitations, and discuss opportunities for research in the field. |
| first_indexed | 2024-04-14T01:58:26Z |
| format | Article |
| id | doaj.art-da5f5c95d87f42679f7d3e407320e13d |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-14T01:58:26Z |
| publishDate | 2014-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-da5f5c95d87f42679f7d3e407320e13d2022-12-22T02:18:55ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2014-08-01410.3389/fonc.2014.00203105653Genetically engineered mouse models of pituitary tumorsDavid A Cano0David A Cano1Alfonso eSoto-Moreno2Alfonso eSoto-Moreno3Alfonso eLeal-Cerro4Institute of Biomedicine of Seville, Hospital Universitario Virgen del RocíoInstituto de Biomedicina de Sevilla (IBiS)Institute of Biomedicine of Seville, Hospital Universitario Virgen del RocíoInstituto de Biomedicina de Sevilla (IBiS)Instituto de Biomedicina de Sevilla (IBiS)Animal models constitute valuable tools for investigating the pathogenesis of cancer as well as for preclinical testing of novel therapeutics approaches. However, the pathogenic mechanisms of pituitary tumor formation remain poorly understood, particularly in sporadic adenomas, thus making it a challenge to model pituitary tumors in mice. Nevertheless, genetically engineered mouse models (GEMMs) of pituitary tumors have provided important insight into pituitary tumor biology. In this paper, we review various GEMMs of pituitary tumors, highlighting their contributions and limitations, and discuss opportunities for research in the field.http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00203/fullAdenomamouse modelsTransgenic micePituitaryGEMMs |
| spellingShingle | David A Cano David A Cano Alfonso eSoto-Moreno Alfonso eSoto-Moreno Alfonso eLeal-Cerro Genetically engineered mouse models of pituitary tumors Frontiers in Oncology Adenoma mouse models Transgenic mice Pituitary GEMMs |
| title | Genetically engineered mouse models of pituitary tumors |
| title_full | Genetically engineered mouse models of pituitary tumors |
| title_fullStr | Genetically engineered mouse models of pituitary tumors |
| title_full_unstemmed | Genetically engineered mouse models of pituitary tumors |
| title_short | Genetically engineered mouse models of pituitary tumors |
| title_sort | genetically engineered mouse models of pituitary tumors |
| topic | Adenoma mouse models Transgenic mice Pituitary GEMMs |
| url | http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00203/full |
| work_keys_str_mv | AT davidacano geneticallyengineeredmousemodelsofpituitarytumors AT davidacano geneticallyengineeredmousemodelsofpituitarytumors AT alfonsoesotomoreno geneticallyengineeredmousemodelsofpituitarytumors AT alfonsoesotomoreno geneticallyengineeredmousemodelsofpituitarytumors AT alfonsoelealcerro geneticallyengineeredmousemodelsofpituitarytumors |