Do methadone and buprenorphine have the same impact on psychopathological symptoms of heroin addicts?
<p>Abstract</p> <p>Background</p> <p>The idea that the impact of opioid agonist treatment is influenced by the psychopathological profile of heroin addicts has not yet been investigated, and is based on the concept of a specific therapeutic action displayed by opioid ag...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-05-01
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| Series: | Annals of General Psychiatry |
| Online Access: | http://www.annals-general-psychiatry.com/content/10/1/17 |
| _version_ | 1819034563790241792 |
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| author | Rugani Fabio Lamanna Francesco Pacini Matteo Pani Pier Rovai Luca Maremmani Angelo Schiavi Elisa Dell'Osso Liliana Maremmani Icro |
| author_facet | Rugani Fabio Lamanna Francesco Pacini Matteo Pani Pier Rovai Luca Maremmani Angelo Schiavi Elisa Dell'Osso Liliana Maremmani Icro |
| author_sort | Rugani Fabio |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The idea that the impact of opioid agonist treatment is influenced by the psychopathological profile of heroin addicts has not yet been investigated, and is based on the concept of a specific therapeutic action displayed by opioid agents on psychopathological symptoms. In the present report we compared the effects of buprenorphine and methadone on the psychopathological symptoms of 213 patients (106 on buprenorphine and 107 on methadone) in a follow-up study lasting 12 months.</p> <p>Methods</p> <p>Drug addiction history was collected by means of the Drug Addiction History Rating Scale (DAH-RS) and psychopathological features were collected by means of the Symptom Checklist-90 (SCL-90), using a special five-factor solution. Toxicological urinalyses were carried out for each patient during the treatment period.</p> <p>Results</p> <p>No statistically significant differences were detected in psychopathological symptoms, including 'worthlessness-being trapped', 'somatization', and 'panic-anxiety'. Methadone proved to be more effective on patients characterized by 'sensitivity-psychoticism', whereas buprenorphine was more effective on patients displaying a 'violence-suicide' symptomatology.</p> <p>Conclusions</p> <p>Heroin-dependent patients with psychiatric comorbidities may benefit from opioid agonist treatment not only because it targets their addictive problem, but also, precisely due to this, because it is effective against their mental disorder too.</p> |
| first_indexed | 2024-12-21T07:35:44Z |
| format | Article |
| id | doaj.art-da5f7c96ff674058a228e971f5323c7d |
| institution | Directory Open Access Journal |
| issn | 1744-859X |
| language | English |
| last_indexed | 2024-12-21T07:35:44Z |
| publishDate | 2011-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Annals of General Psychiatry |
| spelling | doaj.art-da5f7c96ff674058a228e971f5323c7d2022-12-21T19:11:27ZengBMCAnnals of General Psychiatry1744-859X2011-05-011011710.1186/1744-859X-10-17Do methadone and buprenorphine have the same impact on psychopathological symptoms of heroin addicts?Rugani FabioLamanna FrancescoPacini MatteoPani PierRovai LucaMaremmani AngeloSchiavi ElisaDell'Osso LilianaMaremmani Icro<p>Abstract</p> <p>Background</p> <p>The idea that the impact of opioid agonist treatment is influenced by the psychopathological profile of heroin addicts has not yet been investigated, and is based on the concept of a specific therapeutic action displayed by opioid agents on psychopathological symptoms. In the present report we compared the effects of buprenorphine and methadone on the psychopathological symptoms of 213 patients (106 on buprenorphine and 107 on methadone) in a follow-up study lasting 12 months.</p> <p>Methods</p> <p>Drug addiction history was collected by means of the Drug Addiction History Rating Scale (DAH-RS) and psychopathological features were collected by means of the Symptom Checklist-90 (SCL-90), using a special five-factor solution. Toxicological urinalyses were carried out for each patient during the treatment period.</p> <p>Results</p> <p>No statistically significant differences were detected in psychopathological symptoms, including 'worthlessness-being trapped', 'somatization', and 'panic-anxiety'. Methadone proved to be more effective on patients characterized by 'sensitivity-psychoticism', whereas buprenorphine was more effective on patients displaying a 'violence-suicide' symptomatology.</p> <p>Conclusions</p> <p>Heroin-dependent patients with psychiatric comorbidities may benefit from opioid agonist treatment not only because it targets their addictive problem, but also, precisely due to this, because it is effective against their mental disorder too.</p>http://www.annals-general-psychiatry.com/content/10/1/17 |
| spellingShingle | Rugani Fabio Lamanna Francesco Pacini Matteo Pani Pier Rovai Luca Maremmani Angelo Schiavi Elisa Dell'Osso Liliana Maremmani Icro Do methadone and buprenorphine have the same impact on psychopathological symptoms of heroin addicts? Annals of General Psychiatry |
| title | Do methadone and buprenorphine have the same impact on psychopathological symptoms of heroin addicts? |
| title_full | Do methadone and buprenorphine have the same impact on psychopathological symptoms of heroin addicts? |
| title_fullStr | Do methadone and buprenorphine have the same impact on psychopathological symptoms of heroin addicts? |
| title_full_unstemmed | Do methadone and buprenorphine have the same impact on psychopathological symptoms of heroin addicts? |
| title_short | Do methadone and buprenorphine have the same impact on psychopathological symptoms of heroin addicts? |
| title_sort | do methadone and buprenorphine have the same impact on psychopathological symptoms of heroin addicts |
| url | http://www.annals-general-psychiatry.com/content/10/1/17 |
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