Evaluation of cerebrospinal fluid ubiquitin C-terminal hydrolase-L1, glial fibrillary acidic protein, and neurofilament light protein as novel markers for the diagnosis of neurosyphilis among HIV-negative patients

Evaluation of cerebrospinal fluid ubiquitin C-terminal hydrolase-L1, glial fibrillary acidic protein, and neurofilament light protein as novel markers for the diagnosis of neurosyphilis among HIV-negative patients

ABSTRACT: Objectives: To evaluate the possibility of using cerebrospinal fluid (CSF) ubiquitin C-terminal hydrolase L1 (UCH-L1), glial fibrillary acidic protein (GFAP), and neurofilament light protein (NF-L) for the diagnosis of neurosyphilis (NS). Methods: A cross-sectional study of 576 subjects w...

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Bibliographic Details
Main Authors: Rui Chen, Li-Rong Lin, Yao Xiao, Wu-Jian Ke, Tian-Ci Yang
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:International Journal of Infectious Diseases
Subjects:
Neurosyphilis
UCH-L1
GFAP
NF-L
Diagnostic marker
Neuronal damage
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971222005999

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