The 12-Word Philadelphia Verbal Learning Test Performances in Older Adults: Brain MRI and Cerebrospinal Fluid Correlates and Regression-Based Normative Data
Background/Aims: This study evaluated neuroimaging and biological correlates, psychometric properties, and regression-based normative data of the 12-word Philadelphia Verbal Learning Test (PVLT), a list-learning test. Methods: Vanderbilt Memory and Aging Project participants free of clinical dementi...
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2018-12-01
|
| Series: | Dementia and Geriatric Cognitive Disorders Extra |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/494209 |
| _version_ | 1818449865419522048 |
|---|---|
| author | Katherine A. Gifford Dandan Liu Jacquelyn E. Neal Michelle A. Babicz Jennifer L. Thompson Lily E. Walljasper Margaret E. Wiggins Maxim Turchan Kimberly R. Pechman Katie E. Osborn Lealani Mae Y. Acosta Susan P. Bell Timothy J. Hohman David J. Libon Kaj Blennow Henrik Zetterberg Angela L. Jefferson |
| author_facet | Katherine A. Gifford Dandan Liu Jacquelyn E. Neal Michelle A. Babicz Jennifer L. Thompson Lily E. Walljasper Margaret E. Wiggins Maxim Turchan Kimberly R. Pechman Katie E. Osborn Lealani Mae Y. Acosta Susan P. Bell Timothy J. Hohman David J. Libon Kaj Blennow Henrik Zetterberg Angela L. Jefferson |
| author_sort | Katherine A. Gifford |
| collection | DOAJ |
| description | Background/Aims: This study evaluated neuroimaging and biological correlates, psychometric properties, and regression-based normative data of the 12-word Philadelphia Verbal Learning Test (PVLT), a list-learning test. Methods: Vanderbilt Memory and Aging Project participants free of clinical dementia and stroke (n = 230, aged 73 ± 7 years) completed a neuropsychological protocol and brain MRI. A subset (n = 111) underwent lumbar puncture for analysis of Alzheimer’s disease (AD) and axonal integrity cerebrospinal fluid (CSF) biomarkers. Regression models related PVLT indices to MRI and CSF biomarkers adjusting for age, sex, race/ethnicity, education, APOE-ε4 carrier status, cognitive status, and intracranial volume (MRI models). Secondary analyses were restricted to participants with normal cognition (NC; n = 127), from which regression-based normative data were generated. Results: Lower PVLT performances were associated with smaller medial temporal lobe volumes (p < 0.05) and higher CSF tau concentrations (p < 0.04). Among NC, PVLT indices were associated with white matter hyperintensities on MRI and an axonal injury biomarker (CSF neurofilament light; p < 0.03). Conclusion: The PVLT appears sensitive to markers of neurodegeneration, including temporal regions affected by AD. Conversely, in cognitively normal older adults, PVLT performance seems to relate to white matter disease and axonal injury, perhaps reflecting non-AD pathways to cognitive change. Enhanced normative data enrich the clinical utility of this tool. |
| first_indexed | 2024-12-14T20:42:12Z |
| format | Article |
| id | doaj.art-da62f2645bb448c0889f8a96da2ed5f2 |
| institution | Directory Open Access Journal |
| issn | 1664-5464 |
| language | English |
| last_indexed | 2024-12-14T20:42:12Z |
| publishDate | 2018-12-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Dementia and Geriatric Cognitive Disorders Extra |
| spelling | doaj.art-da62f2645bb448c0889f8a96da2ed5f22022-12-21T22:48:13ZengKarger PublishersDementia and Geriatric Cognitive Disorders Extra1664-54642018-12-018347649110.1159/000494209494209The 12-Word Philadelphia Verbal Learning Test Performances in Older Adults: Brain MRI and Cerebrospinal Fluid Correlates and Regression-Based Normative DataKatherine A. GiffordDandan LiuJacquelyn E. NealMichelle A. BabiczJennifer L. ThompsonLily E. WalljasperMargaret E. WigginsMaxim TurchanKimberly R. PechmanKatie E. OsbornLealani Mae Y. AcostaSusan P. BellTimothy J. HohmanDavid J. LibonKaj BlennowHenrik ZetterbergAngela L. JeffersonBackground/Aims: This study evaluated neuroimaging and biological correlates, psychometric properties, and regression-based normative data of the 12-word Philadelphia Verbal Learning Test (PVLT), a list-learning test. Methods: Vanderbilt Memory and Aging Project participants free of clinical dementia and stroke (n = 230, aged 73 ± 7 years) completed a neuropsychological protocol and brain MRI. A subset (n = 111) underwent lumbar puncture for analysis of Alzheimer’s disease (AD) and axonal integrity cerebrospinal fluid (CSF) biomarkers. Regression models related PVLT indices to MRI and CSF biomarkers adjusting for age, sex, race/ethnicity, education, APOE-ε4 carrier status, cognitive status, and intracranial volume (MRI models). Secondary analyses were restricted to participants with normal cognition (NC; n = 127), from which regression-based normative data were generated. Results: Lower PVLT performances were associated with smaller medial temporal lobe volumes (p < 0.05) and higher CSF tau concentrations (p < 0.04). Among NC, PVLT indices were associated with white matter hyperintensities on MRI and an axonal injury biomarker (CSF neurofilament light; p < 0.03). Conclusion: The PVLT appears sensitive to markers of neurodegeneration, including temporal regions affected by AD. Conversely, in cognitively normal older adults, PVLT performance seems to relate to white matter disease and axonal injury, perhaps reflecting non-AD pathways to cognitive change. Enhanced normative data enrich the clinical utility of this tool.https://www.karger.com/Article/FullText/494209AgingAlzheimer’s diseaseBiomarkersEpisodic memoryPsychometricsNormative dataStructural neuroimagingTemporal lobeWhite matter hyperintensitiesCerebrospinal fluid |
| spellingShingle | Katherine A. Gifford Dandan Liu Jacquelyn E. Neal Michelle A. Babicz Jennifer L. Thompson Lily E. Walljasper Margaret E. Wiggins Maxim Turchan Kimberly R. Pechman Katie E. Osborn Lealani Mae Y. Acosta Susan P. Bell Timothy J. Hohman David J. Libon Kaj Blennow Henrik Zetterberg Angela L. Jefferson The 12-Word Philadelphia Verbal Learning Test Performances in Older Adults: Brain MRI and Cerebrospinal Fluid Correlates and Regression-Based Normative Data Dementia and Geriatric Cognitive Disorders Extra Aging Alzheimer’s disease Biomarkers Episodic memory Psychometrics Normative data Structural neuroimaging Temporal lobe White matter hyperintensities Cerebrospinal fluid |
| title | The 12-Word Philadelphia Verbal Learning Test Performances in Older Adults: Brain MRI and Cerebrospinal Fluid Correlates and Regression-Based Normative Data |
| title_full | The 12-Word Philadelphia Verbal Learning Test Performances in Older Adults: Brain MRI and Cerebrospinal Fluid Correlates and Regression-Based Normative Data |
| title_fullStr | The 12-Word Philadelphia Verbal Learning Test Performances in Older Adults: Brain MRI and Cerebrospinal Fluid Correlates and Regression-Based Normative Data |
| title_full_unstemmed | The 12-Word Philadelphia Verbal Learning Test Performances in Older Adults: Brain MRI and Cerebrospinal Fluid Correlates and Regression-Based Normative Data |
| title_short | The 12-Word Philadelphia Verbal Learning Test Performances in Older Adults: Brain MRI and Cerebrospinal Fluid Correlates and Regression-Based Normative Data |
| title_sort | 12 word philadelphia verbal learning test performances in older adults brain mri and cerebrospinal fluid correlates and regression based normative data |
| topic | Aging Alzheimer’s disease Biomarkers Episodic memory Psychometrics Normative data Structural neuroimaging Temporal lobe White matter hyperintensities Cerebrospinal fluid |
| url | https://www.karger.com/Article/FullText/494209 |
| work_keys_str_mv | AT katherineagifford the12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT dandanliu the12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT jacquelyneneal the12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT michelleababicz the12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT jenniferlthompson the12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT lilyewalljasper the12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT margaretewiggins the12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT maximturchan the12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT kimberlyrpechman the12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT katieeosborn the12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT lealanimaeyacosta the12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT susanpbell the12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT timothyjhohman the12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT davidjlibon the12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT kajblennow the12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT henrikzetterberg the12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT angelaljefferson the12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT katherineagifford 12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT dandanliu 12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT jacquelyneneal 12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT michelleababicz 12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT jenniferlthompson 12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT lilyewalljasper 12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT margaretewiggins 12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT maximturchan 12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT kimberlyrpechman 12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT katieeosborn 12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT lealanimaeyacosta 12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT susanpbell 12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT timothyjhohman 12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT davidjlibon 12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT kajblennow 12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT henrikzetterberg 12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata AT angelaljefferson 12wordphiladelphiaverballearningtestperformancesinolderadultsbrainmriandcerebrospinalfluidcorrelatesandregressionbasednormativedata |