Improved islet function is associated with anti-inflammatory, antioxidant and hypoglycemic potential of cinnamaldehyde on metabolic syndrome induced by high tail fat in rats
Cinnamon is used in traditional medicine and foods. In this study the protective effects of cinnamaldehyde, one of the most abundant compound of cinnamon against metabolic syndrome induced by high fat diet, were investigated. To induce metabolic syndrome, male Wistar rats were given high fat diet fo...
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| Format: | Article |
| Language: | English |
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Elsevier
2014-09-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464614002424 |
| _version_ | 1819055237183307776 |
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| author | Khadije Farrokhfall Ali Khoshbaten Saleh Zahediasl Hossein Mehrani Narges Karbalaei |
| author_facet | Khadije Farrokhfall Ali Khoshbaten Saleh Zahediasl Hossein Mehrani Narges Karbalaei |
| author_sort | Khadije Farrokhfall |
| collection | DOAJ |
| description | Cinnamon is used in traditional medicine and foods. In this study the protective effects of cinnamaldehyde, one of the most abundant compound of cinnamon against metabolic syndrome induced by high fat diet, were investigated. To induce metabolic syndrome, male Wistar rats were given high fat diet for 16 weeks. Cinnamaldehyde was administrated orally (143.8 µmol/kg body weight) concomitant with high fat feed. Changes in islet morphology, lipid profile, TNF-α, TBARS, insulin resistance were analyzed. Metabolic syndrome was induced by high fat diet. Cinnamaldehyde reversed this process and significantly reduced insulin secretion and content in isolated islets of high fat diet. Beta cell enlargement, TNF-α and TBARS significantly increased with high fat diet, cinnamaldehyde restored both to the control level. Cinnamaldehyde prevented all symptoms of metabolic syndrome by improving oxidative and inflammatory conditions in pancreatic islets with no effect on insulin secretion but by enhancing insulin reserve and preventing beta cell damage. |
| first_indexed | 2024-12-21T13:04:19Z |
| format | Article |
| id | doaj.art-da63bb557ddb4aeeb7bca3b2270ca610 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-21T13:04:19Z |
| publishDate | 2014-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-da63bb557ddb4aeeb7bca3b2270ca6102022-12-21T19:03:05ZengElsevierJournal of Functional Foods1756-46462014-09-0110397406Improved islet function is associated with anti-inflammatory, antioxidant and hypoglycemic potential of cinnamaldehyde on metabolic syndrome induced by high tail fat in ratsKhadije Farrokhfall0Ali Khoshbaten1Saleh Zahediasl2Hossein Mehrani3Narges Karbalaei4Neurosciences Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran; Department of Physiology and Biophysics, Faculty of Medicine, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, IranDepartment of Physiology and Biophysics, Faculty of Medicine, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, IranEndocrine Physiology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranLaboratory of Proteomics, Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran; Corresponding author. Tel.: +98 21 88211524; fax: +98 21 88211524.Department of Physiology, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, IranCinnamon is used in traditional medicine and foods. In this study the protective effects of cinnamaldehyde, one of the most abundant compound of cinnamon against metabolic syndrome induced by high fat diet, were investigated. To induce metabolic syndrome, male Wistar rats were given high fat diet for 16 weeks. Cinnamaldehyde was administrated orally (143.8 µmol/kg body weight) concomitant with high fat feed. Changes in islet morphology, lipid profile, TNF-α, TBARS, insulin resistance were analyzed. Metabolic syndrome was induced by high fat diet. Cinnamaldehyde reversed this process and significantly reduced insulin secretion and content in isolated islets of high fat diet. Beta cell enlargement, TNF-α and TBARS significantly increased with high fat diet, cinnamaldehyde restored both to the control level. Cinnamaldehyde prevented all symptoms of metabolic syndrome by improving oxidative and inflammatory conditions in pancreatic islets with no effect on insulin secretion but by enhancing insulin reserve and preventing beta cell damage.http://www.sciencedirect.com/science/article/pii/S1756464614002424High fat dietCinnamaldehydeMetabolic syndromeOxidative stressRat |
| spellingShingle | Khadije Farrokhfall Ali Khoshbaten Saleh Zahediasl Hossein Mehrani Narges Karbalaei Improved islet function is associated with anti-inflammatory, antioxidant and hypoglycemic potential of cinnamaldehyde on metabolic syndrome induced by high tail fat in rats Journal of Functional Foods High fat diet Cinnamaldehyde Metabolic syndrome Oxidative stress Rat |
| title | Improved islet function is associated with anti-inflammatory, antioxidant and hypoglycemic potential of cinnamaldehyde on metabolic syndrome induced by high tail fat in rats |
| title_full | Improved islet function is associated with anti-inflammatory, antioxidant and hypoglycemic potential of cinnamaldehyde on metabolic syndrome induced by high tail fat in rats |
| title_fullStr | Improved islet function is associated with anti-inflammatory, antioxidant and hypoglycemic potential of cinnamaldehyde on metabolic syndrome induced by high tail fat in rats |
| title_full_unstemmed | Improved islet function is associated with anti-inflammatory, antioxidant and hypoglycemic potential of cinnamaldehyde on metabolic syndrome induced by high tail fat in rats |
| title_short | Improved islet function is associated with anti-inflammatory, antioxidant and hypoglycemic potential of cinnamaldehyde on metabolic syndrome induced by high tail fat in rats |
| title_sort | improved islet function is associated with anti inflammatory antioxidant and hypoglycemic potential of cinnamaldehyde on metabolic syndrome induced by high tail fat in rats |
| topic | High fat diet Cinnamaldehyde Metabolic syndrome Oxidative stress Rat |
| url | http://www.sciencedirect.com/science/article/pii/S1756464614002424 |
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