A red blood cell‐derived bionic microrobot capable of hierarchically adapting to five critical stages in systemic drug delivery
Abstract The tumour‐targeting efficiency of systemically delivered chemodrugs largely dictates the therapeutic outcome of anticancer treatment. Major challenges lie in the complexity of diverse biological barriers that drug delivery systems must hierarchically overcome to reach their cellular/subcel...
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| Format: | Article |
| Language: | English |
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Wiley
2024-04-01
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| Series: | Exploration |
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| Online Access: | https://doi.org/10.1002/EXP.20230105 |
| _version_ | 1797202570663428096 |
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| author | Ya‐Xuan Zhu Hao‐Ran Jia Yao‐Wen Jiang Yuxin Guo Qiu‐Yi Duan Ke‐Fei Xu Bai‐Hui Shan Xiaoyang Liu Xiaokai Chen Fu‐Gen Wu |
| author_facet | Ya‐Xuan Zhu Hao‐Ran Jia Yao‐Wen Jiang Yuxin Guo Qiu‐Yi Duan Ke‐Fei Xu Bai‐Hui Shan Xiaoyang Liu Xiaokai Chen Fu‐Gen Wu |
| author_sort | Ya‐Xuan Zhu |
| collection | DOAJ |
| description | Abstract The tumour‐targeting efficiency of systemically delivered chemodrugs largely dictates the therapeutic outcome of anticancer treatment. Major challenges lie in the complexity of diverse biological barriers that drug delivery systems must hierarchically overcome to reach their cellular/subcellular targets. Herein, an “all‐in‐one” red blood cell (RBC)‐derived microrobot that can hierarchically adapt to five critical stages during systemic drug delivery, that is, circulation, accumulation, release, extravasation, and penetration, is developed. The microrobots behave like natural RBCs in blood circulation, due to their almost identical surface properties, but can be magnetically manipulated to accumulate at regions of interest such as tumours. Next, the microrobots are “immolated” under laser irradiation to release their therapeutic cargoes and, by generating heat, to enhance drug extravasation through vascular barriers. As a coloaded agent, pirfenidone (PFD) can inhibit the formation of extracellular matrix and increase the penetration depth of chemodrugs in the solid tumour. It is demonstrated that this system effectively suppresses both primary and metastatic tumours in mouse models without evident side effects, and may represent a new class of intelligent biomimicking robots for biomedical applications. |
| first_indexed | 2024-04-24T08:05:33Z |
| format | Article |
| id | doaj.art-da63e294bbeb48168382095de3daa091 |
| institution | Directory Open Access Journal |
| issn | 2766-8509 2766-2098 |
| language | English |
| last_indexed | 2024-04-24T08:05:33Z |
| publishDate | 2024-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Exploration |
| spelling | doaj.art-da63e294bbeb48168382095de3daa0912024-04-17T12:18:39ZengWileyExploration2766-85092766-20982024-04-0142n/an/a10.1002/EXP.20230105A red blood cell‐derived bionic microrobot capable of hierarchically adapting to five critical stages in systemic drug deliveryYa‐Xuan Zhu0Hao‐Ran Jia1Yao‐Wen Jiang2Yuxin Guo3Qiu‐Yi Duan4Ke‐Fei Xu5Bai‐Hui Shan6Xiaoyang Liu7Xiaokai Chen8Fu‐Gen Wu9State Key Laboratory of Digital Medical Engineering Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Science and Medical Engineering Southeast University Nanjing Jiangsu People's Republic of ChinaState Key Laboratory of Digital Medical Engineering Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Science and Medical Engineering Southeast University Nanjing Jiangsu People's Republic of ChinaState Key Laboratory of Digital Medical Engineering Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Science and Medical Engineering Southeast University Nanjing Jiangsu People's Republic of ChinaState Key Laboratory of Digital Medical Engineering Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Science and Medical Engineering Southeast University Nanjing Jiangsu People's Republic of ChinaState Key Laboratory of Digital Medical Engineering Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Science and Medical Engineering Southeast University Nanjing Jiangsu People's Republic of ChinaState Key Laboratory of Digital Medical Engineering Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Science and Medical Engineering Southeast University Nanjing Jiangsu People's Republic of ChinaState Key Laboratory of Digital Medical Engineering Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Science and Medical Engineering Southeast University Nanjing Jiangsu People's Republic of ChinaState Key Laboratory of Digital Medical Engineering Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Science and Medical Engineering Southeast University Nanjing Jiangsu People's Republic of ChinaSchool of Chemistry Chemical Engineering and Biotechnology Nanyang Technological University Singapore SingaporeState Key Laboratory of Digital Medical Engineering Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Science and Medical Engineering Southeast University Nanjing Jiangsu People's Republic of ChinaAbstract The tumour‐targeting efficiency of systemically delivered chemodrugs largely dictates the therapeutic outcome of anticancer treatment. Major challenges lie in the complexity of diverse biological barriers that drug delivery systems must hierarchically overcome to reach their cellular/subcellular targets. Herein, an “all‐in‐one” red blood cell (RBC)‐derived microrobot that can hierarchically adapt to five critical stages during systemic drug delivery, that is, circulation, accumulation, release, extravasation, and penetration, is developed. The microrobots behave like natural RBCs in blood circulation, due to their almost identical surface properties, but can be magnetically manipulated to accumulate at regions of interest such as tumours. Next, the microrobots are “immolated” under laser irradiation to release their therapeutic cargoes and, by generating heat, to enhance drug extravasation through vascular barriers. As a coloaded agent, pirfenidone (PFD) can inhibit the formation of extracellular matrix and increase the penetration depth of chemodrugs in the solid tumour. It is demonstrated that this system effectively suppresses both primary and metastatic tumours in mouse models without evident side effects, and may represent a new class of intelligent biomimicking robots for biomedical applications.https://doi.org/10.1002/EXP.20230105deep tumour penetrationdual‐controllablelaser‐triggered drug releasemagnetic guidancemicrorobot |
| spellingShingle | Ya‐Xuan Zhu Hao‐Ran Jia Yao‐Wen Jiang Yuxin Guo Qiu‐Yi Duan Ke‐Fei Xu Bai‐Hui Shan Xiaoyang Liu Xiaokai Chen Fu‐Gen Wu A red blood cell‐derived bionic microrobot capable of hierarchically adapting to five critical stages in systemic drug delivery Exploration deep tumour penetration dual‐controllable laser‐triggered drug release magnetic guidance microrobot |
| title | A red blood cell‐derived bionic microrobot capable of hierarchically adapting to five critical stages in systemic drug delivery |
| title_full | A red blood cell‐derived bionic microrobot capable of hierarchically adapting to five critical stages in systemic drug delivery |
| title_fullStr | A red blood cell‐derived bionic microrobot capable of hierarchically adapting to five critical stages in systemic drug delivery |
| title_full_unstemmed | A red blood cell‐derived bionic microrobot capable of hierarchically adapting to five critical stages in systemic drug delivery |
| title_short | A red blood cell‐derived bionic microrobot capable of hierarchically adapting to five critical stages in systemic drug delivery |
| title_sort | red blood cell derived bionic microrobot capable of hierarchically adapting to five critical stages in systemic drug delivery |
| topic | deep tumour penetration dual‐controllable laser‐triggered drug release magnetic guidance microrobot |
| url | https://doi.org/10.1002/EXP.20230105 |
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