Liquid Biopsy in Squamous Cell Carcinoma of the Esophagus and of the Head and Neck
Squamous cell carcinomas of the esophagus (ESCC) and of the head and neck (HNSCC) are two neoplasms that share common risk factors and have the same embryological origin, but a very different prognosis, the 5-year survival of HNSCC being almost double (40–50%) compared to the 5-year survival of ESCC...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.827297/full |
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| author | Razvan Iacob Razvan Iacob Razvan Iacob Matei Mandea Speranta Iacob Speranta Iacob Speranta Iacob Catalina Pietrosanu Catalina Pietrosanu Doru Paul Razvan Hainarosie Razvan Hainarosie Cristian Gheorghe Cristian Gheorghe Cristian Gheorghe |
| author_facet | Razvan Iacob Razvan Iacob Razvan Iacob Matei Mandea Speranta Iacob Speranta Iacob Speranta Iacob Catalina Pietrosanu Catalina Pietrosanu Doru Paul Razvan Hainarosie Razvan Hainarosie Cristian Gheorghe Cristian Gheorghe Cristian Gheorghe |
| author_sort | Razvan Iacob |
| collection | DOAJ |
| description | Squamous cell carcinomas of the esophagus (ESCC) and of the head and neck (HNSCC) are two neoplasms that share common risk factors and have the same embryological origin, but a very different prognosis, the 5-year survival of HNSCC being almost double (40–50%) compared to the 5-year survival of ESCC (20%). Current guidelines emphasize the importance of screening for ESCC in patients diagnosed with head and neck cancers. A liquid biopsy is a novel tool for diagnosis, prognostic stratification, and personalized therapy. Liquid biopsy biomarkers for these two malignancies could help both their early detection, facilitate residual disease identification, and provide prognosis information. The present systematic review of the literature was aimed at describing the liquid biopsy biomarkers present in these two malignancies, with an emphasis on potential clinical applications. |
| first_indexed | 2024-12-11T13:13:25Z |
| format | Article |
| id | doaj.art-da6435d6e3ff45328da4b6df69d7bddc |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-11T13:13:25Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-da6435d6e3ff45328da4b6df69d7bddc2022-12-22T01:06:08ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-04-01910.3389/fmed.2022.827297827297Liquid Biopsy in Squamous Cell Carcinoma of the Esophagus and of the Head and NeckRazvan Iacob0Razvan Iacob1Razvan Iacob2Matei Mandea3Speranta Iacob4Speranta Iacob5Speranta Iacob6Catalina Pietrosanu7Catalina Pietrosanu8Doru Paul9Razvan Hainarosie10Razvan Hainarosie11Cristian Gheorghe12Cristian Gheorghe13Cristian Gheorghe14University of Medicine and Pharmacy “Carol Davila”, Bucharest, RomaniaDigestive Diseases and Liver Transplantation Center, Fundeni Clinical Institute, Bucharest, RomaniaCenter of Excellence in Translational Medicine, Fundeni Clinical Institute, Bucharest, RomaniaUniversity of Medicine and Pharmacy “Carol Davila”, Bucharest, RomaniaUniversity of Medicine and Pharmacy “Carol Davila”, Bucharest, RomaniaDigestive Diseases and Liver Transplantation Center, Fundeni Clinical Institute, Bucharest, RomaniaCenter of Excellence in Translational Medicine, Fundeni Clinical Institute, Bucharest, RomaniaUniversity of Medicine and Pharmacy “Carol Davila”, Bucharest, RomaniaProfessor Doctor Dorin Hociota Institute of Phonoaudiology and Functional ENT Surgery, Bucharest, RomaniaDivision of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, United StatesUniversity of Medicine and Pharmacy “Carol Davila”, Bucharest, RomaniaProfessor Doctor Dorin Hociota Institute of Phonoaudiology and Functional ENT Surgery, Bucharest, RomaniaUniversity of Medicine and Pharmacy “Carol Davila”, Bucharest, RomaniaDigestive Diseases and Liver Transplantation Center, Fundeni Clinical Institute, Bucharest, RomaniaCenter of Excellence in Translational Medicine, Fundeni Clinical Institute, Bucharest, RomaniaSquamous cell carcinomas of the esophagus (ESCC) and of the head and neck (HNSCC) are two neoplasms that share common risk factors and have the same embryological origin, but a very different prognosis, the 5-year survival of HNSCC being almost double (40–50%) compared to the 5-year survival of ESCC (20%). Current guidelines emphasize the importance of screening for ESCC in patients diagnosed with head and neck cancers. A liquid biopsy is a novel tool for diagnosis, prognostic stratification, and personalized therapy. Liquid biopsy biomarkers for these two malignancies could help both their early detection, facilitate residual disease identification, and provide prognosis information. The present systematic review of the literature was aimed at describing the liquid biopsy biomarkers present in these two malignancies, with an emphasis on potential clinical applications.https://www.frontiersin.org/articles/10.3389/fmed.2022.827297/fullliquid biopsyesophageal squamous cell carcinomahead and neck squamous cell carcinomacell free DNAcirculating tumor cellsexosomes |
| spellingShingle | Razvan Iacob Razvan Iacob Razvan Iacob Matei Mandea Speranta Iacob Speranta Iacob Speranta Iacob Catalina Pietrosanu Catalina Pietrosanu Doru Paul Razvan Hainarosie Razvan Hainarosie Cristian Gheorghe Cristian Gheorghe Cristian Gheorghe Liquid Biopsy in Squamous Cell Carcinoma of the Esophagus and of the Head and Neck Frontiers in Medicine liquid biopsy esophageal squamous cell carcinoma head and neck squamous cell carcinoma cell free DNA circulating tumor cells exosomes |
| title | Liquid Biopsy in Squamous Cell Carcinoma of the Esophagus and of the Head and Neck |
| title_full | Liquid Biopsy in Squamous Cell Carcinoma of the Esophagus and of the Head and Neck |
| title_fullStr | Liquid Biopsy in Squamous Cell Carcinoma of the Esophagus and of the Head and Neck |
| title_full_unstemmed | Liquid Biopsy in Squamous Cell Carcinoma of the Esophagus and of the Head and Neck |
| title_short | Liquid Biopsy in Squamous Cell Carcinoma of the Esophagus and of the Head and Neck |
| title_sort | liquid biopsy in squamous cell carcinoma of the esophagus and of the head and neck |
| topic | liquid biopsy esophageal squamous cell carcinoma head and neck squamous cell carcinoma cell free DNA circulating tumor cells exosomes |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.827297/full |
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