Fabricating Aptamer-functionalized Ti3C2 therapeutic nanoplatform for targeted chemo-photothermal therapy of cancer
Aptamer (Apt) is a kind of recognition molecule with excellent affinity and high specificity. Transmembrane glycoprotein mucin (MUC1) is an important tumor biomarker overexpressed in MCF-7 tumor cells. MUC1 Apt (Apt-M) could specifically target MCF-7 tumor cells. Ti3C2 nanosheets with high photother...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Materials & Design |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127523000710 |
| _version_ | 1811158470795198464 |
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| author | Zhiqiang Bai Lu Zhao Haidi Feng Hui Xu Nianping Zhang Yanjun Li Jinping Song Yunfeng Bai Ronghua Yang Feng Feng |
| author_facet | Zhiqiang Bai Lu Zhao Haidi Feng Hui Xu Nianping Zhang Yanjun Li Jinping Song Yunfeng Bai Ronghua Yang Feng Feng |
| author_sort | Zhiqiang Bai |
| collection | DOAJ |
| description | Aptamer (Apt) is a kind of recognition molecule with excellent affinity and high specificity. Transmembrane glycoprotein mucin (MUC1) is an important tumor biomarker overexpressed in MCF-7 tumor cells. MUC1 Apt (Apt-M) could specifically target MCF-7 tumor cells. Ti3C2 nanosheets with high photothermal conversion efficiency were considered as a promising therapeutic nanoplatform for tumor therapy. Doxorubicin (DOX) is a common anti-tumor drug. Herein, a novel DOX/Ti3C2/Apt-M therapeutic nanoplatform was successfully fabricated, which could specifically target MCF-7 tumor cells. As expected, the temperature of DOX/Ti3C2/Apt-M therapeutic nanoplatform raised rapidly under laser irradiation. Meanwhile, chemotherapy was triggered through multimodal stimuli-responsive drug release from the DOX/Ti3C2/Apt-M therapeutic nanoplatform under acidic environment and laser-induced local high temperature. Encouragingly, the MCF-7 cell viability of DOX/Ti3C2/Apt-M with laser irradiation was only 26.9%. The tumor surface temperature of MCF-7 xenograft mice in the DOX/Ti3C2/Apt-M + Laser group rose to about 58.3 °C, which was significantly higher than other laser irradiation groups. The experiments in vitro and in vivo indicated that the DOX/Ti3C2/Apt-M therapeutic nanoplatform can rapidly accumulate in MCF-7 tumors with excellent active targeting properties, and display superior tumor suppressive ability through combination therapy. This work provides a new idea of targeted tumor therapy based on Ti3C2 nanosheets. |
| first_indexed | 2024-04-10T05:25:16Z |
| format | Article |
| id | doaj.art-da65046e4e6a4ed2b981dd09477147b8 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-04-10T05:25:16Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-da65046e4e6a4ed2b981dd09477147b82023-03-08T04:13:45ZengElsevierMaterials & Design0264-12752023-02-01226111656Fabricating Aptamer-functionalized Ti3C2 therapeutic nanoplatform for targeted chemo-photothermal therapy of cancerZhiqiang Bai0Lu Zhao1Haidi Feng2Hui Xu3Nianping Zhang4Yanjun Li5Jinping Song6Yunfeng Bai7Ronghua Yang8Feng Feng9School of Chemistry and Material Science, Shanxi Normal University, Taiyuan 030002, PR China; School of Chemistry and Chemical Engineering, Shanxi Provincial Key Laboratory of Chemical Biosensing, Shanxi Datong University, Datong 037009, PR ChinaSchool of Chemistry and Chemical Engineering, Shanxi Provincial Key Laboratory of Chemical Biosensing, Shanxi Datong University, Datong 037009, PR ChinaSchool of Chemistry and Chemical Engineering, Shanxi Provincial Key Laboratory of Chemical Biosensing, Shanxi Datong University, Datong 037009, PR ChinaSchool of Chemistry and Chemical Engineering, Shanxi Provincial Key Laboratory of Chemical Biosensing, Shanxi Datong University, Datong 037009, PR ChinaSchool of Medical, Shanxi Datong University, Datong 037009, PR ChinaSchool of Medical, Shanxi Datong University, Datong 037009, PR ChinaSchool of Chemistry and Chemical Engineering, Shanxi Provincial Key Laboratory of Chemical Biosensing, Shanxi Datong University, Datong 037009, PR ChinaSchool of Chemistry and Chemical Engineering, Shanxi Provincial Key Laboratory of Chemical Biosensing, Shanxi Datong University, Datong 037009, PR China; Corresponding authors at: School of Chemistry and Material Science, Shanxi Normal University, Taiyuan 030002, PR China (F. Feng).Hunan Provincial Key Laboratory of Cytochemistry, School of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha 410004, PR China; Corresponding authors at: School of Chemistry and Material Science, Shanxi Normal University, Taiyuan 030002, PR China (F. Feng).School of Chemistry and Material Science, Shanxi Normal University, Taiyuan 030002, PR China; School of Chemistry and Chemical Engineering, Shanxi Provincial Key Laboratory of Chemical Biosensing, Shanxi Datong University, Datong 037009, PR China; School Department of Energy Chemistry and Materials Engineering, Shanxi Institute of Energy, Taiyuan 030600, PR China; Corresponding authors at: School of Chemistry and Material Science, Shanxi Normal University, Taiyuan 030002, PR China (F. Feng).Aptamer (Apt) is a kind of recognition molecule with excellent affinity and high specificity. Transmembrane glycoprotein mucin (MUC1) is an important tumor biomarker overexpressed in MCF-7 tumor cells. MUC1 Apt (Apt-M) could specifically target MCF-7 tumor cells. Ti3C2 nanosheets with high photothermal conversion efficiency were considered as a promising therapeutic nanoplatform for tumor therapy. Doxorubicin (DOX) is a common anti-tumor drug. Herein, a novel DOX/Ti3C2/Apt-M therapeutic nanoplatform was successfully fabricated, which could specifically target MCF-7 tumor cells. As expected, the temperature of DOX/Ti3C2/Apt-M therapeutic nanoplatform raised rapidly under laser irradiation. Meanwhile, chemotherapy was triggered through multimodal stimuli-responsive drug release from the DOX/Ti3C2/Apt-M therapeutic nanoplatform under acidic environment and laser-induced local high temperature. Encouragingly, the MCF-7 cell viability of DOX/Ti3C2/Apt-M with laser irradiation was only 26.9%. The tumor surface temperature of MCF-7 xenograft mice in the DOX/Ti3C2/Apt-M + Laser group rose to about 58.3 °C, which was significantly higher than other laser irradiation groups. The experiments in vitro and in vivo indicated that the DOX/Ti3C2/Apt-M therapeutic nanoplatform can rapidly accumulate in MCF-7 tumors with excellent active targeting properties, and display superior tumor suppressive ability through combination therapy. This work provides a new idea of targeted tumor therapy based on Ti3C2 nanosheets.http://www.sciencedirect.com/science/article/pii/S0264127523000710Ti3C2AptamerTargetedChemo-photothermal therapyCancer |
| spellingShingle | Zhiqiang Bai Lu Zhao Haidi Feng Hui Xu Nianping Zhang Yanjun Li Jinping Song Yunfeng Bai Ronghua Yang Feng Feng Fabricating Aptamer-functionalized Ti3C2 therapeutic nanoplatform for targeted chemo-photothermal therapy of cancer Materials & Design Ti3C2 Aptamer Targeted Chemo-photothermal therapy Cancer |
| title | Fabricating Aptamer-functionalized Ti3C2 therapeutic nanoplatform for targeted chemo-photothermal therapy of cancer |
| title_full | Fabricating Aptamer-functionalized Ti3C2 therapeutic nanoplatform for targeted chemo-photothermal therapy of cancer |
| title_fullStr | Fabricating Aptamer-functionalized Ti3C2 therapeutic nanoplatform for targeted chemo-photothermal therapy of cancer |
| title_full_unstemmed | Fabricating Aptamer-functionalized Ti3C2 therapeutic nanoplatform for targeted chemo-photothermal therapy of cancer |
| title_short | Fabricating Aptamer-functionalized Ti3C2 therapeutic nanoplatform for targeted chemo-photothermal therapy of cancer |
| title_sort | fabricating aptamer functionalized ti3c2 therapeutic nanoplatform for targeted chemo photothermal therapy of cancer |
| topic | Ti3C2 Aptamer Targeted Chemo-photothermal therapy Cancer |
| url | http://www.sciencedirect.com/science/article/pii/S0264127523000710 |
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