Synthesis, bioactivity, and molecular docking of novel arylpiperazine derivatives as potential AR antagonists

Synthesis, bioactivity, and molecular docking of novel arylpiperazine derivatives as potential AR antagonists

Prostate cancer is one of the malignant tumors and the second most common malignant tumor in men. Clinically used androgen receptor (AR)–targeted drugs can antagonize androgen and inhibit tumor growth, but these drugs can cause serious resistance problems. To develop novel AR antagonists, 22 kinds o...

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Bibliographic Details
Main Authors: Yueheng Qi, Hong Chen, Shijin Chen, Jianliang Shen, Jingguo Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Chemistry
Subjects:
prostate cancer
synthesis
antagonistic activity
binding affinities
molecular docking
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.947065/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2022.947065/full

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