Clinical Relevance of Single-Voxel 1 H Mrs Metabolites in Discriminating Suprasellar Tumors
Introduction: Spatially resolved metabolic data obtained from Proton Magnetic Resonance Spectroscopy (1 H MRS) provides information which increases the diagnostic accuracy of imaging sequences in predicting the histology of suprasellar tumors. Aim: To evaluate the role of 1 H MRS in the diagno...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2016-07-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/8078/17988_CE[Ra]_F(P)_Reformat_PF2(PAG)_PFA(P).pdf |
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| author | A EINSTIEN RAHUL A VIRANI |
| author_facet | A EINSTIEN RAHUL A VIRANI |
| author_sort | A EINSTIEN |
| collection | DOAJ |
| description | Introduction: Spatially resolved metabolic data obtained from
Proton Magnetic Resonance Spectroscopy (1
H MRS) provides
information which increases the diagnostic accuracy of imaging
sequences in predicting the histology of suprasellar tumors.
Aim: To evaluate the role of 1
H MRS in the diagnosis of various
suprasellar tumors.
Materials and Methods: Sixty cases of various suprasellar,
hypothalamic and third ventricular neoplasms were investigated
with long-echo single voxel 1
H -MRS using 1.5 Tesla clinical
imager. Single-voxel spectroscopic examinations were guided
by T1-weighted or T2-weighted images. Statistical analysis was
carried out using IBM SPSS software version 19.
Results: We observed that whenever brain tissue was damaged
or replaced by any process, NAA was markedly reduced. Extraaxial lesions which do not infiltrate brain or contain neuroglial
tissue, didn’t demonstrate any NAA resonances. Cr was used
as an internal standard for semi-quantitative evaluation of
metabolic changes of other brain metabolites. Increased Cho
was seen in processes with elevated cell-membrane turnover.
Conclusion: Spectra obtained from different tumors exhibit
reproducible differences while histologically similar tumors yield
characteristic spectra with only minor differences. Pituitary
tumors were typically characterized by significant reduction of
NAA, Cr peak and moderate elevation of Cho peak. Gliomas
were typically characterized by decrease of NAA and Cr peaks
and increase of Cho peak. Craniopharyngiomas were typically
characterized by significant decrease of all metabolites. |
| first_indexed | 2024-12-13T07:16:00Z |
| format | Article |
| id | doaj.art-da686cbb72dd48ceb4df5bfe6c0dff36 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-13T07:16:00Z |
| publishDate | 2016-07-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-da686cbb72dd48ceb4df5bfe6c0dff362022-12-21T23:55:33ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-07-01107TC01TC0410.7860/JCDR/2016/17988.8078Clinical Relevance of Single-Voxel 1 H Mrs Metabolites in Discriminating Suprasellar TumorsA EINSTIEN0RAHUL A VIRANI1Assistant Professor, Department of Radiology, Chettinad Hospital & Research Institute, Kelambakkam, Tamil Nadu, India.Consultant, Department of Radiology, Horizon Imaging, Morbi, Rajkot, Gujarat, India.Introduction: Spatially resolved metabolic data obtained from Proton Magnetic Resonance Spectroscopy (1 H MRS) provides information which increases the diagnostic accuracy of imaging sequences in predicting the histology of suprasellar tumors. Aim: To evaluate the role of 1 H MRS in the diagnosis of various suprasellar tumors. Materials and Methods: Sixty cases of various suprasellar, hypothalamic and third ventricular neoplasms were investigated with long-echo single voxel 1 H -MRS using 1.5 Tesla clinical imager. Single-voxel spectroscopic examinations were guided by T1-weighted or T2-weighted images. Statistical analysis was carried out using IBM SPSS software version 19. Results: We observed that whenever brain tissue was damaged or replaced by any process, NAA was markedly reduced. Extraaxial lesions which do not infiltrate brain or contain neuroglial tissue, didn’t demonstrate any NAA resonances. Cr was used as an internal standard for semi-quantitative evaluation of metabolic changes of other brain metabolites. Increased Cho was seen in processes with elevated cell-membrane turnover. Conclusion: Spectra obtained from different tumors exhibit reproducible differences while histologically similar tumors yield characteristic spectra with only minor differences. Pituitary tumors were typically characterized by significant reduction of NAA, Cr peak and moderate elevation of Cho peak. Gliomas were typically characterized by decrease of NAA and Cr peaks and increase of Cho peak. Craniopharyngiomas were typically characterized by significant decrease of all metabolites.https://jcdr.net/articles/PDF/8078/17988_CE[Ra]_F(P)_Reformat_PF2(PAG)_PFA(P).pdfcholinecreatinen-acetylaspartatespectroscopy |
| spellingShingle | A EINSTIEN RAHUL A VIRANI Clinical Relevance of Single-Voxel 1 H Mrs Metabolites in Discriminating Suprasellar Tumors Journal of Clinical and Diagnostic Research choline creatine n-acetylaspartate spectroscopy |
| title | Clinical Relevance of Single-Voxel 1 H Mrs Metabolites in Discriminating Suprasellar Tumors |
| title_full | Clinical Relevance of Single-Voxel 1 H Mrs Metabolites in Discriminating Suprasellar Tumors |
| title_fullStr | Clinical Relevance of Single-Voxel 1 H Mrs Metabolites in Discriminating Suprasellar Tumors |
| title_full_unstemmed | Clinical Relevance of Single-Voxel 1 H Mrs Metabolites in Discriminating Suprasellar Tumors |
| title_short | Clinical Relevance of Single-Voxel 1 H Mrs Metabolites in Discriminating Suprasellar Tumors |
| title_sort | clinical relevance of single voxel 1 h mrs metabolites in discriminating suprasellar tumors |
| topic | choline creatine n-acetylaspartate spectroscopy |
| url | https://jcdr.net/articles/PDF/8078/17988_CE[Ra]_F(P)_Reformat_PF2(PAG)_PFA(P).pdf |
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