'Online' integration of sensory and fear memories in the rat medial temporal lobe
How does a stimulus never associated with danger become frightening? The present study addressed this question using a sensory preconditioning task with rats. In this task, rats integrate a sound-light memory formed in stage 1 with a light-danger memory formed in stage 2, as they show fear when test...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2019-06-01
|
| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/47085 |
| _version_ | 1818023982397390848 |
|---|---|
| author | Francesca S Wong R Fred Westbrook Nathan M Holmes |
| author_facet | Francesca S Wong R Fred Westbrook Nathan M Holmes |
| author_sort | Francesca S Wong |
| collection | DOAJ |
| description | How does a stimulus never associated with danger become frightening? The present study addressed this question using a sensory preconditioning task with rats. In this task, rats integrate a sound-light memory formed in stage 1 with a light-danger memory formed in stage 2, as they show fear when tested with the sound in stage 3. Here we show that this integration occurs ‘online’ during stage 2: when activity in the region that consolidated the sound-light memory (perirhinal cortex) was inhibited during formation of the light-danger memory, rats no longer showed fear when tested with the sound but continued to fear the light. Thus, fear that accrues to a stimulus paired with danger simultaneously spreads to its past associates, thereby roping those associates into a fear memory network. |
| first_indexed | 2024-12-10T03:52:58Z |
| format | Article |
| id | doaj.art-da68e64155044d8ab241715f6263af07 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-12-10T03:52:58Z |
| publishDate | 2019-06-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-da68e64155044d8ab241715f6263af072022-12-22T02:03:13ZengeLife Sciences Publications LtdeLife2050-084X2019-06-01810.7554/eLife.47085'Online' integration of sensory and fear memories in the rat medial temporal lobeFrancesca S Wong0https://orcid.org/0000-0002-8533-9833R Fred Westbrook1Nathan M Holmes2https://orcid.org/0000-0002-0592-2026School of Psychology, University of New South Wales, Sydney, AustraliaSchool of Psychology, University of New South Wales, Sydney, AustraliaSchool of Psychology, University of New South Wales, Sydney, AustraliaHow does a stimulus never associated with danger become frightening? The present study addressed this question using a sensory preconditioning task with rats. In this task, rats integrate a sound-light memory formed in stage 1 with a light-danger memory formed in stage 2, as they show fear when tested with the sound in stage 3. Here we show that this integration occurs ‘online’ during stage 2: when activity in the region that consolidated the sound-light memory (perirhinal cortex) was inhibited during formation of the light-danger memory, rats no longer showed fear when tested with the sound but continued to fear the light. Thus, fear that accrues to a stimulus paired with danger simultaneously spreads to its past associates, thereby roping those associates into a fear memory network.https://elifesciences.org/articles/47085memory integrationsensory preconditioningperirhinal cortex |
| spellingShingle | Francesca S Wong R Fred Westbrook Nathan M Holmes 'Online' integration of sensory and fear memories in the rat medial temporal lobe eLife memory integration sensory preconditioning perirhinal cortex |
| title | 'Online' integration of sensory and fear memories in the rat medial temporal lobe |
| title_full | 'Online' integration of sensory and fear memories in the rat medial temporal lobe |
| title_fullStr | 'Online' integration of sensory and fear memories in the rat medial temporal lobe |
| title_full_unstemmed | 'Online' integration of sensory and fear memories in the rat medial temporal lobe |
| title_short | 'Online' integration of sensory and fear memories in the rat medial temporal lobe |
| title_sort | online integration of sensory and fear memories in the rat medial temporal lobe |
| topic | memory integration sensory preconditioning perirhinal cortex |
| url | https://elifesciences.org/articles/47085 |
| work_keys_str_mv | AT francescaswong onlineintegrationofsensoryandfearmemoriesintheratmedialtemporallobe AT rfredwestbrook onlineintegrationofsensoryandfearmemoriesintheratmedialtemporallobe AT nathanmholmes onlineintegrationofsensoryandfearmemoriesintheratmedialtemporallobe |