Structural Conservation and Adaptation of the Bacterial Flagella Motor
Many bacteria require flagella for the ability to move, survive, and cause infection. The flagellum is a complex nanomachine that has evolved to increase the fitness of each bacterium to diverse environments. Over several decades, molecular, biochemical, and structural insights into the flagella hav...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/10/11/1492 |
| _version_ | 1797549481266249728 |
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| author | Brittany L. Carroll Jun Liu |
| author_facet | Brittany L. Carroll Jun Liu |
| author_sort | Brittany L. Carroll |
| collection | DOAJ |
| description | Many bacteria require flagella for the ability to move, survive, and cause infection. The flagellum is a complex nanomachine that has evolved to increase the fitness of each bacterium to diverse environments. Over several decades, molecular, biochemical, and structural insights into the flagella have led to a comprehensive understanding of the structure and function of this fascinating nanomachine. Notably, X-ray crystallography, cryo-electron microscopy (cryo-EM), and cryo-electron tomography (cryo-ET) have elucidated the flagella and their components to unprecedented resolution, gleaning insights into their structural conservation and adaptation. In this review, we focus on recent structural studies that have led to a mechanistic understanding of flagellar assembly, function, and evolution. |
| first_indexed | 2024-03-10T15:15:13Z |
| format | Article |
| id | doaj.art-da6901f659bc4e04aecaef6a7413545c |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T15:15:13Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-da6901f659bc4e04aecaef6a7413545c2023-11-20T19:01:48ZengMDPI AGBiomolecules2218-273X2020-10-011011149210.3390/biom10111492Structural Conservation and Adaptation of the Bacterial Flagella MotorBrittany L. Carroll0Jun Liu1Department of Microbial Pathogenesis, Yale School of Medicine, New Haven, CT 06536, USADepartment of Microbial Pathogenesis, Yale School of Medicine, New Haven, CT 06536, USAMany bacteria require flagella for the ability to move, survive, and cause infection. The flagellum is a complex nanomachine that has evolved to increase the fitness of each bacterium to diverse environments. Over several decades, molecular, biochemical, and structural insights into the flagella have led to a comprehensive understanding of the structure and function of this fascinating nanomachine. Notably, X-ray crystallography, cryo-electron microscopy (cryo-EM), and cryo-electron tomography (cryo-ET) have elucidated the flagella and their components to unprecedented resolution, gleaning insights into their structural conservation and adaptation. In this review, we focus on recent structural studies that have led to a mechanistic understanding of flagellar assembly, function, and evolution.https://www.mdpi.com/2218-273X/10/11/1492bacterial flagellumcryo-electron tomographycryo-electron microscopymolecular motorstructure and functiontorque generation |
| spellingShingle | Brittany L. Carroll Jun Liu Structural Conservation and Adaptation of the Bacterial Flagella Motor Biomolecules bacterial flagellum cryo-electron tomography cryo-electron microscopy molecular motor structure and function torque generation |
| title | Structural Conservation and Adaptation of the Bacterial Flagella Motor |
| title_full | Structural Conservation and Adaptation of the Bacterial Flagella Motor |
| title_fullStr | Structural Conservation and Adaptation of the Bacterial Flagella Motor |
| title_full_unstemmed | Structural Conservation and Adaptation of the Bacterial Flagella Motor |
| title_short | Structural Conservation and Adaptation of the Bacterial Flagella Motor |
| title_sort | structural conservation and adaptation of the bacterial flagella motor |
| topic | bacterial flagellum cryo-electron tomography cryo-electron microscopy molecular motor structure and function torque generation |
| url | https://www.mdpi.com/2218-273X/10/11/1492 |
| work_keys_str_mv | AT brittanylcarroll structuralconservationandadaptationofthebacterialflagellamotor AT junliu structuralconservationandadaptationofthebacterialflagellamotor |