Mesenchymal stem cell conditioned medium increases glial reactivity and decreases neuronal survival in spinal cord slice cultures

Mesenchymal stem cell conditioned medium increases glial reactivity and decreases neuronal survival in spinal cord slice cultures

Ex vivo spinal cord slice cultures (SCSC) allow study of spinal cord circuitry, maintaining stimuli responses comparable to live animals. Previously, we have shown that mesenchymal stem/stromal cell (MSC) transplantation in vivo reduced inflammation and increased nerve regeneration but MSC survival...

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Bibliographic Details
Main Authors: Chelsea R. Wood, Esri H. Juárez, Francesco Ferrini, Peter Myint, John Innes, Laura Lossi, Adalberto Merighi, William E.B. Johnson
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Biochemistry and Biophysics Reports
Subjects:
Mesenchymal stem/stromal cell
Spinal cord slice cultures
Astrocyte hypertrophy
Neuronal survival
Calcium imaging
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580821000704

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