Gut Microbiota Modulates the Efficiency of Programmed Cell Death Protein 1 Cancer Immunotherapies
Program cell death protein 1 (PD1) is considered as an inhibitory molecule that is expressed on the surface of activated T-cells and bound to PD-L1 and PD-L2 ligands. Several types of cancer cells express PD-L1 which can bind to PD1 on the surface of tumor-specific T-cells. PD1/PD-L1 ligation trigg...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2022-02-01
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| Series: | Iranian Journal of Allergy, Asthma and Immunology |
| Subjects: | |
| Online Access: | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/3003 |
| _version_ | 1819061314189787136 |
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| author | Azam Samei Mostafa Khedri |
| author_facet | Azam Samei Mostafa Khedri |
| author_sort | Azam Samei |
| collection | DOAJ |
| description |
Program cell death protein 1 (PD1) is considered as an inhibitory molecule that is expressed on the surface of activated T-cells and bound to PD-L1 and PD-L2 ligands. Several types of cancer cells express PD-L1 which can bind to PD1 on the surface of tumor-specific T-cells. PD1/PD-L1 ligation triggers a pathway to protect tumor cells from an effective response of tumor-specific T-cells. Different PD1/PD-L1 blocker antibodies are clinically used to promote the T-cell response against the cancer cells. Current studies suggest that the gut microbiome impacts the efficiency of PD1 blockade therapy in cancer patients. The association of several bacterial species with PD1 responder patients has been determined. The present study reviewed previous reports on the relation between the microbiome and immune checkpoint therapy (ICT). The results of studies were discussed considering adjuvant and molecular mimicry of microbial antigens by tumor-associated antigens and metabolic effects of microbial products on ICT.
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| first_indexed | 2024-12-21T14:40:55Z |
| format | Article |
| id | doaj.art-da6a831ea38141819f66785be6f8491b |
| institution | Directory Open Access Journal |
| issn | 1735-1502 1735-5249 |
| language | English |
| last_indexed | 2024-12-21T14:40:55Z |
| publishDate | 2022-02-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Allergy, Asthma and Immunology |
| spelling | doaj.art-da6a831ea38141819f66785be6f8491b2022-12-21T19:00:11ZengTehran University of Medical SciencesIranian Journal of Allergy, Asthma and Immunology1735-15021735-52492022-02-0121110.18502/ijaai.v21i1.8607Gut Microbiota Modulates the Efficiency of Programmed Cell Death Protein 1 Cancer ImmunotherapiesAzam Samei0Mostafa Khedri1Department of Clinical Laboratory Sciences, School of Allied Medical Sciences, Kashan University of Medical Sciences, Kashan, IranDepartment of Clinical Laboratory Sciences, School of Allied Medical Sciences, Kashan University of Medical Sciences, Kashan, Iran Program cell death protein 1 (PD1) is considered as an inhibitory molecule that is expressed on the surface of activated T-cells and bound to PD-L1 and PD-L2 ligands. Several types of cancer cells express PD-L1 which can bind to PD1 on the surface of tumor-specific T-cells. PD1/PD-L1 ligation triggers a pathway to protect tumor cells from an effective response of tumor-specific T-cells. Different PD1/PD-L1 blocker antibodies are clinically used to promote the T-cell response against the cancer cells. Current studies suggest that the gut microbiome impacts the efficiency of PD1 blockade therapy in cancer patients. The association of several bacterial species with PD1 responder patients has been determined. The present study reviewed previous reports on the relation between the microbiome and immune checkpoint therapy (ICT). The results of studies were discussed considering adjuvant and molecular mimicry of microbial antigens by tumor-associated antigens and metabolic effects of microbial products on ICT. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/3003Gastrointestinal microbiomeImmunotherapyNeoplasmsProgrammed cell death 1 receptor |
| spellingShingle | Azam Samei Mostafa Khedri Gut Microbiota Modulates the Efficiency of Programmed Cell Death Protein 1 Cancer Immunotherapies Iranian Journal of Allergy, Asthma and Immunology Gastrointestinal microbiome Immunotherapy Neoplasms Programmed cell death 1 receptor |
| title | Gut Microbiota Modulates the Efficiency of Programmed Cell Death Protein 1 Cancer Immunotherapies |
| title_full | Gut Microbiota Modulates the Efficiency of Programmed Cell Death Protein 1 Cancer Immunotherapies |
| title_fullStr | Gut Microbiota Modulates the Efficiency of Programmed Cell Death Protein 1 Cancer Immunotherapies |
| title_full_unstemmed | Gut Microbiota Modulates the Efficiency of Programmed Cell Death Protein 1 Cancer Immunotherapies |
| title_short | Gut Microbiota Modulates the Efficiency of Programmed Cell Death Protein 1 Cancer Immunotherapies |
| title_sort | gut microbiota modulates the efficiency of programmed cell death protein 1 cancer immunotherapies |
| topic | Gastrointestinal microbiome Immunotherapy Neoplasms Programmed cell death 1 receptor |
| url | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/3003 |
| work_keys_str_mv | AT azamsamei gutmicrobiotamodulatestheefficiencyofprogrammedcelldeathprotein1cancerimmunotherapies AT mostafakhedri gutmicrobiotamodulatestheefficiencyofprogrammedcelldeathprotein1cancerimmunotherapies |