Serum YKL-40 levels correlate with infarct volume, stroke severity, and functional outcome in acute ischemic stroke patients.
YKL-40 is associated with various neurological disorders. However, circulatory YKL-40 levels early after onset of acute ischemic stroke (AIS) have not been systematically assessed. We aimed to identify the temporal changes and clinical usefulness of measuring serum YKL-40 immediately following AIS.S...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3522716?pdf=render |
| _version_ | 1818542085767168000 |
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| author | Hyun Young Park Chang-Duk Jun Se-Jeong Jeon See-Sung Choi Hak-Ryul Kim Dan-Bee Choi Seongae Kwak Hak-Seung Lee Jin Sung Cheong Hong-Seob So Young-Jin Lee Do-Sim Park |
| author_facet | Hyun Young Park Chang-Duk Jun Se-Jeong Jeon See-Sung Choi Hak-Ryul Kim Dan-Bee Choi Seongae Kwak Hak-Seung Lee Jin Sung Cheong Hong-Seob So Young-Jin Lee Do-Sim Park |
| author_sort | Hyun Young Park |
| collection | DOAJ |
| description | YKL-40 is associated with various neurological disorders. However, circulatory YKL-40 levels early after onset of acute ischemic stroke (AIS) have not been systematically assessed. We aimed to identify the temporal changes and clinical usefulness of measuring serum YKL-40 immediately following AIS.Serum YKL-40 and C-reactive protein (CRP) levels were monitored over time in AIS patients (n = 105) and compared with those of stroke-free controls (n = 34). Infarct volume and stroke severity (National Institutes of Health Stroke Scale; NIHSS) were measured within 48 hours of symptom onset, and functional outcome (modified Rankin Scale; mRS) was measured 3 months after AIS.Within 12 hours of symptom onset, levels of YKL-40 (251 vs. 41 ng/mL) and CRP (1.50 vs. 0.96 µg/mL) were elevated in AIS patients compared to controls. The power of YKL-40 for discriminating AIS patients from controls was superior to that of CRP (area under the curve 0.84 vs. 0.64) and YKL-40 (r = 0.26, P<0.001) but not CRP levels were correlated with mRS. On day 2 of admission (D2), YKL-40 levels correlated with infarct volume and NIHSS. High YKL-40 levels predicted poor functional outcome (odds ratio 5.73, P = 0.03). YKL-40 levels peaked on D2 and declined on D3, whereas CRP levels were highest on D3.Our results demonstrate serial changes in serum YKL-40 levels immediately following AIS and provide the first evidence that it is a valid indicator of AIS extent and an early predictor of functional outcome. |
| first_indexed | 2024-12-11T22:17:32Z |
| format | Article |
| id | doaj.art-da6b8c5757e243e4afda6788139066f3 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T22:17:32Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-da6b8c5757e243e4afda6788139066f32022-12-22T00:48:33ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01712e5172210.1371/journal.pone.0051722Serum YKL-40 levels correlate with infarct volume, stroke severity, and functional outcome in acute ischemic stroke patients.Hyun Young ParkChang-Duk JunSe-Jeong JeonSee-Sung ChoiHak-Ryul KimDan-Bee ChoiSeongae KwakHak-Seung LeeJin Sung CheongHong-Seob SoYoung-Jin LeeDo-Sim ParkYKL-40 is associated with various neurological disorders. However, circulatory YKL-40 levels early after onset of acute ischemic stroke (AIS) have not been systematically assessed. We aimed to identify the temporal changes and clinical usefulness of measuring serum YKL-40 immediately following AIS.Serum YKL-40 and C-reactive protein (CRP) levels were monitored over time in AIS patients (n = 105) and compared with those of stroke-free controls (n = 34). Infarct volume and stroke severity (National Institutes of Health Stroke Scale; NIHSS) were measured within 48 hours of symptom onset, and functional outcome (modified Rankin Scale; mRS) was measured 3 months after AIS.Within 12 hours of symptom onset, levels of YKL-40 (251 vs. 41 ng/mL) and CRP (1.50 vs. 0.96 µg/mL) were elevated in AIS patients compared to controls. The power of YKL-40 for discriminating AIS patients from controls was superior to that of CRP (area under the curve 0.84 vs. 0.64) and YKL-40 (r = 0.26, P<0.001) but not CRP levels were correlated with mRS. On day 2 of admission (D2), YKL-40 levels correlated with infarct volume and NIHSS. High YKL-40 levels predicted poor functional outcome (odds ratio 5.73, P = 0.03). YKL-40 levels peaked on D2 and declined on D3, whereas CRP levels were highest on D3.Our results demonstrate serial changes in serum YKL-40 levels immediately following AIS and provide the first evidence that it is a valid indicator of AIS extent and an early predictor of functional outcome.http://europepmc.org/articles/PMC3522716?pdf=render |
| spellingShingle | Hyun Young Park Chang-Duk Jun Se-Jeong Jeon See-Sung Choi Hak-Ryul Kim Dan-Bee Choi Seongae Kwak Hak-Seung Lee Jin Sung Cheong Hong-Seob So Young-Jin Lee Do-Sim Park Serum YKL-40 levels correlate with infarct volume, stroke severity, and functional outcome in acute ischemic stroke patients. PLoS ONE |
| title | Serum YKL-40 levels correlate with infarct volume, stroke severity, and functional outcome in acute ischemic stroke patients. |
| title_full | Serum YKL-40 levels correlate with infarct volume, stroke severity, and functional outcome in acute ischemic stroke patients. |
| title_fullStr | Serum YKL-40 levels correlate with infarct volume, stroke severity, and functional outcome in acute ischemic stroke patients. |
| title_full_unstemmed | Serum YKL-40 levels correlate with infarct volume, stroke severity, and functional outcome in acute ischemic stroke patients. |
| title_short | Serum YKL-40 levels correlate with infarct volume, stroke severity, and functional outcome in acute ischemic stroke patients. |
| title_sort | serum ykl 40 levels correlate with infarct volume stroke severity and functional outcome in acute ischemic stroke patients |
| url | http://europepmc.org/articles/PMC3522716?pdf=render |
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