The Nucleotide Capture Region of Alpha Hemolysin: Insights into Nanopore Design for DNA Sequencing from Molecular Dynamics Simulations

The Nucleotide Capture Region of Alpha Hemolysin: Insights into Nanopore Design for DNA Sequencing from Molecular Dynamics Simulations

Nanopore technology for DNA sequencing is constantly being refined and improved. In strand sequencing a single strand of DNA is fed through a nanopore and subsequent fluctuations in the current are measured. A major hurdle is that the DNA is translocated through the pore at a rate that is too fast f...

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Bibliographic Details
Main Authors: Richard M. A. Manara, Susana Tomasio, Syma Khalid
Format: Article
Language:English
Published: MDPI AG 2015-01-01
Series:Nanomaterials
Subjects:
alpha-hemolysin
exonuclease sequencing
molecular dynamics
nanopore sequencing
Online Access:http://www.mdpi.com/2079-4991/5/1/144

Internet

http://www.mdpi.com/2079-4991/5/1/144

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