Microglial APOE4: more is less and less is more

Abstract Apolipoprotein E (APOE) is the single greatest genetic risk factor for late onset Alzheimer’s disease (AD). Yet, the cell-specific effects of APOE on microglia function have remained unclear. Fortunately, two comprehensive new studies published in the latest issue of Nature Immunology have...

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Bibliographic Details
Main Authors: Ghazaleh Eskandari-Sedighi, Mathew Blurton-Jones
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Molecular Neurodegeneration
Subjects:
Online Access:https://doi.org/10.1186/s13024-023-00693-6