TEN-YEAR OUTCOMES AFTER BREAST-CONSERVING SURGERY WITH INTRAOPERATIVE RADIOTHERAPY FOR BREAST CANCER
The purpose of the study was to analyze the 10-year outcomes after breast-conserving surgery with electronbeam intraoperative radiation therapy (IORT) followed by external beam radiotherapy (EBRT) in patients with breast cancer. Material and methods. The study included 905 patients with stage T1–2N0...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Russian Academy of Sciences, Tomsk National Research Medical Center
2017-12-01
|
| Series: | Сибирский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.siboncoj.ru/jour/article/view/636 |
| _version_ | 1797875894745825280 |
|---|---|
| author | A. V. Doroshenko E. M. Slonimskaya Zh. A. Startseva V. A. Lisin Ye. Yu. Garbukov N. A. Tarabanovskaya Yu. L. Kokorina N. V. Litviakov |
| author_facet | A. V. Doroshenko E. M. Slonimskaya Zh. A. Startseva V. A. Lisin Ye. Yu. Garbukov N. A. Tarabanovskaya Yu. L. Kokorina N. V. Litviakov |
| author_sort | A. V. Doroshenko |
| collection | DOAJ |
| description | The purpose of the study was to analyze the 10-year outcomes after breast-conserving surgery with electronbeam intraoperative radiation therapy (IORT) followed by external beam radiotherapy (EBRT) in patients with breast cancer. Material and methods. The study included 905 patients with stage T1–2N0–1M0 breast cancer, who underwent breast-conserving surgery. Group I consisted of 746 patients who received IORT at a single dose of 10 Gy, biologically equivalent to 24.8 in standard fractionation, followed by EBRT at a total dose of 46 ± 8.1 Gy. A combined IORT and EBRT photon-equivalent dose delivered to the tumor bed was 60 Gy. Group II (control group) comprised 159 who received EBRT at a total dose of 40–44 Gy delivered to the remaining breast tissue and electron therapy delivered to the area of postoperative scar (a single 3–4 Gy fraction, 3 days per week, to the total photon-equivalent dose of 15-18 Gy). The combined photon-equivalent dose was 58 Gy. Results. According to RTOG/EORTC toxicity criteria, grade 1 radiation-induced damage was observed in 413 (55.3 %) patients of Group I and in 71 (44.6 %) patients of Group II (р=0.2); grade 2 radiation-induced damage in 76 (10.1%) and 43 (27 %) patients (p=0.0002) and grade 3 in 18 (2.4 %) and 9 (5.7 %) patients, respectively (р=0.1). Late radiation-induced injuries (grade I and 2) were mostly observed in the control group. Local recurrence was diagnosed in 11 (1.47 %) patients of Group I and in 14 (8.8 %) patients of Group II. The 10-year disease-free survival rates were 97.3 ± 1.08 % and 88.96 ± 2.8 % in Group I and Group II patients, respectively (р<0.05). The metastasis-free survival rates were 94.4 ± 2.7 and 90.46 ± 1.4 %, respectively (р><0.05). Conclusion. In patients with stage T1–2N0–1M0 breast cancer, combination of IORT and EBRT resulted in higher recurrence-free and metastasis-free survival rates than EBRT alone. Key words: breast cancer, combined modality treatment, intraoperative radiation therapy, breast-conserving surgery.><0.05). The metastasis-free survival rates were 94.4 ± 2.7 and 90.46 ± 1.4 %, respectively (р<0.05). Conclusion. In patients with stage T1–2N0–1M0 breast cancer, combination of IORT and EBRT resulted in higher recurrence-free and metastasis-free survival rates than EBRT alone. |
| first_indexed | 2024-04-10T01:53:43Z |
| format | Article |
| id | doaj.art-da6f1316fab4447ba708b19bcc927171 |
| institution | Directory Open Access Journal |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| last_indexed | 2024-04-10T01:53:43Z |
| publishDate | 2017-12-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj.art-da6f1316fab4447ba708b19bcc9271712023-03-13T09:05:50ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682017-12-01166111710.21294/1814-4861-2017-16-6-11-17493TEN-YEAR OUTCOMES AFTER BREAST-CONSERVING SURGERY WITH INTRAOPERATIVE RADIOTHERAPY FOR BREAST CANCERA. V. Doroshenko0E. M. Slonimskaya1Zh. A. Startseva2V. A. Lisin3Ye. Yu. Garbukov4N. A. Tarabanovskaya5Yu. L. Kokorina6N. V. Litviakov7Научно-исследовательский институт онкологии, Томский национальный исследовательский медицинский центр Российской академии наук, г. ТомскНаучно-исследовательский институт онкологии, Томский национальный исследовательский медицинский центр Российской академии наук, г. Томск; ФГБОУ ВО «Сибирский государственный медицинский университет» Минздрава России, г. ТомскНаучно-исследовательский институт онкологии, Томский национальный исследовательский медицинский центр Российской академии наук, г. ТомскНаучно-исследовательский институт онкологии, Томский национальный исследовательский медицинский центр Российской академии наук, г. ТомскНаучно-исследовательский институт онкологии, Томский национальный исследовательский медицинский центр Российской академии наук, г. ТомскНаучно-исследовательский институт онкологии, Томский национальный исследовательский медицинский центр Российской академии наук, г. ТомскНаучно-исследовательский институт онкологии, Томский национальный исследовательский медицинский центр Российской академии наук, г. ТомскНаучно-исследовательский институт онкологии, Томский национальный исследовательский медицинский центр Российской академии наук, г. ТомскThe purpose of the study was to analyze the 10-year outcomes after breast-conserving surgery with electronbeam intraoperative radiation therapy (IORT) followed by external beam radiotherapy (EBRT) in patients with breast cancer. Material and methods. The study included 905 patients with stage T1–2N0–1M0 breast cancer, who underwent breast-conserving surgery. Group I consisted of 746 patients who received IORT at a single dose of 10 Gy, biologically equivalent to 24.8 in standard fractionation, followed by EBRT at a total dose of 46 ± 8.1 Gy. A combined IORT and EBRT photon-equivalent dose delivered to the tumor bed was 60 Gy. Group II (control group) comprised 159 who received EBRT at a total dose of 40–44 Gy delivered to the remaining breast tissue and electron therapy delivered to the area of postoperative scar (a single 3–4 Gy fraction, 3 days per week, to the total photon-equivalent dose of 15-18 Gy). The combined photon-equivalent dose was 58 Gy. Results. According to RTOG/EORTC toxicity criteria, grade 1 radiation-induced damage was observed in 413 (55.3 %) patients of Group I and in 71 (44.6 %) patients of Group II (р=0.2); grade 2 radiation-induced damage in 76 (10.1%) and 43 (27 %) patients (p=0.0002) and grade 3 in 18 (2.4 %) and 9 (5.7 %) patients, respectively (р=0.1). Late radiation-induced injuries (grade I and 2) were mostly observed in the control group. Local recurrence was diagnosed in 11 (1.47 %) patients of Group I and in 14 (8.8 %) patients of Group II. The 10-year disease-free survival rates were 97.3 ± 1.08 % and 88.96 ± 2.8 % in Group I and Group II patients, respectively (р<0.05). The metastasis-free survival rates were 94.4 ± 2.7 and 90.46 ± 1.4 %, respectively (р><0.05). Conclusion. In patients with stage T1–2N0–1M0 breast cancer, combination of IORT and EBRT resulted in higher recurrence-free and metastasis-free survival rates than EBRT alone. Key words: breast cancer, combined modality treatment, intraoperative radiation therapy, breast-conserving surgery.><0.05). The metastasis-free survival rates were 94.4 ± 2.7 and 90.46 ± 1.4 %, respectively (р<0.05). Conclusion. In patients with stage T1–2N0–1M0 breast cancer, combination of IORT and EBRT resulted in higher recurrence-free and metastasis-free survival rates than EBRT alone.https://www.siboncoj.ru/jour/article/view/636рак молочной железыкомбинированное лечениеинтраоперационная лучевая терапияорганосохраняющие операции |
| spellingShingle | A. V. Doroshenko E. M. Slonimskaya Zh. A. Startseva V. A. Lisin Ye. Yu. Garbukov N. A. Tarabanovskaya Yu. L. Kokorina N. V. Litviakov TEN-YEAR OUTCOMES AFTER BREAST-CONSERVING SURGERY WITH INTRAOPERATIVE RADIOTHERAPY FOR BREAST CANCER Сибирский онкологический журнал рак молочной железы комбинированное лечение интраоперационная лучевая терапия органосохраняющие операции |
| title | TEN-YEAR OUTCOMES AFTER BREAST-CONSERVING SURGERY WITH INTRAOPERATIVE RADIOTHERAPY FOR BREAST CANCER |
| title_full | TEN-YEAR OUTCOMES AFTER BREAST-CONSERVING SURGERY WITH INTRAOPERATIVE RADIOTHERAPY FOR BREAST CANCER |
| title_fullStr | TEN-YEAR OUTCOMES AFTER BREAST-CONSERVING SURGERY WITH INTRAOPERATIVE RADIOTHERAPY FOR BREAST CANCER |
| title_full_unstemmed | TEN-YEAR OUTCOMES AFTER BREAST-CONSERVING SURGERY WITH INTRAOPERATIVE RADIOTHERAPY FOR BREAST CANCER |
| title_short | TEN-YEAR OUTCOMES AFTER BREAST-CONSERVING SURGERY WITH INTRAOPERATIVE RADIOTHERAPY FOR BREAST CANCER |
| title_sort | ten year outcomes after breast conserving surgery with intraoperative radiotherapy for breast cancer |
| topic | рак молочной железы комбинированное лечение интраоперационная лучевая терапия органосохраняющие операции |
| url | https://www.siboncoj.ru/jour/article/view/636 |
| work_keys_str_mv | AT avdoroshenko tenyearoutcomesafterbreastconservingsurgerywithintraoperativeradiotherapyforbreastcancer AT emslonimskaya tenyearoutcomesafterbreastconservingsurgerywithintraoperativeradiotherapyforbreastcancer AT zhastartseva tenyearoutcomesafterbreastconservingsurgerywithintraoperativeradiotherapyforbreastcancer AT valisin tenyearoutcomesafterbreastconservingsurgerywithintraoperativeradiotherapyforbreastcancer AT yeyugarbukov tenyearoutcomesafterbreastconservingsurgerywithintraoperativeradiotherapyforbreastcancer AT natarabanovskaya tenyearoutcomesafterbreastconservingsurgerywithintraoperativeradiotherapyforbreastcancer AT yulkokorina tenyearoutcomesafterbreastconservingsurgerywithintraoperativeradiotherapyforbreastcancer AT nvlitviakov tenyearoutcomesafterbreastconservingsurgerywithintraoperativeradiotherapyforbreastcancer |