The Development of Tungsten Biochemistry—A Personal Recollection
The development of tungsten biochemistry is sketched from the viewpoint of personal participation. Following its identification as a bio-element, a catalogue of genes, enzymes, and reactions was built up. EPR spectroscopic monitoring of redox states was, and remains, a prominent tool in attempts to...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/10/4017 |
| _version_ | 1797598948036182016 |
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| author | Wilfred R. Hagen |
| author_facet | Wilfred R. Hagen |
| author_sort | Wilfred R. Hagen |
| collection | DOAJ |
| description | The development of tungsten biochemistry is sketched from the viewpoint of personal participation. Following its identification as a bio-element, a catalogue of genes, enzymes, and reactions was built up. EPR spectroscopic monitoring of redox states was, and remains, a prominent tool in attempts to understand tungstopterin-based catalysis. A paucity of pre-steady-state data remains a hindrance to overcome to this day. Tungstate transport systems have been characterized and found to be very specific for W over Mo. Additional selectivity is presented by the biosynthetic machinery for tungstopterin enzymes. Metallomics analysis of hyperthermophilic archaeon <i>Pyrococcus furiosus</i> indicates a comprehensive inventory of tungsten proteins. |
| first_indexed | 2024-03-11T03:27:48Z |
| format | Article |
| id | doaj.art-da6f85e4140c4744ae07d464829cc03a |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T03:27:48Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-da6f85e4140c4744ae07d464829cc03a2023-11-18T02:38:05ZengMDPI AGMolecules1420-30492023-05-012810401710.3390/molecules28104017The Development of Tungsten Biochemistry—A Personal RecollectionWilfred R. Hagen0Department of Biotechnology, Delft University of Technology, Building 58, Van der Maasweg 9, 2629 HZ Delft, The NetherlandsThe development of tungsten biochemistry is sketched from the viewpoint of personal participation. Following its identification as a bio-element, a catalogue of genes, enzymes, and reactions was built up. EPR spectroscopic monitoring of redox states was, and remains, a prominent tool in attempts to understand tungstopterin-based catalysis. A paucity of pre-steady-state data remains a hindrance to overcome to this day. Tungstate transport systems have been characterized and found to be very specific for W over Mo. Additional selectivity is presented by the biosynthetic machinery for tungstopterin enzymes. Metallomics analysis of hyperthermophilic archaeon <i>Pyrococcus furiosus</i> indicates a comprehensive inventory of tungsten proteins.https://www.mdpi.com/1420-3049/28/10/4017tungstentungstoenzymeEPRtungstopterin<i>Pyrococcus furiosus</i>transport |
| spellingShingle | Wilfred R. Hagen The Development of Tungsten Biochemistry—A Personal Recollection Molecules tungsten tungstoenzyme EPR tungstopterin <i>Pyrococcus furiosus</i> transport |
| title | The Development of Tungsten Biochemistry—A Personal Recollection |
| title_full | The Development of Tungsten Biochemistry—A Personal Recollection |
| title_fullStr | The Development of Tungsten Biochemistry—A Personal Recollection |
| title_full_unstemmed | The Development of Tungsten Biochemistry—A Personal Recollection |
| title_short | The Development of Tungsten Biochemistry—A Personal Recollection |
| title_sort | development of tungsten biochemistry a personal recollection |
| topic | tungsten tungstoenzyme EPR tungstopterin <i>Pyrococcus furiosus</i> transport |
| url | https://www.mdpi.com/1420-3049/28/10/4017 |
| work_keys_str_mv | AT wilfredrhagen thedevelopmentoftungstenbiochemistryapersonalrecollection AT wilfredrhagen developmentoftungstenbiochemistryapersonalrecollection |