Antibacterial Effect Leaf Extract of Avicennia marina on Standard and Clinical Strains of Acinetobacter baumannii
Background: Acinetobacter baumannii is an opportunistic pathogen and a nosocomial infection agent. Antibiotic resistance in this organism results in serious health problem such as treatment failure and increased mortality. Mangrove plants, especially Avicennia marina, are a potential bioresource for...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Bushehr University of Medical Sciences
2019-08-01
|
| Series: | Iranian South Medical Journal |
| Subjects: | |
| Online Access: | http://ismj.bpums.ac.ir/article-1-1094-en.html |
| _version_ | 1818421428314177536 |
|---|---|
| author | Mehdi Mahmudpour Azam Askari Forogh Yousefi |
| author_facet | Mehdi Mahmudpour Azam Askari Forogh Yousefi |
| author_sort | Mehdi Mahmudpour |
| collection | DOAJ |
| description | Background: Acinetobacter baumannii is an opportunistic pathogen and a nosocomial infection agent. Antibiotic resistance in this organism results in serious health problem such as treatment failure and
increased mortality. Mangrove plants, especially Avicennia marina, are a potential bioresource for new drugs as they have been used in traditional medicine. This study aimed to investigate antibacterial effects of A.marina leaf extract on standard and clinical stains of A.baumannii in vitro.
Materials and Methods: A.marina leaves were dried in outdoor shade and ground. Then glycerin extract was provided at a concentration of 200 µg/ml and its antibacterial properties were assessed on standard strain and carbapenem-resistant clinical isolates of A.baumannii using agar well diffusion method. Minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) were determined.
Results: A. marina leaf extract had a significant antibacterial effect on all 6 strains at a concentration of 100 µL in agar well diffusion method. MICs were 25µg/ml in all strains. MBCs were 12.5µg/ml in standard strains. The most resistant strain against the extract was cefepime-resistant clinical strain.
Conclusion: A. marina leaf crude extract had significant antibacterial effects on standard and
carbapenem-resistant clinical isolates of A. baumannii. |
| first_indexed | 2024-12-14T13:10:12Z |
| format | Article |
| id | doaj.art-da6fc7d9dae84a8a92cb890506081da0 |
| institution | Directory Open Access Journal |
| issn | 1735-4374 1735-6954 |
| language | English |
| last_indexed | 2024-12-14T13:10:12Z |
| publishDate | 2019-08-01 |
| publisher | Bushehr University of Medical Sciences |
| record_format | Article |
| series | Iranian South Medical Journal |
| spelling | doaj.art-da6fc7d9dae84a8a92cb890506081da02022-12-21T23:00:13ZengBushehr University of Medical SciencesIranian South Medical Journal1735-43741735-69542019-08-01223150159Antibacterial Effect Leaf Extract of Avicennia marina on Standard and Clinical Strains of Acinetobacter baumanniiMehdi Mahmudpour0Azam Askari1Forogh Yousefi2 The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran Department of Microbiology and Parasitology, School of Medicine,Bushehr University of Medical Sciences, Bushehr, Iran Department of Microbiology and Parasitology, School of Medicine,Bushehr University of Medical Sciences, Bushehr, Iran Background: Acinetobacter baumannii is an opportunistic pathogen and a nosocomial infection agent. Antibiotic resistance in this organism results in serious health problem such as treatment failure and increased mortality. Mangrove plants, especially Avicennia marina, are a potential bioresource for new drugs as they have been used in traditional medicine. This study aimed to investigate antibacterial effects of A.marina leaf extract on standard and clinical stains of A.baumannii in vitro. Materials and Methods: A.marina leaves were dried in outdoor shade and ground. Then glycerin extract was provided at a concentration of 200 µg/ml and its antibacterial properties were assessed on standard strain and carbapenem-resistant clinical isolates of A.baumannii using agar well diffusion method. Minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) were determined. Results: A. marina leaf extract had a significant antibacterial effect on all 6 strains at a concentration of 100 µL in agar well diffusion method. MICs were 25µg/ml in all strains. MBCs were 12.5µg/ml in standard strains. The most resistant strain against the extract was cefepime-resistant clinical strain. Conclusion: A. marina leaf crude extract had significant antibacterial effects on standard and carbapenem-resistant clinical isolates of A. baumannii.http://ismj.bpums.ac.ir/article-1-1094-en.htmlAvicannia marinaAcinetobacter baumanniiantibacterial effectMICMBC. |
| spellingShingle | Mehdi Mahmudpour Azam Askari Forogh Yousefi Antibacterial Effect Leaf Extract of Avicennia marina on Standard and Clinical Strains of Acinetobacter baumannii Iranian South Medical Journal Avicannia marina Acinetobacter baumannii antibacterial effect MIC MBC. |
| title | Antibacterial Effect Leaf Extract of Avicennia marina on Standard and Clinical Strains of Acinetobacter baumannii |
| title_full | Antibacterial Effect Leaf Extract of Avicennia marina on Standard and Clinical Strains of Acinetobacter baumannii |
| title_fullStr | Antibacterial Effect Leaf Extract of Avicennia marina on Standard and Clinical Strains of Acinetobacter baumannii |
| title_full_unstemmed | Antibacterial Effect Leaf Extract of Avicennia marina on Standard and Clinical Strains of Acinetobacter baumannii |
| title_short | Antibacterial Effect Leaf Extract of Avicennia marina on Standard and Clinical Strains of Acinetobacter baumannii |
| title_sort | antibacterial effect leaf extract of avicennia marina on standard and clinical strains of acinetobacter baumannii |
| topic | Avicannia marina Acinetobacter baumannii antibacterial effect MIC MBC. |
| url | http://ismj.bpums.ac.ir/article-1-1094-en.html |
| work_keys_str_mv | AT mehdimahmudpour antibacterialeffectleafextractofavicenniamarinaonstandardandclinicalstrainsofacinetobacterbaumannii AT azamaskari antibacterialeffectleafextractofavicenniamarinaonstandardandclinicalstrainsofacinetobacterbaumannii AT foroghyousefi antibacterialeffectleafextractofavicenniamarinaonstandardandclinicalstrainsofacinetobacterbaumannii |