DHA Affects Microtubule Dynamics Through Reduction of Phospho-TCTP Levels and Enhances the Antiproliferative Effect of T-DM1 in Trastuzumab-Resistant HER2-Positive Breast Cancer Cell Lines

DHA Affects Microtubule Dynamics Through Reduction of Phospho-TCTP Levels and Enhances the Antiproliferative Effect of T-DM1 in Trastuzumab-Resistant HER2-Positive Breast Cancer Cell Lines

Trastuzumab emtansine (T-DM1) is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugated to the microtubule-targeting agent emtansine (DM1). T-DM1 is an effective agent in the treatment of patients with HER2-positive breast cancer whose disease has progressed on the first-li...

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Bibliographic Details
Main Authors: Silvia D’Amico, Ewa Krystyna Krasnowska, Isabella Manni, Gabriele Toietta, Silvia Baldari, Giulia Piaggio, Marco Ranalli, Alessandra Gambacurta, Claudio Vernieri, Flavio Di Giacinto, Francesca Bernassola, Filippo de Braud, Maria Lucibello
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cells
Subjects:
phospho-TCTP
DHA
T-DM1
HER2-positive breast cancer
Online Access:https://www.mdpi.com/2073-4409/9/5/1260

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